Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael J Pulkoski-Gross"'
Autor:
Yong Tang, Thomas R Meister, Marta Walczak, Michael J Pulkoski-Gross, Sanjay B Hari, Robert T Sauer, Katherine Amberg-Johnson, Ellen Yeh
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000136 (2019)
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid-the apicoplast-which originated from a secondary (eukaryote-eukaryote) endosymbiosis. To
Externí odkaz:
https://doaj.org/article/e2ce2829b65d4485919a520958080bb4
Autor:
Michael J. Pulkoski-Gross, Meredith L. Jenkins, Jean-Philip Truman, Mohamed F. Salama, Christopher J. Clarke, John E. Burke, Yusuf A. Hannun, Lina M. Obeid
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 462-474 (2018)
Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation. To produce S1P, SK1 must access sphingosine di
Externí odkaz:
https://doaj.org/article/6c41b3add6ef4dec98d3fe3e1e0e39de
Publikováno v:
Toxicon. 214:S47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568b021229f03f82c31a6e064481ec44
https://doi.org/10.1016/j.toxicon.2021.11.101
https://doi.org/10.1016/j.toxicon.2021.11.101
Autor:
Mark Smith, Atsuko Ochida, Stephanie Kabeche, Thamina Akther, Takashi Ichikawa, Michael J. Pulkoski-Gross, Jumpei Aida, Paul S. Humphries, Ellen Yeh
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
A series of novel thiazole-containing amides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f589b25651e73127628ffa91a54ecc8
https://pubmed.ncbi.nlm.nih.gov/33766764
https://pubmed.ncbi.nlm.nih.gov/33766764
Publikováno v:
mBio
mBio, Vol 11, Iss 5 (2020)
mBio, Vol 11, Iss 5 (2020)
Plasmodium parasites, which cause malaria, and related apicomplexans are important human and veterinary pathogens. These parasites represent a highly divergent and understudied branch of eukaryotes, and as such often defy the expectations set by mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585857895b6d14459fe51c1deaabfcdf
https://doi.org/10.1128/mbio.01492-20
https://doi.org/10.1128/mbio.01492-20
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis
Autor:
Michael J. Pulkoski-Gross, Agnieszka B. Bialkowska, Joachim D. Uys, Ashley J. Snider, Zdzislaw M. Szulc, Yusuf A. Hannun, Danyelle M. Townsend, Aiping Bai, Nicolas Coant, Alicja Bielawska, K. Alexa Orr-Gandy, Lina M. Obeid
Publikováno v:
Prostaglandins & Other Lipid Mediators. 130:47-56
Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid metabolite which has been implicated in many diseases including cancer and inflammatory diseases. Recently, sphingosine kinase 1 (SK1), one of the isozymes which generates S1P, has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559968c84508e8cefd6e305d91fe6891
https://doi.org/10.1016/j.prostaglandins.2017.03.006
https://doi.org/10.1016/j.prostaglandins.2017.03.006
Autor:
Katherine Amberg-Johnson, Ellen Yeh, Thomas R. Meister, Robert T. Sauer, Michael J. Pulkoski-Gross, Yong Tang, Sanjay B. Hari, Marta Walczak
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000136 (2019)
PLoS Biology
PLoS Biology
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid—the apicoplast—which originated from a secondary (eukaryote–eukaryote) endosymbiosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cefbb7e2fbc91df904aa37798ef7eb
https://doaj.org/article/e2ce2829b65d4485919a520958080bb4
https://doaj.org/article/e2ce2829b65d4485919a520958080bb4
Publikováno v:
Oncotarget
// Brittany L. Carroll 1 , Michael J. Pulkoski-Gross 1, 2 , Yusuf A. Hannun 1 , Lina M. Obeid 1, 3 1 Stony Brook Cancer Center and The Department of Medicine, Stony Brook, New York, USA 2 Pharmacological Sciences, Stony Brook University, Health Scien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942329d0e6fe6436c983c0b0fd5b7191
https://doi.org/10.18632/oncotarget.7566
https://doi.org/10.18632/oncotarget.7566
Autor:
Lina M. Obeid, Yusuf A. Hannun, Michael J. Pulkoski-Gross, Brittany Carroll, Mohamed Salama, Mohamad Adada
Publikováno v:
The FASEB Journal. 29:2803-2813
Sphingosine kinase 1 (SK1), the enzyme responsible for sphingosine 1-phosphate (S1P) production, is overexpressed in many human solid tumors. However, its role in clear cell renal cell carcinoma (ccRCC) has not been described previously. ccRCC cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35024e758cb413d0ed7a048fba7dca70
https://doi.org/10.1096/fj.15-270413
https://doi.org/10.1096/fj.15-270413
Autor:
George Georghiou, Michael J. Pulkoski-Gross, David R. Liu, Markus A. Seeliger, Ralph E. Kleiner
Publikováno v:
Nature chemical biology
Protein kinases are attractive therapeutic targets, but their high sequence and structural conservation complicates the development of specific inhibitors. We recently discovered from a DNA-templated macrocycle library inhibitors with unusually high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb0ee824ba64c5248584d985bec5927
http://europepmc.org/articles/PMC3307835
http://europepmc.org/articles/PMC3307835