Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael J M Fischer"'
Autor:
Tina Blažević, Cosmin I Ciotu, Markus Gold-Binder, Elke H Heiss, Michael J M Fischer, Verena M Dirsch
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281191 (2023)
We showed previously that capsaicin, an active compound of chili peppers, can inhibit platelet-derived growth factor-induced proliferation in primary rat vascular smooth muscle cells (VSMCs). The inhibition of BrdU incorporation by capsaicin in these
Externí odkaz:
https://doaj.org/article/4bd5b2936b62482d8e4c4cff87d4e85c
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170097 (2017)
The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) somatosensory neurons and is activated by a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard. Here, we investigate the enhancement of TRPA1
Externí odkaz:
https://doaj.org/article/4ba6580b92474d839c52aeb7c4586ef1
Autor:
Michael J M Fischer, Kailey J Soller, Susanne K Sauer, Joanna Kalucka, Gianluigi Veglia, Peter W Reeh
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123762 (2015)
The formalin test is the most widely used behavioral screening test for analgesic compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study. The chemorecepto
Externí odkaz:
https://doaj.org/article/a2b6316d12a94b7da6cc901d34da7dd0
Autor:
Saskia Wedel, Praveen Mathoor, Oliver Rauh, Tim Heymann, Cosmin I. Ciotu, Dominik C. Fuhrmann, Michael J. M. Fischer, Andreas Weigert, Natasja de Bruin, Felix Hausch, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-21 (2022)
Abstract Background Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy and sometimes severe s
Externí odkaz:
https://doaj.org/article/a1ae3ff5437d4071b8e640f89f13be07
Autor:
Tal Hoffmann, Florian Klemm, Tatjana I Kichko, Susanne K Sauer, Katrin Kistner, Bernhard Riedl, Patrick Raboisson, Lei Luo, Alexandru Babes, Laurence Kocher, Giancarlo Carli, Michael J. M. Fischer, Peter W. Reeh
Publikováno v:
Physiological Reports, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published. In our rat skin‐nerve preparation ex vivo, recording from a
Externí odkaz:
https://doaj.org/article/1914070659d6462b8e34932dd1b49f99
Autor:
Stefan Heber, David Pereyra, Waltraud C. Schrottmaier, Kerstin Kammerer, Jonas Santol, Benedikt Rumpf, Erich Pawelka, Markus Hanna, Alexander Scholz, Markus Liu, Agnes Hell, Klara Heiplik, Benno Lickefett, Sebastian Havervall, Marianna T. Traugott, Matthias J. Neuböck, Christian Schörgenhofer, Tamara Seitz, Christa Firbas, Mario Karolyi, Günter Weiss, Bernd Jilma, Charlotte Thålin, Rosa Bellmann-Weiler, Helmut J. F. Salzer, Gero Szepannek, Michael J. M. Fischer, Alexander Zoufaly, Andreas Gleiss, Alice Assinger
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
ObjectiveTo develop and validate a prognostic model for in-hospital mortality after four days based on age, fever at admission and five haematological parameters routinely measured in hospitalized Covid-19 patients during the first four days after ad
Externí odkaz:
https://doaj.org/article/92908d02a5ae4a5ba5ef80b979f6524a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that affects people of all ages. It is characterized by chronic eczema, constant pruritus, and severe discomfort. AD often progresses from mild annoyance to intract
Externí odkaz:
https://doaj.org/article/f9deaccf21b64342a0fc5614adb2601e
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
A fundamental subdivision of nociceptive sensory neurons is named after their unique sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin-sensitive afferents. The initial excitation by capsaicin of these neur
Externí odkaz:
https://doaj.org/article/55042f0450f34077af63a18c5e8b0f71
Autor:
Christin Schneider, Lisa Gebhardt, Stephanie Arndt, Sigrid Karrer, Julia L. Zimmermann, Michael J. M. Fischer, Anja-Katrin Bosserhoff
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Cold atmospheric plasma (CAP) is a promising approach in anti-cancer therapy, eliminating cancer cells with high selectivity. However, the molecular mechanisms of CAP action are poorly understood. In this study, we investigated CAP effects o
Externí odkaz:
https://doaj.org/article/d6ac0c68457e4130a56c318724b91166
Publikováno v:
Cells, Vol 10, Iss 8, p 2050 (2021)
The group of proton-sensing G-protein coupled receptors (GPCRs) consists of the four receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors are cellular sensors of acidification, a property that has been attributed to the pres
Externí odkaz:
https://doaj.org/article/f7808ce671974532bc7e9c2cb426b3b4