Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Michael J Greenberg"'
Autor:
Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Publikováno v:
eLife, Vol 12 (2023)
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least
Externí odkaz:
https://doaj.org/article/376094e3254c440f9fdb0628df390ca2
Publikováno v:
eLife, Vol 9 (2020)
Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However,
Externí odkaz:
https://doaj.org/article/a55697cfd1e6486e9b1c8264c308fb3b
Autor:
Jennifer McAdow, Shuo Yang, Tiffany Ou, Gary Huang, Matthew B. Dobbs, Christina A. Gurnett, Michael J. Greenberg, Aaron N. Johnson
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Nemaline myopathy (NM) is the most common congenital myopathy, characterized by extreme weakness of the respiratory, limb, and facial muscles. Pathogenic variants in Tropomyosin 2 (TPM2), which encodes a skeletal muscle–specific actin binding prote
Externí odkaz:
https://doaj.org/article/ba6c69f778b743b2900f4c656ecda107
Autor:
Samantha K. Barrick, Ankit Garg, Lina Greenberg, Shanshan Zhang, Chieh-Yu Lin, Nathan O. Stitziel, Michael J. Greenberg
Publikováno v:
Journal of Molecular and Cellular Cardiology. 176:58-67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de07468a4fd34752952dedcde467643b
https://doi.org/10.1016/j.yjmcc.2023.01.014
https://doi.org/10.1016/j.yjmcc.2023.01.014
Autor:
Michael S. Woody, Michael J. Greenberg, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin
Externí odkaz:
https://doaj.org/article/a390d9a0840145559f69f13c5f0635e6
Autor:
Sarah R. Clippinger Schulte, Brent Scott, Samantha K. Barrick, W. Tom Stump, Thomas Blackwell, Michael J. Greenberg
Publikováno v:
Biophysical Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2e81ec20b5a73d3f5c9563ae6858b5a
https://doi.org/10.1016/j.bpj.2023.05.008
https://doi.org/10.1016/j.bpj.2023.05.008
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Heart failure is the leading cause of death in the western world and as such, there is a great need for new therapies. Heart failure has a variable presentation in patients and a complex etiology; however, it is fundamentally a condition that affects
Externí odkaz:
https://doaj.org/article/a5c82d7558aa4450ad59d43a3c1b06ed
Autor:
Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baf0065e922a07922b9b71aa51f6b7c7
https://doi.org/10.7554/elife.83602.sa2
https://doi.org/10.7554/elife.83602.sa2
Autor:
Sayli S. Modak, Lina Greenberg, William Stump, Weikai Li, Nathaniel Huebsch, Michael J. Greenberg
Publikováno v:
Biophysical Journal. 122:453a-454a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a526377e093e7709616acfce08c838
https://doi.org/10.1016/j.bpj.2022.11.2441
https://doi.org/10.1016/j.bpj.2022.11.2441
Autor:
Artur Meller, Jeffrey M. Lotthammer, Louis G. Smith, Borna Novak, Lindsey A. Lee, Catherine C. Kuhn, Lina Greenberg, Leslie A. Leinwand, Michael J. Greenberg, Gregory R. Bowman
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc4bdc82f87b72d6bdd502517eef091
https://doi.org/10.1101/2022.09.05.506254
https://doi.org/10.1101/2022.09.05.506254