Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Michael J Gough"'
Autor:
David Friedman, Marka Crittenden, Michael J Gough, Jason Baird, Alejandro Alice, Megan Ball, Gwen Kramer, Aanchal Preet Kaur
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a133744d121d434481d281930d5422ce
Autor:
Brady Bernard, Venkatesh Rajamanickam, Christopher Dubay, Brian Piening, Emilio Alonso, Zeljka Jutric, Ephraim Tang, Pippa Newell, Paul Hansen, Terry Medler, Andrew Gunderson, Kristina Young, Carlo Bifulco, Joanna Pucliowska, Marka R Crittenden, Michael J Gough
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238380 (2020)
Pancreatic adenocarcinoma is characterized by a complex tumor environment with a wide diversity of infiltrating stromal and immune cell types that impact the tumor response to conventional treatments. However, even in this poorly responsive tumor the
Externí odkaz:
https://doaj.org/article/5c004b2d3cea43c3beb6c0bf1de29cb1
Autor:
Lauren Zebertavage, Shelly Bambina, Jessica Shugart, Alejandro Alice, Kyra D Zens, Peter Lauer, Bill Hanson, Michael J Gough, Marka R Crittenden, Keith S Bahjat
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209153 (2019)
Dysregulated signaling via the epidermal growth factor receptor (EGFR)-family is believed to contribute to the progression of a diverse array of cancers. The most common variant of EGFR is EGFRvIII, which results from a consistent and tumor-specific
Externí odkaz:
https://doaj.org/article/4c25820ef0e34565971f0f5e86283508
Autor:
Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Michaela Phillips, Alejandro Alice, Shelly Bambina, Lauren Zebertavage, David Friedman, Benjamin Cottam, Pippa Newell, Michael J Gough, Marka R Crittenden, Pieter Van der Veken, Kristina H Young
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211117 (2019)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune esc
Externí odkaz:
https://doaj.org/article/2e99967ed537478dbb6b319acc802e12
Autor:
Jason R Baird, Zipei Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192988 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0187532.].
Externí odkaz:
https://doaj.org/article/5abae6eefde5466c976a3b51dbf5f03c
STING expression and response to treatment with STING ligands in premalignant and malignant disease.
Autor:
Jason R Baird, Zipei Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187532 (2017)
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinuc
Externí odkaz:
https://doaj.org/article/815182376ef848c39cf32cc4867e97d3
Autor:
Gwen Kramer, Tiffany Blair, Shelly Bambina, Aanchal Preet Kaur, Alejandro Alice, Jason Baird, David Friedman, Alexa K. Dowdell, Michio Tomura, Clemens Grassberger, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has the potential to eliminate the tumor-specific T cells in fiel
Externí odkaz:
https://doaj.org/article/921a05abf75b46bca345c3b931ab641e
Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy.
Autor:
Kristina H Young, Jason R Baird, Talicia Savage, Benjamin Cottam, David Friedman, Shelly Bambina, David J Messenheimer, Bernard Fox, Pippa Newell, Keith S Bahjat, Michael J Gough, Marka R Crittenden
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157164 (2016)
The anecdotal reports of promising results seen with immunotherapy and radiation in advanced malignancies have prompted several trials combining immunotherapy and radiation. However, the ideal timing of immunotherapy with radiation has not been clari
Externí odkaz:
https://doaj.org/article/2781218293ae4eadb113a4a1d59defb7
Autor:
Marka R Crittenden, Talicia Savage, Benjamin Cottam, Keith S Bahjat, William L Redmond, Shelly Bambina, Melissa Kasiewicz, Pippa Newell, Andrew M Jackson, Michael J Gough
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69527 (2013)
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen
Externí odkaz:
https://doaj.org/article/f186f44cfd354180954eea7fe5da8f19
Autor:
Marka R Crittenden, Benjamin Cottam, Talicia Savage, Cynthia Nguyen, Pippa Newell, Michael J Gough
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39295 (2012)
Radiation therapy aims to kill cancer cells with a minimum of normal tissue toxicity. Dying cancer cells have been proposed to be a source of tumor antigens and may release endogenous immune adjuvants into the tumor environment. For these reasons, ra
Externí odkaz:
https://doaj.org/article/97e5e31feaef4c54a3fffb274b2ef53f