Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Michael J Ausserlechner"'
Autor:
Judith Hagenbuchner, Veronika Obsilova, Teresa Kaserer, Nora Kaiser, Bettina Rass, Katarina Psenakova, Vojtech Docekal, Miroslava Alblova, Klara Kohoutova, Daniela Schuster, Tatsiana Aneichyk, Jan Vesely, Petra Obexer, Tomas Obsil, Michael J Ausserlechner
Publikováno v:
eLife, Vol 8 (2019)
FOXO transcription factors are critical regulators of cell homeostasis and steer cell death, differentiation and longevity in mammalian cells. By combined pharmacophore-modeling-based in silico and fluorescence polarization-based screening we identif
Externí odkaz:
https://doaj.org/article/2a1679493eee41128e3edfeaf260a091
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 886 (2023)
Mitochondria have been recognized as the energy (in the form of ATP)-producing cell organelles, required for cell viability, survival and normal cell function [...]
Externí odkaz:
https://doaj.org/article/54c1a12254fa498387a7685f596844ec
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1995 (2022)
Besides their main function for energy production in form of ATP in processes of oxidative phosphorylation (OxPhos), mitochondria perform many other important cellular functions and participate in various physiological processes that are congregated.
Externí odkaz:
https://doaj.org/article/21ca38e5741f4084b769740537985fe4
Autor:
Andrey V. Kuznetsov, Sabzali Javadov, Raimund Margreiter, Judith Hagenbuchner, Michael J. Ausserlechner
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2252 (2022)
Analysis of the function, structure, and intracellular organization of mitochondria is important for elucidating energy metabolism and intracellular energy transfer. In addition, basic and clinically oriented studies that investigate organ/tissue/cel
Externí odkaz:
https://doaj.org/article/845ac47aa0554696a4be44d7645b6f09
Autor:
Klara Kohoutova, Vojtěch Dočekal, Michael J. Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner, Tomas Obsil
Publikováno v:
ACS Omega. 7:34632-34646
Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Accordingly, FOXO3 inhibition is a promising strategy for boosting antitumor immune responses and suppressing FOXO3-mediated therapy resistance
Autor:
Khaled I. Alatibi, Stefan Tholen, Zeinab Wehbe, Judith Hagenbuchner, Daniela Karall, Michael J. Ausserlechner, Oliver Schilling, Sarah C. Grünert, Jerry Vockley, Sara Tucci
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10556 (2021)
Medium-chain fatty acids (mc-FAs) are currently applied in the treatment of long-chain fatty acid oxidation disorders (lc-FAOD) characterized by impaired β-oxidation. Here, we performed lipidomic and proteomic analysis in fibroblasts from patients w
Externí odkaz:
https://doaj.org/article/562b87a8ed954c32bbae0c74300f6766
Autor:
Khaled I. Alatibi, Judith Hagenbuchner, Zeinab Wehbe, Daniela Karall, Michael J. Ausserlechner, Jerry Vockley, Ute Spiekerkoetter, Sarah C. Grünert, Sara Tucci
Publikováno v:
Cells, Vol 10, Iss 5, p 1239 (2021)
Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in
Externí odkaz:
https://doaj.org/article/092f3c8e3b6a42ba93a9c56672d96667
Publikováno v:
Essays in Biochemistry
Conventional approaches in drug development involve testing on 2D-cultured mammalian cells, followed by experiments in rodents. Although this is the common strategy, it has significant drawbacks: in 2D cell culture with human cells, the cultivation a
FOXO transcription factors are critical regulators of cell homeostasis that control a plethora of different target genes and thereby steer cell death, differentiation, longevity and senescence in mammalian cells. The objective of the present study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ad60bd7ae8157a43abdbf6a71d35d9
https://doi.org/10.9734/bpi/nicb/v4/14349d
https://doi.org/10.9734/bpi/nicb/v4/14349d
Autor:
H Fiegl, Judith Hagenbuchner, AG Zeimet, I Tsibulak, Michael J. Ausserlechner, J Kögl, C Marth
Publikováno v:
Ovarian cancer.