Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael J Brennick"'
Autor:
Vsevolod Y. Polotsky, Huy Pho, Lenise Jihe Kim, Carla Freire, Jordi Bonaventura, Luiz G.S. Branco, Mateus R. Amorim, Michael Michaelides, Luiz Ubirajara Sennes, Michael J Brennick, Alan R. Schwartz, Rachel Lee, Meaghan E Cabassa, Stone R Streeter, Richard G. Spencer, David D. Fuller, Kenneth Fishbein, Thomaz Fleury Curado
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Obstructive sleep apnea is recurrent upper airway obstruction caused by a loss of upper airway muscle tone during sleep. The main goal of our study was to determine if designer receptors exclusively activated by designer drugs (DREADD) cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd291f4e4c9d871496a2a9d38f0706c
https://doi.org/10.1164/rccm.202002-0321oc
https://doi.org/10.1164/rccm.202002-0321oc
Autor:
Michael J Brennick
Publikováno v:
The Journal of Physiology. 598:431-432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690a6426373015c098031412b6a331b5
https://doi.org/10.1113/jp278970
https://doi.org/10.1113/jp278970
Autor:
Olga Dergacheva, Michael Michaelides, Rachel Lee, Alan Jay Schwartz, Kenneth W. Fishbein, Thomaz Fleury Curado, Michael J Brennick, Lenise Kim, Huy Pho, Jordy Bonaventura, David Mendelowitz, Vsevolod Y. Polotsky
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71ecf1dd0212d7c2ae0505ca9e40f7d
https://doi.org/10.1096/fasebj.2020.34.s1.06437
https://doi.org/10.1096/fasebj.2020.34.s1.06437
Autor:
Kenneth W. Fishbein, Huy Pho, Luiz Ubirajara Sennes, Richard G. Spencer, Luu V. Pham, Olga Dergacheva, Thomaz Fleury Curado, Michael J Brennick, Alan R. Schwartz, Vsevolod Y. Polotsky, David Mendelowitz, Ellen E. Ladenheim
Publikováno v:
Scientific Reports
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce106ee63e918533b49f06ac36b531c
https://doi.org/10.1038/srep44392
https://doi.org/10.1038/srep44392
Autor:
Allan I. Pack, Michael J. Brennick, James Delikatny, Richard Schwab, Jacqueline R. Cater, David Y Kim, Laurence U. Buxbaum, Sarika Shinde, Ivana Roscoe, Stephen Pickup, Jingxu Zhu
Publikováno v:
Sleep. 37:1095-1102
STUDY OBJECTIVES Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat. Our objective was to examine the effects of obesity on upper airway structures in obese (OBZ) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aafe7ef15cf72d84038dd71eddaec9b
https://doi.org/10.5665/sleep.3768
https://doi.org/10.5665/sleep.3768
Publikováno v:
Medical Engineering & Physics. 31:1343-1348
This study presents a new computational system for modeling the upper airway in rats that combines tagged magnetic resonance imaging (MRI) with tissue material properties to predict three-dimensional (3D) airway motion. The model is capable of predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3473e9d41c1bb799bb1d023727d047b
https://doi.org/10.1016/j.medengphy.2009.08.006
https://doi.org/10.1016/j.medengphy.2009.08.006
Autor:
Richard Schwab, Eugene Kim, Kei Ko, Allan I. Pack, Michael J. Brennick, Greg Maislin, Stephen Pickup
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 179:158-169
Rationale: The effect of obesity on upper airway soft tissue structure and size was examined in the New Zealand Obese (NZO) mouse and in a control lean mouse, the New Zealand White (NZW). Objectives: We hypothesized that the NZO mouse has increased v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c94c880ca6f2bd4aa4336b4586cb45d
https://doi.org/10.1164/rccm.200809-1435oc
https://doi.org/10.1164/rccm.200809-1435oc
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 173:1031-1037
Rationale: Although obstructive sleep apnea is strongly associated with obesity, we have little understanding of how obesity may alter the mechanical properties of the pharynx and the role of obesity in the pathogenesis of sleep apnea. Objectives: Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26332fab0c643347f4b71a91e3147b68
https://doi.org/10.1164/rccm.200505-705oc
https://doi.org/10.1164/rccm.200505-705oc
Publikováno v:
The Journal of Physiology. 561:597-610
To better understand pharyngeal airway mechanics as it relates to the pathogenesis and treatment of obstructive sleep apnoea, we have developed a novel application of magnetic resonance imaging (MRI) with non-invasive tissue tagging to measure pharyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c5b18f66909b136f601eac9f7026e35
https://doi.org/10.1113/jphysiol.2004.073502
https://doi.org/10.1113/jphysiol.2004.073502
Autor:
Michael J. Brennick, Samuel T. Kuna
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 166:972-977
Fiberoptic imaging in an isolated, sealed upper airway was performed in 10 decerebrate cats to determine the effect of pharyngeal muscle activation on airway pressure-area relationships. Bilateral cuff electrodes stimulated the distal cut ends of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee55305422af4cd00a6ef486b0d54847
https://doi.org/10.1164/rccm.200203-214oc
https://doi.org/10.1164/rccm.200203-214oc