Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Michael J, Spinella"'
Autor:
Doha Shokry, Mehwish W. Khan, Christine Powell, Samantha Johnson, Brayden C. Rennels, Raya I. Boyd, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Maryanna H. Parker, Miranda D. Vieson, Jonathan P. Samuelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist. Curative cisplatin the
Externí odkaz:
https://doaj.org/article/68755ecf9402453293b42c650e2ab10c
Autor:
Andrea K. Corbet, Emmanuel Bikorimana, Raya I. Boyd, Doha Shokry, Kelly Kries, Ayush Gupta, Anneliese Paton, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Erik R. Nelson, Michael J. Spinella, Ratnakar Singh
Publikováno v:
Translational Oncology, Vol 33, Iss , Pp 101676- (2023)
G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell proliferation,
Externí odkaz:
https://doaj.org/article/cbcbc9b7c9dc4ba880141b3cdbbac673
Autor:
Raya I. Boyd, Doha Shokry, Zeeshan Fazal, Brayden C. Rennels, Sarah J. Freemantle, Michael R. La Frano, Gail S. Prins, Zeynep Madak Erdogan, Joseph Irudayaraj, Ratnakar Singh, Michael J. Spinella
Publikováno v:
Toxics, Vol 12, Iss 4, p 232 (2024)
The potential effects of poly- and perfluoroalkyl substances (PFAS) are a recently emergent human and environmental health concern. There is a consistent link between PFAS exposure and cancer, but the mechanisms are poorly understood. Although epidem
Externí odkaz:
https://doaj.org/article/63bec03f1c444472b4882a8ed84927b2
Autor:
Ratnakar Singh, Zeeshan Fazal, Emmanuel Bikorimana, Raya I. Boyd, Cliff Yerby, Megan Tomlin, Hannah Baldwin, Doha Shokry, Andrea K. Corbet, Khadeeja Shahid, Aleyah Hattab, Sarah J. Freemantle, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
Autor:
Zeeshan Fazal, Ratnakar Singh, Fang Fang, Emmanuel Bikorimana, Hannah Baldwin, Andrea Corbet, Megan Tomlin, Cliff Yerby, Nabil Adra, Costantine Albany, Sarah Lee, Sarah J. Freemantle, Kenneth P Nephew, Brock C Christensen, Michael J. Spinella
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1071-1084 (2021)
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, altho
Externí odkaz:
https://doaj.org/article/4b7b7223caa54e218dd20f2ec7342e9a
Publikováno v:
Toxics, Vol 11, Iss 1, p 32 (2022)
Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important or
Externí odkaz:
https://doaj.org/article/22a7c4db8e524a4a890d2fb3c4c29575
Autor:
Sarah J. Freemantle, Megan Tomlin, Khadeeja Shahid, Andrea K. Corbet, Aleyah Hattab, Emmanuel Bikorimana, Hannah Baldwin, Raya I. Boyd, Ratnakar Singh, Cliff Yerby, Doha Shokry, Zeeshan Fazal, Michael J. Spinella
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 683-698 (2022)
Molecular Oncology
Molecular Oncology
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ddf3799002302ee27479edca374322
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
https://doaj.org/article/1996a69b2850475d84e180ad54ed68ef
Autor:
Michael J. Spinella, Ethan Dmitrovsky, Alan Eastman, Sarah J. Freemantle, Mary P. Hever, Kristen M. Garner, Maroun J. Beyrouthy
Testicular germ cell tumors (TGCT) are the most common solid tumors of 15- to 35-year-old men. TGCT patients are frequently cured with cytotoxic cisplatin-based therapy. However, TGCT patients refractory to cisplatin-based chemotherapy have a poor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbb8d89ae38c819ad7a39463250a181
https://doi.org/10.1158/0008-5472.c.6500375
https://doi.org/10.1158/0008-5472.c.6500375
Autor:
Michael J. Spinella, Ethan Dmitrovsky, Alan Eastman, Sarah J. Freemantle, Mary P. Hever, Kristen M. Garner, Maroun J. Beyrouthy
Supplementary Table 1 from High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf2a4bfb16b7eb11b4b15b752b97fbb
https://doi.org/10.1158/0008-5472.22382969
https://doi.org/10.1158/0008-5472.22382969
Autor:
Michael J. Spinella, Ethan Dmitrovsky, Sarah J. Freemantle, Janice Tam, Joshua M. Warzecha, Xi Liu, Mary P. Hever-Jardine, David J. Sekula, Christina Y. Yim
Inivariant Cox proportional analysis for replace/recurrence free survival in breast cancer with high G0S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3776faf2df5018cd21caea8dc32d374d
https://doi.org/10.1158/0008-5472.22409067
https://doi.org/10.1158/0008-5472.22409067