Zobrazeno 1 - 10
of 537
pro vyhledávání: '"Michael J, Rogers"'
Autor:
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly under
Externí odkaz:
https://doaj.org/article/21b5b88799f3482d9c5c720c2d6c2ea8
Autor:
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers
Publikováno v:
eLife, Vol 10 (2021)
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to r
Externí odkaz:
https://doaj.org/article/efd2366c282f45e0a4b6b5d87db2968d
Publikováno v:
American Journal of Biological Anthropology. 181:206-215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0feb58ed08c9a1b717e83dd9cbc0d3ff
https://doi.org/10.1002/ajpa.24717
https://doi.org/10.1002/ajpa.24717
Autor:
Marcia A. Munoz, Julie Jurczyluk, Anna Simon, Pravin Hissaria, Rob J. W. Arts, David Coman, Christina Boros, Sam Mehr, Michael J. Rogers
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase. Deficiency of this enzyme decreases the synthesis
Externí odkaz:
https://doaj.org/article/27842b62c9b644a9a479322c9f12f919
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf662da78ed20d5cf712db233a51417
https://doi.org/10.1158/2159-8290.22530387
https://doi.org/10.1158/2159-8290.22530387
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in 4T1 breast tumour.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f217b10600e0c556fba992180f86e9df
https://doi.org/10.1158/2159-8290.22530384.v1
https://doi.org/10.1158/2159-8290.22530384.v1
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Supplementary Figure S1. Fluorescently-labelled bisphosphonate is present in the macrophage-rich region of 4T1 mammary tumours in vivo. Supplementary Figure S2. N-BP colocalises with microcalcifications, detected by calcein labelling in 4T1 mammary t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea65363343626e12a65ac8a89ee1cc9
https://doi.org/10.1158/2159-8290.22530390.v1
https://doi.org/10.1158/2159-8290.22530390.v1
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in normal breast tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2e44bee539cb34a25591f6bc40d47
https://doi.org/10.1158/2159-8290.22530381
https://doi.org/10.1158/2159-8290.22530381
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
3D reconstruction of 4T1 mammary tumour 24 hours after injection of bisphosphonate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b6dd46a0a0ddd480f45ce4f18af456
https://doi.org/10.1158/2159-8290.22530372.v1
https://doi.org/10.1158/2159-8290.22530372.v1
Autor:
Michael J. Rogers, Tri Giang Phan, Katherine Weilbaecher, Alexander Swarbrick, Peter I. Croucher, Charles E. McKenna, Boris Kashemirov, Shuting Sun, Akira Nguyen, Andrew Parker, Nicholas Pocock, Jenny Down, Naveid Ali, Julie Jurczyluk, Gemma Shay, Simon Junankar
Real-time intravital two-photon microscopy showing phagocytosis of a large, granular clump of bisphosphonate by a single tumour-associated macrophage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c61b1568a2364c2b9fe9a45fa719c04
https://doi.org/10.1158/2159-8290.22530375
https://doi.org/10.1158/2159-8290.22530375