Zobrazeno 1 - 10
of 654
pro vyhledávání: '"Michael J, Overman"'
Autor:
Sara Lonardi, Eric Van Cutsem, Pilar Garcia-Alfonso, Mark Wong, Fabio Gelsomino, Bassel El-rayes, Michael J Overman, Andrew G Hill, Ming Lei, Massimo Aglietta, Maria Luisa Limon Miron, Gregory Leonard, Antonio Cubillo Gracian, Stephen M McCraith, Beilei He
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Programmed death-1 (PD-1) inhibitors, including nivolumab, have demonstrated long-term survival benefit in previously treated patients with microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer
Externí odkaz:
https://doaj.org/article/8837ecde8e2f4b09ba632cfba21417dd
Autor:
Chantale Bernatchez, Shubham Pant, Rodabe Amaria, Marie-Andree Forget, Milind Javle, Donastas Sakellariou-Thompson, Karen H Lu, Scott Kopetz, Mara B Antonoff, Cara L Haymaker, Ying Yuan, Robert A Wolff, Michael J Overman, Anne Knisely, Amir A Jazaeri, Bryan Fellman, Kelly Rangel, David Vining, Ching-Wei D Tzeng, Kathryn Lito
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background Tumor-infiltrating lymphocyte (TIL) therapy has shown efficacy in metastatic melanoma, non-small cell lung cancer, and other solid tumors. Our preclinical work demonstrated more robust CD8 predominant TIL production when agonistic anti-4-1
Externí odkaz:
https://doaj.org/article/9db26df43372455eb057f56b039dcefa
Autor:
Fadl A. Zeineddine, Mohammad A. Zeineddine, Abdelrahman Yousef, Yue Gu, Saikat Chowdhury, Arvind Dasari, Ryan W. Huey, Benny Johnson, Bryan Kee, Michael S. Lee, Maria Pia Morelli, Van K. Morris, Michael J. Overman, Christine Parseghian, Kanwal Raghav, Jason Willis, Robert A. Wolff, Yoshikuni Kawaguchi, Jean-Nicolas Vauthey, Ryan Sun, Scott Kopetz, John Paul Shen
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)
Abstract Over the past two decades of successive clinical trials in metastatic colorectal cancer (CRC), the median overall survival of both control and experimental arms has steadily improved. However, the incremental change in survival for metastati
Externí odkaz:
https://doaj.org/article/7b9f437bc4574113bf04a302f7650255
Autor:
Alexander F. Bagley, Ethan B. Ludmir, Anirban Maitra, Bruce D. Minsky, Grace Li Smith, Prajnan Das, Albert C. Koong, Emma B. Holliday, Cullen M. Taniguchi, Matthew H.G. Katz, Eric P. Tamm, Robert A. Wolff, Michael J. Overman, Shivani Patel, Michael P. Kim, Ching-Wei D. Tzeng, Naruhiko Ikoma, Manoop S. Bhutani, Eugene J. Koay
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 33, Iss , Pp 66-69 (2022)
Background and purpose: Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading causes of cancer-related deaths in the world. For patients with PDAC who are not eligible for surgery, radiation therapy improves local disease control, yet sa
Externí odkaz:
https://doaj.org/article/928b9cb96de949b2aa06a4d2d39c4f62
Autor:
Chiara Cremolini, Francesca Corti, Elisabetta Fenocchio, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Giacomo Mazzoli, Francesco Barretta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Immune checkpoint inhibitors (ICIs) show a tremendous activity in microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC), but a consistent fraction of patients does not respond. Prognostic/predictive markers are needed
Externí odkaz:
https://doaj.org/article/7d567d1042404b5e91439f87cbff2736
Autor:
Deepak Bhamidipati, Anuj Verma, Dawen Sui, Dipen Maru, Grace Mathew, Wenhua Lang, Juan Posadas, Joshua Hein, Scott Kopetz, Andrew Futreal, Ignacio I. Wistuba, Sanjay Gupta, J. Jack Lee, Michael J. Overman, Alda L. Tam
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract Factors correlated with biopsy tissue adequacy and the prevalence of within-biopsy variability were evaluated. Totally, 1149 research biopsies were performed on 686 patients from which 5090 cores were assessed. Biopsy cores were reviewed for
Externí odkaz:
https://doaj.org/article/04b5f9e59ae04d2c80e5e8c4937a09ec
Autor:
Chirayu Mohindroo, Merve Hasanov, Jane E. Rogers, Wenli Dong, Laura R. Prakash, Seyda Baydogan, Jonathan D. Mizrahi, Michael J. Overman, Gauri R. Varadhachary, Robert A. Wolff, Milind M. Javle, David R. Fogelman, Michael T. Lotze, Michael P. Kim, Matthew H.G. Katz, Shubham Pant, Ching‐Wei D. Tzeng, Florencia McAllister
Publikováno v:
Cancer Medicine, Vol 10, Iss 15, Pp 5041-5050 (2021)
Abstract Recent studies defined a potentially important role of the microbiome in modulating pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized that antibiotic usage may predict outcomes in patients with PDAC. We retr
Externí odkaz:
https://doaj.org/article/0a9f7dec3b6a427caf5cf0242b007a10
Autor:
Preeti Kanikarla Marie, Alexey V. Sorokin, Lea A. Bitner, Rebecca Aden, Michael Lam, Ganiraju Manyam, Melanie N. Woods, Amanda Anderson, Anna Capasso, Natalie Fowlkes, Michael J. Overman, David G. Menter, Scott Kopetz
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Designing studies of immunotherapy is limited due to a lack of pre-clinical models that reliably predict effective immunotherapy responses. To address this gap, we developed humanized mouse models of colorectal cancer (CRC) incorporating patient-deri
Externí odkaz:
https://doaj.org/article/ec06ee797f544d198959a8dcc024cd38
Autor:
Ignacio I Wistuba, Andrew Futreal, Xuemei Wang, Arvind Dasari, Cathy Eng, Scott Kopetz, Edwin R Parra, Cara L Haymaker, Eduardo Vilar, Robert A Wolff, Kanwal Raghav, Michael J Overman, Younghee Lee, Benny Johnson, Luisa Maren Solis Soto, Jane V Thomas, Van K Morris, Bryan K Kee, Christine M Parseghian, Daniele Lorenzini, Caddie Laberiano-Fernandez, Anuj Verma, Wenhua Lang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background Monotherapy with immune checkpoint blockade is ineffective for patients (pts) with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). This study investigates whether the combination of trametinib (T) with durvalumab (D) can a
Externí odkaz:
https://doaj.org/article/df046ec2d0ff48c99275fc303b6ac56b
Autor:
Sanjay Shete, Christopher J Miller, Michael J Overman, Anaeze C Offodile, Sandra R DiBrito, Janice P Finder, Sanchita Jain, Domenica A Delgado, Elenita Davidson, Susan K Peterson
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Remote patient monitoring (RPM) has emerged as a potential avenue for optimising the management of symptoms in patients undergoing chemotherapy. However, RPM is a complex, multilevel intervention with technology, workflow, contextual and
Externí odkaz:
https://doaj.org/article/0168f70974444144a0aa48a672cfaf33