Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Michael J Griffiths"'
Autor:
Sylviane Defres, Kukatharmini Tharmaratnam, Benedict D Michael, Mark Ellul, Nicholas W S Davies, Ava Easton, Michael J Griffiths, Maneesh Bhojak, Kumar Das, Hayley Hardwick, Chris Cheyne, Rachel Kneen, Antonieta Medina-Lara, Anne Christine Salter, Nicholas J Beeching, Enitan Carrol, Angela Vincent, ENCEPH UK study group, Marta Garcia-Finana, Tom Solomon
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0282645 (2023)
ObjectivesEncephalitis, brain inflammation and swelling, most often caused by an infection or the body's immune defences, can have devastating consequences, especially if diagnosed late. We looked for clinical predictors of different types of encepha
Externí odkaz:
https://doaj.org/article/1fe7c14878c24bb1be143a4004ba417b
Autor:
Alish B Palmos, Vincent Millischer, David K Menon, Timothy R Nicholson, Leonie S Taams, Benedict Michael, Geraint Sunderland, Michael J Griffiths, COVID Clinical Neuroscience Study Consortium, Christopher Hübel, Gerome Breen
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010042 (2022)
In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need
Externí odkaz:
https://doaj.org/article/a6fb1a0726e8492bae4cdaa86998c8e1
Autor:
Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, John C Hartley, Michaela Brown, Tracy Moitt, Joanne Dalton, Tom Kearns, Michael J Griffiths, Giovanna Culeddu, Tom Solomon, Dyfrig Hughes, Carrol Gamble, the BASICS study collaborators
Publikováno v:
Health Technology Assessment, Vol 24, Iss 17 (2020)
Background: Insertion of a ventriculoperitoneal shunt to treat hydrocephalus is one of the most common neurosurgical procedures worldwide. Shunt infection affects up to 15% of patients, resulting in long hospital stays, multiple surgeries and reduced
Externí odkaz:
https://doaj.org/article/ef472f04f29b422db05a4f1fcf747366
Autor:
Jennifer Lemon, Jessie Cooper, Sylviane Defres, Ava Easton, Manish Sadarangani, Michael J Griffiths, Andrew J Pollard, Tom Solomon, Rachel Kneen
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0220042 (2019)
BackgroundEncephalitis, characterised as inflammation of the brain tissue, is an important cause of acquired brain injury in children. Objective clinical outcomes vary significantly between affected patients, however they do not always correlate with
Externí odkaz:
https://doaj.org/article/e5d6616b54c447f08c7abccce4b60a0c
Autor:
Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera, Mark Ellul, Marcus Tulius Texeira da Silva, Anna Rosala-Hallas, Marcia Rodrigues Jardim, Girvan Burnside, Luciana Pamplona, Maneesh Bhojak, Radhika Manohar, Gabriel Amorelli Medeiros da Silva, Marcus Vinicius Adriano, Patricia Brasil, Rita Maria Ribeiro Nogueira, Carolina Cardoso Dos Santos, Lance Turtle, Patricia Carvalho de Sequeira, David W Brown, Michael J Griffiths, Ana Maria Bispo de Filippis, Tom Solomon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006212 (2018)
BackgroundDuring 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikun
Externí odkaz:
https://doaj.org/article/5ef1adb97177473f99e214a676114b3f
Autor:
Cheryl Hemingway, Maurice Berk, Suzanne T Anderson, Victoria J Wright, Shea Hamilton, Hariklia Eleftherohorinou, Myrsini Kaforou, Greg M Goldgof, Katy Hickman, Beate Kampmann, Johan Schoeman, Brian Eley, David Beatty, Sandra Pienaar, Mark P Nicol, Michael J Griffiths, Simon J Waddell, Sandra M Newton, Lachlan J Coin, David A Relman, Giovanni Montana, Michael Levin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185973 (2017)
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the immune sys
Externí odkaz:
https://doaj.org/article/98998fabc3a442a9a50a5b8bae671501
Autor:
Benedict D Michael, Michael J Griffiths, Julia Granerod, David Brown, Nicholas W S Davies, Ray Borrow, Tom Solomon
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146288 (2016)
BACKGROUND:Encephalitis is parenchymal brain inflammation due to infectious or immune-mediated processes. However, in 15-60% the cause remains unknown. This study aimed to determine if the cytokine/chemokine-mediated host response can distinguish inf
Externí odkaz:
https://doaj.org/article/369f9757c4e7487995a35275deb58586
Autor:
Michael J Griffiths, Jennifer V Lemon, Ajit Rayamajhi, Prakash Poudel, Pramina Shrestha, Vijay Srivastav, Rachel Kneen, Antonieta Medina-Lara, Rupa R Singh, Tom Solomon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2383 (2013)
Over 133,000 children present to hospitals with Acute Encephalitis Syndrome (AES) annually in Asia. Japanese encephalitis (JE) accounts for approximately one-quarter of cases; in most cases no pathogen is identified and management is supportive. Alth
Externí odkaz:
https://doaj.org/article/a66a506d8498462abc15525c7b30bd55
Autor:
Simon J Waddell, Stephen J Popper, Kathleen H Rubins, Michael J Griffiths, Patrick O Brown, Michael Levin, David A Relman
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9753 (2010)
Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and indirect effects, and of homotypic and heterotypic cell
Externí odkaz:
https://doaj.org/article/ade2d330b1f64b7faa6e6a713d35b5e8
Autor:
Valentina D Mangano, Taane G Clark, Sarah Auburn, Susana Campino, Mahamadou Diakite, Andrew E Fry, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Michael J Griffiths, Charles Newton, Norbert Peshu, Thomas N Williams, Kevin Marsh, Malcolm E Molyneux, Terrie E Taylor, David Modiano, Dominic P Kwiatkowski, Kirk A Rockett
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4206 (2009)
Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signall
Externí odkaz:
https://doaj.org/article/65a55f982fa0475cad6015d99ba4909a