Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Michael J Leone"'
Autor:
Cynthia M. Arokiaraj, Michael J. Leone, Michael Kleyman, Alexander Chamessian, Myung-Chul Noh, BaDoi N. Phan, Bettega C. Lopes, Kelly A. Corrigan, Vijay Kiran Cherupally, Deepika Yeramosu, Michael E. Franusich, Riya Podder, Sumitra Lele, Stephanie Shiers, Byungsoo Kang, Meaghan M. Kennedy, Viola Chen, Ziheng Chen, Hansruedi Mathys, Richard P. Dum, David A. Lewis, Yawar Qadri, Theodore J. Price, Andreas R. Pfenning, Rebecca P. Seal
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114876- (2024)
Summary: Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regio
Externí odkaz:
https://doaj.org/article/3f588436835441efb2ed009e8dffb3e7
Autor:
Ryan A. Tesh, BSc, Haoqi Sun, PhD, Jin Jing, PhD, Mike Westmeijer, MSc, Anudeepthi Neelagiri, MD, Subapriya Rajan, MD, Parimala V. Krishnamurthy, MD, Pooja Sikka, BA, Syed A. Quadri, MD, Michael J. Leone, MSc, Luis Paixao, MD, MSc, Ezhil Panneerselvam, MD, Christine Eckhardt, MD, MSc, Aaron F. Struck, MD, Peter W. Kaplan, MD, Oluwaseun Akeju, MD, Daniel Jones, Eyal Y. Kimchi, MD, PhD, M. Brandon Westover, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 1, p e0611 (2022)
OBJECTIVES:. To develop a physiologic grading system for the severity of acute encephalopathy manifesting as delirium or coma, based on EEG, and to investigate its association with clinical outcomes. DESIGN:. This prospective, single-center, observat
Externí odkaz:
https://doaj.org/article/69544c1060714adc917a0897ea317419
Autor:
Anne Piantadosi, Shibani S. Mukerji, Simon Ye, Michael J. Leone, Lisa M. Freimark, Daniel Park, Gordon Adams, Jacob Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim A. Ahmed, Robert Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, Jesse M. Thon, Cormac M. Kinsella, Eric Rosenberg, Matthew P. Frosch, Marcia B. Goldberg, Tracey A. Cho, Pardis Sabeti
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and often result in severe neurological compromise or death. Traditional diagnostic workflows largely rely on pathogen-specific tests, sometimes over days
Externí odkaz:
https://doaj.org/article/257d13788e6c45d0b65f5a35776fbd4c
Autor:
Shibani S. Mukerji, Sudeshna Das, Haitham Alabsi, Laura N. Brenner, Aayushee Jain, Colin Magdamo, Sarah I. Collens, Elissa Ye, Kiana Keller, Christine L. Boutros, Michael J. Leone, Amy Newhouse, Brody Foy, Matthew D. Li, Min Lang, Melis N. Anahtar, Yu-Ping Shao, Wendong Ge, Haoqi Sun, Virginia A. Triant, Jayashree Kalpathy-Cramer, John Higgins, Jonathan Rosand, Gregory K. Robbins, M. Brandon Westover
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Objectives: Patients with comorbidities are at increased risk for poor outcomes in COVID-19, yet data on patients with prior neurological disease remains limited. Our objective was to determine the odds of critical illness and duration of mechanical
Externí odkaz:
https://doaj.org/article/ce76bda852174f538733f7dccaed55f2
Autor:
Abigail A. Bucklin, Wolfgang Ganglberger, Syed A. Quadri, Ryan A. Tesh, Noor Adra, Madalena Da Silva Cardoso, Michael J. Leone, Parimala Velpula Krishnamurthy, Aashritha Hemmige, Subapriya Rajan, Ezhil Panneerselvam, Luis Paixao, Jasmine Higgins, Muhammad Abubakar Ayub, Yu-Ping Shao, Elissa M. Ye, Brian Coughlin, Haoqi Sun, Sydney S. Cash, B. Taylor Thompson, Oluwaseun Akeju, David Kuller, Robert J. Thomas, M. Brandon Westover
Publikováno v:
Sleep and Breathing. 27:1013-1026
Sleep-disordered breathing may be induced by, exacerbate, or complicate recovery from critical illness. Disordered breathing during sleep, which itself is often fragmented, can go unrecognized in the intensive care unit (ICU). The objective of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741aed962735dafb4e59d36675ba342
https://doi.org/10.1007/s11325-022-02698-9
https://doi.org/10.1007/s11325-022-02698-9
Autor:
