Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Michael J Blackman"'
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, Enrica Calvani, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011449 (2023)
Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim of identifyi
Externí odkaz:
https://doaj.org/article/729265df578440d2850076d88548b0c4
Autor:
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James Macrae, Lucy Collinson, Tim Wolf Gilberger, Michael J Blackman
Publikováno v:
eLife, Vol 11 (2022)
The malaria parasite Plasmodium falciparum synthesizes significant amounts of phospholipids to meet the demands of replication within red blood cells. De novo phosphatidylcholine (PC) biosynthesis via the Kennedy pathway is essential, requiring choli
Externí odkaz:
https://doaj.org/article/3dc6ce734f2e4ee29e67558c5b100ae5
Autor:
Christine R Collins, Fiona Hackett, Steven A Howell, Ambrosius P Snijders, Matthew RG Russell, Lucy M Collinson, Michael J Blackman
Publikováno v:
eLife, Vol 9 (2020)
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane seals and pinches off behind the parasite through an unknown mechanism, enclosing the parasite wit
Externí odkaz:
https://doaj.org/article/db80ffd4e5224938a70dac40b370a90c
Autor:
Emma S Sherling, Abigail J Perrin, Ellen Knuepfer, Matthew R G Russell, Lucy M Collinson, Louis H Miller, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008049 (2019)
The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation. Invasive malaria merozoites possess
Externí odkaz:
https://doaj.org/article/2489d6a65cf34f7da3cb255cdebd8f41
Autor:
Avnish Patel, Abigail J Perrin, Helen R Flynn, Claudine Bisson, Chrislaine Withers-Martinez, Moritz Treeck, Christian Flueck, Giuseppe Nicastro, Stephen R Martin, Andres Ramos, Tim W Gilberger, Ambrosius P Snijders, Michael J Blackman, David A Baker
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000264 (2019)
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disr
Externí odkaz:
https://doaj.org/article/2be28e1039ea4a58a0e34dc0e05e7111
Autor:
Christian Flueck, Laura G Drought, Andrew Jones, Avnish Patel, Abigail J Perrin, Eloise M Walker, Stephanie D Nofal, Ambrosius P Snijders, Michael J Blackman, David A Baker
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000154 (2019)
Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechanisms by which cyclic AMP (cAMP) is regulated remain en
Externí odkaz:
https://doaj.org/article/f2dfa91a00fe4670be575d3637a30657
Autor:
Lou S Herman, Kimberly Fornace, Jody Phelan, Matthew J Grigg, Nicholas M Anstey, Timothy William, Robert W Moon, Michael J Blackman, Chris J Drakeley, Kevin K A Tetteh
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 6, p e0006457 (2018)
BACKGROUND:Plasmodium knowlesi is the most common cause of malaria in Malaysian Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data on the true extent of transmission. Serological estimations of transmissi
Externí odkaz:
https://doaj.org/article/d0d437d3cd18438aaac3016b08e432fc
Autor:
Nonlawat Boonyalai, Christine R Collins, Fiona Hackett, Chrislaine Withers-Martinez, Michael J Blackman
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207621 (2018)
The malaria parasite replicates within erythrocytes. The pathogenesis of clinical malaria is in large part due to the capacity of the parasite to remodel its host cell. To do this, intraerythrocytic stages of Plasmodium falciparum export more than 30
Externí odkaz:
https://doaj.org/article/71073641c50e44cda15181490dffd4d3
Autor:
Elena Deligianni, Natalie C Silmon de Monerri, Paul J McMillan, Lucia Bertuccini, Fabiana Superti, Maria Manola, Lefteris Spanos, Christos Louis, Michael J Blackman, Leann Tilley, Inga Siden-Kiamos
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204083 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0201651.].
Externí odkaz:
https://doaj.org/article/54b2168a32f946c1867c4a2b7a36c198