Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Michael J Palmer"'
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279412 (2022)
Legacy arsenic (As) contamination from past mining operations remains an environmental concern in lakes of the Yellowknife area (Northwest Territories, Canada) due to its post-depositional mobility in sediment and potential for continued remobilizati
Externí odkaz:
https://doaj.org/article/7942105f2bc0424a8f1299cbc357462a
Autor:
Yaqing Jiao, Sarah Preston, Anson V. Koehler, Andreas J. Stroehlein, Bill C. H. Chang, Kaylene J. Simpson, Karla J. Cowley, Michael J. Palmer, Benoît Laleu, Timothy N. C. Wells, Abdul Jabbar, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Background In partnership with the Medicines for Malaria Venture (MMV), we screened a collection (‘Stasis Box’) of 400 compounds (which have been in clinical development but have not been approved for illnesses other than neglected infec
Externí odkaz:
https://doaj.org/article/42151eb5042e4f648e96208755c17b05
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Autor:
Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V. Koehler, Gillian M. Fisher, Katherine T. Andrews, Benoît Laleu, Michael J. Palmer, Jeremy N. Burrows, Timothy N. C. Wells, Qingmin Wang, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Background In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber’s pole worm), one of the most pathogenic parasites of ruminants
Externí odkaz:
https://doaj.org/article/23c9a23e634d4f5fa18d8f7b336a309d
Autor:
John Chételat, Michael J. Palmer, Katrina Paudyn, Heather Jamieson, Marc Amyot, Reed Harris, Raymond Hesslein, Nicolas Pelletier, Ines Peraza
Publikováno v:
Journal of Hazardous Materials. 452:131230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d8b675f1a6b4320f6ea8ebcb531916
https://doi.org/10.1016/j.jhazmat.2023.131230
https://doi.org/10.1016/j.jhazmat.2023.131230
Publikováno v:
Cold Regions Science and Technology. 210:103808
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d7d81787cd993dfac526b78fcfc6a5
https://doi.org/10.1016/j.coldregions.2023.103808
https://doi.org/10.1016/j.coldregions.2023.103808
Publikováno v:
Cancer Medicine, Vol 10, Iss 9, Pp 3026-3034 (2021)
Cancer Medicine
Cancer Medicine
Background Missing patient reported outcomes data threaten the validity of PRO‐specific findings and conclusions from randomized controlled trials by introducing bias due to data missing not at random. Clinical Research Associates are a largely une
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdb437f1bdd0cd75ef52b11ab0ccc8b
https://doaj.org/article/d4160077a1d44c25803a36ab731ff5b4
https://doaj.org/article/d4160077a1d44c25803a36ab731ff5b4
Autor:
Sergio Wittlin, Sachel Mok, Benoît Laleu, Anwu Zhou, Susan A. Charman, Margaret A. Phillips, Tomas Yeo, David A. Fidock, Alisje Churchyard, Joseph M. Ready, Francisco-Javier Gamo, Ioanna Deni, John Okombo, Bruce A. Posner, Aloysus K. Lawong, Jessica L. Bridgford, Elizabeth A. Winzeler, Benigno Crespo, Michael J. Palmer, Hanspeter Niederstrasser, Josefine Striepen, Suraksha Gahalawat, Jake Baum, Nimisha Mittal
Publikováno v:
Journal of Medicinal Chemistry. 64:2739-2761
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2c4959d61f50243834064afd89e585
https://doi.org/10.1021/acs.jmedchem.0c02022
https://doi.org/10.1021/acs.jmedchem.0c02022
Autor:
Nghi H. Nguyen, Abdul Jabbar, Fei Huang, Sean L. McGee, Yaqing Jiao, Abhijit Kundu, Michael J. Palmer, Banfeng Ruan, Bill C.H. Chang, Thuy G. Le, Jonathan B. Baell, Liam G. Hall, Atanu Ghoshal, Lian Xue, Jose F. Garcia-Bustos, Robin B. Gasser, Timothy N. C. Wells, Sarah Preston, Sheree D. Martin
Publikováno v:
Journal of Medicinal Chemistry. 64:840-844
A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the parasitic nematode of sheep, Haemonchus contortus. These compounds did not show overt cytotoxicity to a range of mammalian cell lines under standard in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0ce81985631a42c44c923ffeabc447
https://doi.org/10.1021/acs.jmedchem.0c01793
https://doi.org/10.1021/acs.jmedchem.0c01793
Autor:
Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla
Publikováno v:
J Med Chem
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c8bca2acecd67955624d5564e79816
https://doi.org/10.1021/acs.jmedchem.0c00311
https://doi.org/10.1021/acs.jmedchem.0c00311