Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Michael J Detke"'
Autor:
Amy S Chappell, Laurence A Bradley, Curtis Wiltse, Michael J Detke, Deborah N D’Souza, Michael Spaeth
Publikováno v:
International Journal of General Medicine, Vol 2008, Iss default, Pp 91-102 (2008)
Amy S Chappell1, Laurence A Bradley2, Curtis Wiltse1, Michael J Detke1,3,4, Deborah N D’Souza1, Michael Spaeth51Lilly Research Laboratories, Indianapolis, IN, USA; 2University of Alabama at Birmingham, Birmingham, Alabama, USA; 3Indiana University
Externí odkaz:
https://doaj.org/article/32bad8d79e144510927c33179e33c3d9
Autor:
Sean Broce, Florian Ermini, Leslie J. Holsinger, Stephen S. Dominy, Michael J. Detke, Leo Rodriguez, Ursula Haditsch, Casey C. Lynch, D. David Hennings, Mai Nguyen, Jianhong Wang, Shirin Arastu-Kapur, Debasish Raha
Publikováno v:
SSRN Electronic Journal.
Gingipains are protease virulence factors from the periodontal bacterial pathogen Porphyromonas gingivalis and were recently identified in greater than 90% of Alzheimer’s disease (AD) brains. Studies in wild-type mice and rats have demonstrated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a149865216c563f272cfec2516f79be
https://doi.org/10.2139/ssrn.3838996
https://doi.org/10.2139/ssrn.3838996
Autor:
Michael J. Detke, Sharon Rosenzweig-Lipson, Janet B. W. Williams, Earl L. Giller, John M. Kane, Joan H.Q. Shen, Danielle Popp, Yonggang Zhao
Publikováno v:
Journal of Psychiatric Research. 53:14-22
Vabicaserin, a potent 5-HT2C receptor agonist, decreases nucleus accumbens extracellular dopamine levels in rats, without affecting striatal dopamine, indicating mesolimbic selectivity. This is the first study of efficacy, safety and tolerability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde4ea53e002c5370eab45d0b731ff91
https://doi.org/10.1016/j.jpsychires.2014.02.012
https://doi.org/10.1016/j.jpsychires.2014.02.012
Publikováno v:
Pharmaceutical Medicine. 28:53-65
Placebo response impacts the development of treatments for central nervous system disorders. Despite significant attention in scientific literature, the magnitude of placebo response continues to increase. The present work reviews empirical and theor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c215c51705a4731abb7a41392d1ea3c2
https://doi.org/10.1007/s40290-014-0052-8
https://doi.org/10.1007/s40290-014-0052-8
Autor:
Michael J. Detke, Graeme Eisenhofer, Jill Chappell, Robert A. Dean, Mary Pat Knadler, D. Richard Lachno, Malcolm I. Mitchell, Beth A. Pangallo, Smriti Iyengar, Evelyn D. Lobo, Charles B. Nemeroff, Harry Haber, Michael J. Owens
Publikováno v:
Journal of Clinical Psychopharmacology. 34:9-16
Duloxetine selectively inhibits the serotonin (5-HT) and norepinephrine (NE) transporters (5-HTT and NET, respectively), as demonstrated in vitro and in preclinical studies; however, transporter inhibition has not been fully assessed in vivo at the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bf9b0c8eadbb1ebddaaaf8e9eef41f
https://doi.org/10.1097/jcp.0000000000000061
https://doi.org/10.1097/jcp.0000000000000061
Autor:
Ryan Wright, Jill Chappell, Malcolm I. Mitchell, Richard Kovacs, Harry Haber, Beth A. Pangallo, Michael J. Detke
Publikováno v:
Journal of Clinical Psychopharmacology. 33:236-239
A decrease in heart rate variability (HRV) can indicate increased sympathetic nervous system activity and possibly increased norepinephrine levels. In this randomized, placebo- and escitalopram (ESC)-controlled, subject-blind, 2-period, crossover stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee9e769391bf1ad2a2cb0b5e6475d27
https://doi.org/10.1097/jcp.0b013e31828567b6
https://doi.org/10.1097/jcp.0b013e31828567b6
Autor:
Michael J. Detke, Constance Weisner, Tatiana Ramey, Eric C. Strain, Phil Skolnick, Robert H. Dworkin, Shengan Lai, Joanne B. Fertig, David J. McCann, Kenneth Silverman, Ivan D. Montoya, Raye Z. Litten, Megan L. Ryan, Brian D. Kiluk, Kyle M. Kampman, Jennifer S. Gewandter, Amy M. Duhig, Daniel E. Falk, Kelly E. Dunn, George E. Woody, Kathleen M. Carroll, F. Gerard Moeller, Kenzie L. Preston, Redonna K. Chandler
Background The development and approval of an efficacious pharmacotherapy for stimulant use disorders has been limited by the lack of a meaningful indicator of treatment success, other than sustained abstinence. Methods In March, 2015, a meeting spon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac1fd56135799c94b89497c511011b5
https://escholarship.org/uc/item/1j83k4p9
https://escholarship.org/uc/item/1j83k4p9
Autor:
Craig H. Mallinckrodt, William R. Prucka, Michael J. Detke, Geert Molenberghs, Stephen J. Ruberg
Publikováno v:
Drug Information Journal. 44:431-441
Active comparators are often included in phase 2 studies as a positive control to assess assay sensitivity, but inclusion of a positive control does not necessarily improve decision making. Examples show that positive controls are more useful in asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94451a7e87229d6b5c6da6af540470b5
https://doi.org/10.1177/009286151004400407
https://doi.org/10.1177/009286151004400407
Autor:
Amy S. Chappell, Miroslav Backonja, Michael J. Detke, Joseph H. Atkinson, Qi Zhang, Smriti Iyengar, Durisala Desaiah, Hong Liu-Seifert, Vladimir Skljarevski
Publikováno v:
Spine. 35:E578-E585
STUDY DESIGN This was a randomized, double-blind, placebo-controlled clinical trial. OBJECTIVE To assess the efficacy and safety of duloxetine in the treatment of chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA Imbalance of serotonin and nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7257c12e91db35578f8d0546adcb74b
https://doi.org/10.1097/brs.0b013e3181d3cef6
https://doi.org/10.1097/brs.0b013e3181d3cef6
Autor:
Curtis Wiltse, Michael J. Detke, Laurence A. Bradley, Michael Spaeth, Deborah N. D'Souza, Amy S. Chappell
Publikováno v:
International Journal of General Medicine, Vol 2008, Iss default, Pp 91-102 (2008)
International journal of general medicine
International journal of general medicine
Amy S Chappell1, Laurence A Bradley2, Curtis Wiltse1, Michael J Detke1,3,4, Deborah N D’Souza1, Michael Spaeth51Lilly Research Laboratories, Indianapolis, IN, USA; 2University of Alabama at Birmingham, Birmingham, Alabama, USA; 3Indiana University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c054a8057e21a6ad8c7551777043d7c
http://www.dovepress.com/a-six-month-double-blind-placebo-controlled-randomized-clinical-trial--a2689
http://www.dovepress.com/a-six-month-double-blind-placebo-controlled-randomized-clinical-trial--a2689