Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Michael J, Shattock"'
Autor:
Yu Jin Chung, Zoe Hoare, Friedrich Baark, Chak Shun Yu, Jia Guo, William Fuller, Richard Southworth, Doerthe M. Katschinski, Michael P. Murphy, Thomas R. Eykyn, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Elevated intracellular sodium Nai adversely affects mitochondrial metabolism and is a common feature of heart failure. The reversibility of acute Na induced metabolic changes is evaluated in Langendorff perfused rat hearts using the Na/K ATP
Externí odkaz:
https://doaj.org/article/8ac1f41d178b4502b68cf04de0eb6baa
Autor:
Aidan M. Michaels, Anna Zoccarato, Zoe Hoare, George Firth, Yu Jin Chung, Philip W. Kuchel, Ajay M. Shah, Michael J. Shattock, Richard Southworth, Thomas R. Eykyn
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Glycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased demand for adenosine triphosphate (ATP), however it is unknown what this extra ATP turnover
Externí odkaz:
https://doaj.org/article/61fe531d26c740f2a46c9ccc1181bfa7
Autor:
Jacqueline Howie, Lindsay B. Tulloch, Elaine Brown, Louise Reilly, Fiona B. Ashford, Jennifer Kennedy, Krzysztof J. Wypijewski, Karen L. Aughton, Jason K.C. Mak, Michael J. Shattock, Niall J. Fraser, William Fuller
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113679- (2024)
Summary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoy
Externí odkaz:
https://doaj.org/article/dcac5956dc204ac4934750eee8fdf86f
Autor:
Mingjie Bai, Emily Gallen, Sarah Memarzadeh, Jacqueline Howie, Xing Gao, Chien-Wen S Kuo, Elaine Brown, Simon Swingler, Sam J Wilson, Michael J Shattock, David J France, William Fuller
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299665 (2024)
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral me
Externí odkaz:
https://doaj.org/article/4fde80e1212443ac90281f207fa24630
Autor:
Andrew R. Hall, Qutuba G. Karwi, Sanjeev Kumar, Rachel Dongworth, Dunja Aksentijević, Tariq R. Altamimi, Kevin Timothy Fridianto, Kroekkiat Chinda, Sauri Hernandez-Resendiz, Mohammad U. Mahmood, Evangelos Michelakis, Chrishan J. Ramachandra, Jianhong Ching, Jose M. Vicencio, Michael J. Shattock, Jean-Paul Kovalik, Derek M. Yellon, Gary Lopaschuk, Derek J. Hausenloy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD+-dependent deacetylase, Sirtuin-3 (SIRT3), which has been shown to
Externí odkaz:
https://doaj.org/article/3a9998b09ea84a4bb20bc74a3baad146
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background T-type calcium channels (TTCC) are low voltage activated channels that are widely expressed in the heart, smooth muscle and neurons. They are known to impact on cell cycle progression in cancer and smooth muscle cells and more rec
Externí odkaz:
https://doaj.org/article/c024ae6a365145099904a2b946badbc3
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprogra
Externí odkaz:
https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-se
Externí odkaz:
https://doaj.org/article/6fbf0e80815742af83dc671f7e0123a4
Autor:
Caroline Mendonca Costa, Grace C. Anderson, Veronique M. F. Meijborg, Christopher O’Shea, Michael J. Shattock, Paulus Kirchhof, Ruben Coronel, Steven Niederer, Davor Pavlovic, Tarvinder Dhanjal, James Winter
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundRe-entrant ventricular tachycardia may be non-inducible or haemodynamically compromising, requiring assessment of the electrophysiological properties of the myocardium during sinus rhythm (i.e., substrate mapping). Areas of heart tissue wit
Externí odkaz:
https://doaj.org/article/6f338b038323451ab5d43600d2f00442