Výsledky vyhledávání - "Michael J MacDonald"

Akademický článek

CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells.

Autor: Siriluck Wattanavanitchakorn, Pinnara Rojvirat, Tanit Chavalit, Michael J MacDonald, Sarawut Jitrapakdee

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194252 (2018)

Fructose-1,6-bisphosphatase (FBP1) plays an essential role in gluconeogenesis. Here we report that the human FBP1 gene is regulated by two liver-enriched transcription factors, CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor

Externí odkaz: https://doaj.org/article/f10b99324108457bbdf6ff7408b3fb51

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Akademický článek

X-ray diffraction of metastable structures from supercooled liquid hydrogen

Autor: Luke B. Fletcher, Abraham L. Levitan, Emma E. McBride, Jongjin B. Kim, Eduardo P. Alves, Andrew Aquila, Mungo Frost, Sebastian Goede, Grace King, Thomas J. Lane, Mengning Liang, Michael J. MacDonald, Benjamin K. Ofori-Okai, Christopher Schönwälder, Peihao Sun, Jerome B. Hastings, Sebastien Boutet, Siegfried H. Glenzer

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract We report time resolved observations of the crystallization from liquid hydrogen, supercooled to temperatures below the melting point, using 11.2 keV X-ray diffraction from the Linac Coherent Light Source (LCLS). Changes to the metastable so

Externí odkaz: https://doaj.org/article/59b89c0f3ed9410ba6fc2bbc9576451f

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Akademický článek

Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells.

Autor: Phatchariya Phannasil, Chanitra Thuwajit, Malee Warnnissorn, John C Wallace, Michael J MacDonald, Sarawut Jitrapakdee

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129848 (2015)

Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. We examined the ex

Externí odkaz: https://doaj.org/article/f59e72803eab444098057d993a1d194d

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Akademický článek

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.

Autor: Apilak Wutthisathapornchai, Tuangtong Vongpipatana, Sureeporn Muangsawat, Thirajit Boonsaen, Michael J MacDonald, Sarawut Jitrapakdee

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102730 (2014)

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the gl

Externí odkaz: https://doaj.org/article/507c53d032a44b94be7327a9703dc941

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Akademický článek

Characterization of the distal promoter of the human pyruvate carboxylase gene in pancreatic beta cells.

Autor: Ansaya Thonpho, Pinnara Rojvirat, Sarawut Jitrapakdee, Michael J MacDonald

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e55139 (2013)

Pyruvate carboxylase (PC) is an enzyme that plays a crucial role in many biosynthetic pathways in various tissues including glucose-stimulated insulin secretion. In the present study, we identify promoter usage of the human PC gene in pancreatic beta

Externí odkaz: https://doaj.org/article/36e5cf4785f446dc8a7204afe5e20125

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The data-driven future of high-energy-density physics

Publikováno v: Nature, 593(7859), 351-361
Hatfield, P W, Gaffney, J A, Anderson, G J, Ali, S, Antonelli, L, Başeğmez du Pree, S, Citrin, J, Fajardo, M, Knapp, P, Kettle, B, Kustowski, B, MacDonald, M J, Mariscal, D, Martin, M E, Nagayama, T, Palmer, C A J, Peterson, J L, Rose, S, Ruby, J J, Shneider, C, Streeter, M J V, Trickey, W & Williams, B 2021, ' The data-driven future of high-energy-density physics ', Nature, vol. 593, pp. 351-361 . https://doi.org/10.1038/s41586-021-03382-w
Nature, 593, 351-361

The study of plasma physics under conditions of extreme temperatures, densities and electromagnetic field strengths is significant for our understanding of astrophysics, nuclear fusion and fundamental physics. These extreme physical systems are stron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282476a422c229b06c63609df6a069f5
https://doi.org/10.1038/s41586-021-03382-w

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Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase

Autor: Israrul H. Ansari, Scott W. Stoker, Melissa J. Longacre, Michael J. MacDonald

Publikováno v: Diabetes. 70:1575-1580

Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first-line drug used for the treatment of type 2 diabetes, inhibits liver mGPD 30-50%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e56608cc813e1095ee6338b4401b6d
https://doi.org/10.2337/db20-1143

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Uncovering patterns of freshwater positive interactions using meta‐analysis: Identifying the roles of common participants, invasive species and environmental context

Autor: Benjamin B. Tumolo, Laura A. Burkle, Jose A. Sanchez‐Ruiz, Lindsey K. Albertson, Zachary Maguire, Michael J. MacDonald, Jaris Veneros, Michelle A. Briggs, Sierra Quinn

Publikováno v: Ecology Letters. 24:594-607

Positive interactions are sensitive to human activities, necessitating synthetic approaches to elucidate broad patterns and predict future changes if these interactions are altered or lost. General understanding of freshwater positive interactions ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29ffb1b0cc87e87ec4eacac94d78ca2
https://doi.org/10.1111/ele.13664

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Toward spatio‐temporal delineation of positive interactions in ecology

Autor: Michelle A. Briggs, Sam Carlson, Heidi E. Anderson, Benjamin B. Tumolo, Leonardo Calle, J. Holden Reinert, Lindsey K. Albertson, Michael J. MacDonald

Publikováno v: Ecology and Evolution, Vol 10, Iss 17, Pp 9026-9036 (2020)
Ecology and Evolution

Given unprecedented rates of biodiversity loss, there is an urgency to better understand the ecological consequences of interactions among organisms that may lost or altered. Positive interactions among organisms of the same or different species that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c716b09e548abbbc76da6a27c4ab9d
https://doi.org/10.1002/ece3.6616

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A Novel Intron-Encoded Neuropilin-1 Isoform in Pancreatic Islets Associated With Very Young Age of Onset of Type 1 Diabetes

Autor: Michael J. MacDonald, Israr-ul H. Ansari, Amy S. Riedemann, Scott W. Stoker, Jens C. Eickhoff, Peter J. Chlebeck, Luis A. Fernandez, Melissa J. Longacre

Publikováno v: Diabetes. 71(9)

Net synthesis of pancreatic beta cells peaks before two years of life. Beta cell mass is set within the first five years of life. Inframe translational readthrough of the NRP1 gene exon 9 into intron 9 generates a truncated neuropilin-1 protein lacki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0c650ff919ee359b032fd4b94d43e5
https://pubmed.ncbi.nlm.nih.gov/35713886

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