Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Michael J Beckstead"'
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180710 (2017)
Methamphetamine (METH) is a psychostimulant that exhibits significant abuse potential. Although METH addiction is a major health and societal concern, no drug is currently approved for its therapeutic management. METH activates the central dopaminerg
Externí odkaz:
https://doaj.org/article/5e05325dbd8e47e8b7a196fd930b6da7
Autor:
Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108413- (2023)
Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.). While anecdotally reported as problematic, there are no publishe
Externí odkaz:
https://doaj.org/article/efa2f29c8faf4f80b3c9fffa0d593cbf
Autor:
Eva Troyano-Rodriguez, Harris E. Blankenship, Kylie Handa, Sarah Y. Branch, Michael J. Beckstead
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline. In the midbrain, D2-type dopamine receptors located at dendrodend
Externí odkaz:
https://doaj.org/article/3fabb43524e64ee8a7708752402415af
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Jr., Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102550- (2023)
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://doaj.org/article/81eb975c107342e8860817ab0704bc01
Autor:
Patricia Perez-Bonilla, Jariel Ramirez-Virella, Pooja Menon, Eva Troyano-Rodriguez, Sydney K. Arriaga, Anna Makela, Raluca Bugescu, Michael J. Beckstead, Gina M. Leinninger
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Central neurotensin signaling via neurotensin receptor-1 (NtsR1) modulates various aspects of physiology, including suppressing feeding and promoting locomotor activity that can support weight loss. However, it remains unclear when and where NtsR1 ex
Externí odkaz:
https://doaj.org/article/656cb02fd6c94327b9120073c7af0795
Autor:
Christopher W. Tschumi, Harris E. Blankenship, Ramaswamy Sharma, William B. Lynch, Michael J. Beckstead
Publikováno v:
J Neurosci
Midbrain dopamine neurons play central physiological roles in voluntary movement, reward learning, and motivated behavior. Inhibitory signaling at somatodendritic dopamine D2 receptor (D2R) synapses modulates excitability of dopamine neurons. The neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d71ce9b76d2a456605ec18da264a3c
https://doi.org/10.1523/jneurosci.1395-20.2022
https://doi.org/10.1523/jneurosci.1395-20.2022
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8b6ef32190488325af9a79346f5c61f
https://doi.org/10.1124/jpet.122.552490
https://doi.org/10.1124/jpet.122.552490
Autor:
Darius Donohue, Kelsey Carter, Patricia Vangeneugden, Kylie Handa, Sofia Weaver, Amanda L. Sharpe, Michael J. Beckstead
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33013452e2c55f0dd5fdad146c1f60a6
https://doi.org/10.1124/jpet.122.215440
https://doi.org/10.1124/jpet.122.215440
Autor:
Collyn M. Kellogg, Kevin Pham, Adeline H. Machalinski, Hunter L. Porter, Harris E. Blankenship, Michael B. Stout, Heather C. Rice, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
bioRxiv
Major Histocompatibility Complex I (MHC-I) function in the CNS is still being determined after previously being thought to be absent from the brain. MHC-I expression increases with brain aging in mouse, rat, and human whole tissue analyses. Neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a42275d549dfe469c0587a115227cb2
https://doi.org/10.1101/2023.03.07.531435
https://doi.org/10.1101/2023.03.07.531435
Autor:
Shylesh Bhaskaran, Gaurav Kumar, Nidheesh Thadathil, Katarzyna M. Piekarz, Sabira Mohammed, Sergio Dominguez Lopez, Rizwan Qaisar, Dorothy Walton, Jacob L. Brown, Ashley Murphy, Nataliya Smith, Debra Saunders, Michael J. Beckstead, Scott Plafker, Tommy L. Lewis, Rheal Towner, Sathyaseelan S. Deepa, Arlan Richardson, Robert C. Axtell, Holly Van Remmen
Publikováno v:
Redox biology. 59
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase (MnSOD) using a neuron specific Cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28422549922b2ae9379aa3618d8b536
https://pubmed.ncbi.nlm.nih.gov/36470129
https://pubmed.ncbi.nlm.nih.gov/36470129