Wolfgang Ganglberger, Parimala Velpula Krishnamurthy, Syed A. Quadri, Ryan A. Tesh, Abigail A. Bucklin, Noor Adra, Madalena Da Silva Cardoso, Michael J. Leone, Aashritha Hemmige, Subapriya Rajan, Ezhil Panneerselvam, Luis Paixao, Jasmine Higgins, Muhammad Abubakar Ayub, Yu-Ping Shao, Brian Coughlin, Haoqi Sun, Elissa M. Ye, Sydney S. Cash, B. Taylor Thompson, Oluwaseun Akeju, David Kuller, Robert J. Thomas, M. Brandon Westover
Publikováno v:
Frontiers in Network Physiology. 3
Introduction: To measure sleep in the intensive care unit (ICU), full polysomnography is impractical, while activity monitoring and subjective assessments are severely confounded. However, sleep is an intensely networked state, and reflected in numer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e05119c5d908792e8b213bd6889267
https://doi.org/10.3389/fnetp.2023.1120390
https://doi.org/10.3389/fnetp.2023.1120390
Autor:
Elissa Ye, Lawrence W. Stratton, Jayashree Kalpathy-Cramer, Yu Ping Shao, Jonathan Rosand, Wolfgang Ganglberger, James B. Meigs, Jacqueline T. Chu, Shibani S. Mukerji, M. Brandon Westover, Christine L. Boutros, Haitham Alabsi, Ingrid V. Bassett, Wendong Ge, Sarah I. Collens, Haoqi Sun, Ryan A. Tesh, Bruce Fischl, Ruopeng Wang, Laura N. Brenner, Matthew D. Li, Gregory K. Robbins, Michael Dougan, Aayushee Jain, Colin Magdamo, Sudeshna Das, Michael J. Leone
Publikováno v:
The Journal of Infectious Diseases
Background We sought to develop an automatable score to predict hospitalization, critical illness, or death for patients at risk for coronavirus disease 2019 (COVID-19) presenting for urgent care. Methods We developed the COVID-19 Acuity Score (CoVA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a6f4672fec25c7c2c324051b516ddc
https://doi.org/10.1093/infdis/jiaa663
https://doi.org/10.1093/infdis/jiaa663
Autor:
Oluwaseun Akeju, Anudeepthi Neelagiri, Luis Paixao, Mike Westmeijer, Ezhil Panneerselvam, Parimala Velpula Krishnamurthy, Meike van Sleuwen, Ryan A. Tesh, Michael J. Leone, Syed A. Quadri, Christine Eckhardt, M. Brandon Westover, Subapriya Rajan, Eyal Y. Kimchi, Pooja Sikka, Haoqi Sun
Publikováno v:
Crit Care Med
OBJECTIVES: Delirium is a common and frequently underdiagnosed complication in acutely hospitalized patients, and its severity is associated with worse clinical outcomes. We propose a physiologically based method to quantify delirium severity as a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e580213dd48be2766be168499aadfb
https://europepmc.org/articles/PMC8678335/
https://europepmc.org/articles/PMC8678335/
Autor:
A.R. Hemmige, Luis Paixao, M.B. Westover, S. Rajan, Parimala Velpula Krishnamurthy, Syed A. Quadri, Ezhil Panneerselvam, M. Da Silva Cardoso, Noor Adra, M. A. Ayub, Oluwaseun Akeju, Ryan A. Tesh, Haoqi Sun, B. Coughlin, Yu-Ping Shao, Wolfgang Ganglberger, Elissa Ye, S. Sydney Cash, Abigail A. Bucklin, Michael J. Leone, Robert J. Thomas, B. T. Thompson, David Kuller, John M. Higgins
BackgroundFull polysomnography, the gold standard of sleep measurement, is impractical for widespread use in the intensive care unit (ICU). Wrist-worn actigraphy and subjective sleep assessments do not measure sleep physiology adequately. Here, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe7760133df8cae279ce0ea6768c2117
https://doi.org/10.1101/2021.09.23.21264039
https://doi.org/10.1101/2021.09.23.21264039
Autor:
Jacob E. Lemieux, Tracey A. Cho, Matthew P. Frosch, Daniel J. Park, Gordon Adams, Isaac H. Solomon, Pardis C. Sabeti, Eric S. Rosenberg, Asim A. Ahmed, Bridget Ostrem, Kaelyn C. Cummins, Marcia B. Goldberg, Robert B. Goldstein, Michael J. Leone, Sanjat Kanjilal, Jesse M. Thon, Vijay S. Ganesh, Cormac M. Kinsella, Shibani S. Mukerji, Lisa Freimark, Anne Piantadosi, Simon Ye
Publikováno v:
mBio
mBio, Vol 12, Iss 4 (2021)
mBio, Vol 12, Iss 4 (2021)
Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and often result in severe neurological compromise or death. Traditional diagnostic workflows largely rely on pathogen-specific tests, sometimes over days to weeks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c19d71282a5f9578f48f486383d1fa3
https://doi.org/10.1128/mbio.01143-21
https://doi.org/10.1128/mbio.01143-21