Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michael J Hobbs"'
Autor:
Mark R. Harpel, Ghotas Evindar, Shenaz Bunally, David G. Washburn, Steve Wilson, Joanne Prendergast, Scott G. Summerfield, Katrina Rivera, Chun-wa Chung, Julien C. Vantourout, Steven R. Skinner, Neil Young, Xiaopeng Bai, Christopher C. Arico-Muendel, Albert Isidro-Llobet, Rakesh Lad, William Traylen, Graham L. Simpson, Josephine Yuen, Letian Kuai, Paul Scott-Stevens, Kim Lambert, Sandeep Pal, Saul Needle, Andrew M. Mason, Michael J Hobbs, Emma V. Edgar, Richard Snell, Lara S. Kallander, Eric X Shi, Lisa M. Shewchuk, Dennis A. Holt, Allan J. B. Watson
Publikováno v:
Bioconjugate Chemistry. 32:279-289
Reducing the required frequence of drug dosing can improve the adherence of patients to chronic treatments. Hence, drugs with longer in vivo half-lives are highly desirable. One of the most promising approaches to extend the in vivo half-life of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b213e0b311b3358e0c31efff0d5b13f
https://doi.org/10.1021/acs.bioconjchem.0c00662
https://doi.org/10.1021/acs.bioconjchem.0c00662
Publikováno v:
Journal of pharmaceutical sciences. 109(3)
Dutasteride is prescribed as a once-daily oral capsule for the treatment of symptomatic benign prostatic hyperplasia. As an alternative and patient-focused drug product, this laboratory evaluated the potential to deliver dutasteride in a controlled/s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0508ae88287623e3cdd364b8ec66f57f
https://pubmed.ncbi.nlm.nih.gov/31751565
https://pubmed.ncbi.nlm.nih.gov/31751565
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(8)
1. In a clinical trial, a strong drug–drug interaction (DDI) was observed between dextromethorphan (DM, the object or victim drug) and GSK1034702 (the precipitant or perpetrator drug), following single and repeat doses. This study determined the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0159409f18fcb7c0c0daf3bf3cd113e3
https://pubmed.ncbi.nlm.nih.gov/27910730
https://pubmed.ncbi.nlm.nih.gov/27910730
Autor:
Rolf W. Sparidans, Evita van de Steeg, Els Wagenaar, Dilek Iusuf, Michael J Hobbs, Alfred H. Schinkel, Jos H. Beijnen, Anita van Esch, Kathryn E. Kenworthy
Publikováno v:
Molecular Pharmaceutics. 9:2497-2504
Organic anion-transporting polypeptides (OATPs) mediate the hepatic uptake of many drugs. Hepatic uptake is crucial for the therapeutic effect of pravastatin, a cholesterol-lowering drug and OATP1A/1B substrate. We aimed to gain empirical insight int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b91ed806ae54f21a827b6fcad22a361
https://doi.org/10.1021/mp300108c
https://doi.org/10.1021/mp300108c
Autor:
Michael J Hobbs, Maxine A. Taylor, Alfred H. Schinkel, Kathryn E. Kenworthy, Dilek Iusuf, Els Wagenaar, Anita van Esch, Evita van de Steeg
Publikováno v:
Molecular pharmacology. 83(5)
Organic anion-transporting polypeptides (OATPs) mediate the liver uptake and hence plasma clearance of a broad range of drugs. For rosuvastatin, a cholesterol-lowering drug and OATP1A/1B substrate, the liver represents both its main therapeutic targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c02f2dccc0d48bd8187a715bc21a7ce
https://pubmed.ncbi.nlm.nih.gov/23429889
https://pubmed.ncbi.nlm.nih.gov/23429889
Autor:
Catherine M. Cartwright, Michael Gertz, Kathryn E. Kenworthy, Aleksandra Galetin, Michael J Hobbs, Malcolm Rowland, J. Brian Houston
Publikováno v:
Pharmaceutical research. 30(3)
To apply physiologically-based pharmacokinetic (PBPK) modeling to investigate the consequences of reduction in activity of hepatic and intestinal uptake and efflux transporters by cyclosporine and its metabolite AM1. Inhibitory potencies of cyclospor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0093d752e71d01ea06935b16db960204
https://pubmed.ncbi.nlm.nih.gov/23179780
https://pubmed.ncbi.nlm.nih.gov/23179780
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 42(4)
The role of hepatic uptake (Oatp1a1 and Oatp1b4) and efflux (Bcrp and Mrp2) transporters in the disposition of rosuvastatin were investigated using the isolated perfused rat liver (IPRL). A simple physiologically-based pharmacokinetic model was devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b127ef6cab8576dad17150147b0650
https://pubmed.ncbi.nlm.nih.gov/22035568
https://pubmed.ncbi.nlm.nih.gov/22035568
Publikováno v:
Biochemical Pharmacology. 45:1769-1774
In this study, we have used a rat lung slice model to compare the ability to several potential cysteine delivery systems (L-cysteine isopropylester, L-cysteine cyclohexylester, N-acetylcysteine, L,2-oxo-4-thiazolidine carboxylic acid and cysteine) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2f04ce7df1e0705ee82875fe75599e
https://doi.org/10.1016/0006-2952(93)90432-v
https://doi.org/10.1016/0006-2952(93)90432-v
Publikováno v:
Biochemical pharmacology. 55(10)
In this study, we have compared the uptake of l -cysteine ( l -CySH), d -cysteine ( d -CySH), l -cysteine isopropyl ester ( l -CIPE) and d -cysteine isopropyl ester ( d -CIPE) in rat lung slices and tracheal sections and determined the effectiveness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54dce441aea30cc0dc603504d93c3ad
https://pubmed.ncbi.nlm.nih.gov/9633993
https://pubmed.ncbi.nlm.nih.gov/9633993
Publikováno v:
Humanexperimental toxicology. 15(8)
1 Sulphur mustard reacts directly with benzenethiols and cysteine esters in aqueous medium. 2 Benzenethiols diffuse into lung slices in short term culture. 3 Treatment of lung slices in short term culture with benzenethiols does not protect cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003a67f73cedb672e126d5b256bf01e3
https://pubmed.ncbi.nlm.nih.gov/8863055
https://pubmed.ncbi.nlm.nih.gov/8863055