Výsledky vyhledávání - "Michael J Gerst"

Overexpression of phospholamban in slow‐twitch skeletal muscle is associated with depressed contractile function and muscle remodeling

Autor: Karen B. Young, Evangelia G. Kranias, Michael J Gerst, James Gulick, Jeffrey Robbins, Qiujing Song, Guoxiang Chu, Ingrid L. Grupp

Publikováno v: The FASEB Journal. 18:974-976

The relative amount of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and its crucial inhibitor phospholamban (PLN) are closely regulated and play a pivotal role in maintaining muscle function. The functional importance of PLN has been intensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7371dde9960fa1cba900e5ae6d4576
https://doi.org/10.1096/fj.03-1058fje

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Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy

Autor: Vivek J. Kadambi, Rajesh Dash, Evangelia G. Kranias, Anand Pathak, Danuta Biniakiewicz, Michael J Gerst, Albrecht Schmidt, Brian D. Hoit, William T. Abraham

Publikováno v: Cardiovascular research. 57(3)

Objective: Exogenous catecholamine exposure has been associated with p38 mitogen-activated protein kinase (MAPK) and cardiac hypertrophy. In this study, we investigated the regulation of p38 MAPK in cardiac remodeling elicited by endogenous adrenergi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8f5a5fc2db59e0abb854f0510c5d7e
https://pubmed.ncbi.nlm.nih.gov/12618232

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Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state

Autor: Evangelia G. Kranias, Muthu Periasamy, Michael J Gerst, Yong Ji, Albrecht Schmidt, Konrad Frank, Wen Zhao, Guoxiang Chu

Publikováno v: Cardiovascular research. 57(1)

Objective: Phospholamban ablation or ectopic expression of SERCA1a in the heart results in significant increases in cardiac contractile parameters. The aim of the present study was to determine whether a combination of these two genetic manipulations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f3cac619a21bf2538f832e5c28ef3e
https://pubmed.ncbi.nlm.nih.gov/12504816

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Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis

Autor: Helen Kiriazis, Yoji Sato, Evangelia G. Kranias, Brian D. Hoit, Albrecht Schmidt, Michael J Gerst, Vivek J. Kadambi

Publikováno v: Cardiovascular research. 53(2)

Objective: To determine whether the hyperdynamic phospholamban-knockout hearts are capable of withstanding a chronic aortic stenosis. Methods: The transverse section of the aorta was banded in phospholamban-knockout and their isogenic wild-type mice,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc9c4c17d7c8f85c90270c0f8d58a61
https://pubmed.ncbi.nlm.nih.gov/11827688

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Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality

Autor: Danuta Biniakiewicz, Michael J. Gerst, Stephen B. Liggett, Gerald W. Dorn, Vivek J. Kadambi, Rajesh Dash, Evangelia G. Kranias, John N. Lorenz, William T. Abraham, Nicole M. Tepe, Brian D. Hoit, Amy M. Canning, Albrecht Schmidt

Publikováno v: Circulation. 103(6)

Background —Relieving the inhibition of sarcoplasmic reticular function by phospholamban is a major target of β-adrenergic stimulation. Chronic β-adrenergic receptor activity has been suggested to be detrimental, on the basis of transgenic overex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c93e02caa2496422abb385f320e3b43
https://pubmed.ncbi.nlm.nih.gov/11171783

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