Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen

Autor: Po-Chang Chiang, Jia Liu, Karthik Nagapudi, Ricky Wu, Michael J Dolton, Niloufar Salehi, Gregory Amidon

Publikováno v: Journal of Pharmaceutical Sciences. 111:2018-2029

Nowadays, the ever-increasing costs of research and development in the pharmaceutical industry have created a big demand for predicting the performances of drug candidates. Of those, the desire to establish an in vitro-in vivo correlation (IVIVC) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800e13e34a4f10135006a8bd0043ecce
https://doi.org/10.1016/j.xphs.2022.01.024

Safety, Tolerability, and Pharmacokinetics of High‐Volume Subcutaneous Crenezumab, With and Without Recombinant Human Hyaluronidase in Healthy Volunteers

Autor: Amanda Roden, Nan Hu, Logan Brooks, Monica K Wetzel-Smith, Montserrat Carrasco-Triguero, Geoffrey A. Kerchner, Michael J. Dolton, Kathleen Blondeau, Jill Smith, Ariel Waitz, Anita Moein, Kaycee M Sink, Angelica Quartino, Aaron Chesterman, Kun Peng, Ajay Deshmukh, Susanne Ostrowitzki

Publikováno v: Clinical Pharmacology & Therapeutics. 110:1337-1348

Compared with intravenous formulations, subcutaneous (s.c.) formulations of therapeutic monoclonal antibodies may provide increased patient access and more convenient administration options, although historically high-volume s.c. administration (> 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b222931c1ce53bd4112e16a60b1ec2
https://doi.org/10.1002/cpt.2385

Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport

Autor: Michael J. Dolton, Po-Chang Chiang, Yuan Chen

Publikováno v: Journal of Pharmaceutical Sciences. 110:1427-1430

Absorption via the intestinal lymphatic system is known to be important for some highly lipophilic compounds, and can be associated with unique pharmacokinetic properties due to evasion of hepatic first-pass metabolism. This work aimed to develop a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d85b9c155e96f4681eff6dd1210730
https://doi.org/10.1016/j.xphs.2020.12.023

Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations

Autor: Nicolas Simon, Pieter Colin, Dolores Santos-Buelga, Karel Allegaert, Michael J. Dolton, Michel Struys, Alison H. Thomson, Daniel J. Touw, Jason A. Roberts, Fabio Silvio Taccone, Ana Martín-Suárez, Matthijs de Hoog, Emilia Barcia, Masato Yamamoto, Lo Yl, Douglas J. Eleveld, Eyob Adane

Publikováno v: Clinical Pharmacokinetics, 58(6), 767-780. Adis
Clinical Pharmacokinetics, 58(6), 767-780. Springer International Publishing AG
Clinical Pharmacokinetics
Clinical Pharmacokinetics, Springer Verlag, 2019, 58 (6), pp.767-780. ⟨10.1007/s40262-018-0727-5⟩
Clinical pharmacokinetics, 58 (6
CLINICAL PHARMACOKINETICS

Background and Objectives: Uncertainty exists regarding the optimal dosing regimen for vancomycin in different patient populations, leading to a plethora of subgroup-specific pharmacokinetic models and derived dosing regimens. We aimed to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba270c934ce37363a6f6e9c7e35d91e
https://doi.org/10.1007/s40262-018-0727-5

Population repeated time-to-event analysis of exacerbations in asthma patients : A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires

Autor: Mats O. Karlsson, Angelica Quartino, Dorothy Cheung, Naoki Kotani, Tracy Staton, Robin J Svensson, Jakob Ribbing, Michael J. Dolton, Jin Jin, Shweta Vadhavkar, Nageshwar Budha, Rui Zhu, Wendy S. Putnam, David F. Choy

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1221-1235 (2021)

Identification of covariates, including biomarkers, spirometry, and diaries/questionnaires, that predict asthma exacerbations would allow better clinical predictions, shorter phase II trials and inform decisions on phase III design, and/or initiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9d584d9a6d468a9120bcdaeb74ab58
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468872