THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.

Autor: Jenika D Marshall, Emily R Courage, Ryan F Elliott, Madeline N Fitzpatrick, Anne D Kim, Andrea F Lopez-Clavijo, Bronwyn A Woolfrey, Mireille Ouimet, Michael J O Wakelam, Robert J Brown

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0233180 (2020)

Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and it may promote the progression of atherosclerosis, but the mechanisms behind this process are not completely understood. We previously showed that the phosphorylation of Akt withi

Externí odkaz: https://doaj.org/article/12e6f68f56114505aedddcafff9f7287

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

Autor: Andrew J Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J Faller, Douwe M Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C Bennett, Owen J Sansom, Robert Herd, Robert Jones, Laura M Machesky, Michael J O Wakelam, David A Knecht, Robert H Insall

Publikováno v: PLoS Biology, Vol 12, Iss 10, p e1001966 (2014)

The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potent

Externí odkaz: https://doaj.org/article/d3993f4afdf3405ab98357b4e65f0fe6

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology.

Autor: Marie-Charlotte Domart, Tina M C Hobday, Christopher J Peddie, Gary H C Chung, Alan Wang, Karen Yeh, Nirmal Jethwa, Qifeng Zhang, Michael J O Wakelam, Rudiger Woscholski, Richard D Byrne, Lucy M Collinson, Dominic L Poccia, Banafshé Larijani

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51150 (2012)

The functions and morphology of cellular membranes are intimately related and depend not only on their protein content but also on the repertoire of lipids that comprise them. In the absence of in vivo data on lipid asymmetry in endomembranes, it has

Externí odkaz: https://doaj.org/article/740a89a7ae874dad8993050362785356

The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear

Autor: Rafael M. Kochaj, Elisa Martelletti, Neil J. Ingham, Annalisa Buniello, Bebiana C. Sousa, Michael J. O. Wakelam, Andrea F. Lopez-Clavijo, Karen P. Steel

Publikováno v: Cells; Volume 11; Issue 20; Pages: 3206

Peroxisome biogenesis disorders (due to PEX gene mutations) are associated with symptoms that range in severity and can lead to early childhood death, but a common feature is hearing impairment. In this study, mice carrying Pex3 mutations were found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9597d5cbcdd26c3535434f60825897

Modeling meets metabolomics— the WormJam consensus model as basis for metabolic studies in the model organism Caenorhabditis elegans

Autor: Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J. Joshi, Jake P. N. Hattwell, Paul R. Ebert, Michel van Weeghel, Arwen W. Gao, Michael J. O. Wakelam, Riekelt H. Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E. Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva

Publikováno v: Front. Mol. Biosci. 5:96 (2018)
Frontiers in Molecular Biosciences, 5(NOV):96. Frontiers Media S.A.
Frontiers in Molecular Biosciences, Vol 5 (2018)
Frontiers in Molecular Biosciences

Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena. Despite having been in the focus of research for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebcbf9930fe0a8543996485da8ff6b2
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=54863