Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael J, O Wakelam"'
Autor:
Harald C. Köfeler, Thomas O. Eichmann, Robert Ahrends, John A. Bowden, Niklas Danne-Rasche, Edward A. Dennis, Maria Fedorova, William J. Griffiths, Xianlin Han, Jürgen Hartler, Michal Holčapek, Robert Jirásko, Jeremy P. Koelmel, Christer S. Ejsing, Gerhard Liebisch, Zhixu Ni, Valerie B. O’Donnell, Oswald Quehenberger, Dominik Schwudke, Andrej Shevchenko, Michael J. O. Wakelam, Markus R. Wenk, Denise Wolrab, Kim Ekroos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/83316378728a498088000222c0fb33af
Autor:
Claudia Di Carlo, Bebiana C. Sousa, Marcello Manfredi, Jessica Brandi, Elisa Dalla Pozza, Emilio Marengo, Marta Palmieri, Ilaria Dando, Michael J. O. Wakelam, Andrea F. Lopez-Clavijo, Daniela Cecconi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common p
Externí odkaz:
https://doaj.org/article/7ecf05d9ceac409bb21256e8799d63d9
Autor:
Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F. Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C. Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W. Wingett, Hermine Kienberger, Karin Kleigrewe, Mario de Bono, Michael J. O. Wakelam, Olivia Casanueva
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock fa
Externí odkaz:
https://doaj.org/article/a78b7a74d13c459bbb5c8c7072758ce4
Autor:
Rafael M. Kochaj, Elisa Martelletti, Neil J. Ingham, Annalisa Buniello, Bebiana C. Sousa, Michael J. O. Wakelam, Andrea F. Lopez-Clavijo, Karen P. Steel
Publikováno v:
Cells, Vol 11, Iss 20, p 3206 (2022)
Peroxisome biogenesis disorders (due to PEX gene mutations) are associated with symptoms that range in severity and can lead to early childhood death, but a common feature is hearing impairment. In this study, mice carrying Pex3 mutations were found
Externí odkaz:
https://doaj.org/article/0d73c06f900a4e4abd15f4704ece98dc
Autor:
Jenika D Marshall, Emily R Courage, Ryan F Elliott, Madeline N Fitzpatrick, Anne D Kim, Andrea F Lopez-Clavijo, Bronwyn A Woolfrey, Mireille Ouimet, Michael J O Wakelam, Robert J Brown
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233180 (2020)
Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and it may promote the progression of atherosclerosis, but the mechanisms behind this process are not completely understood. We previously showed that the phosphorylation of Akt withi
Externí odkaz:
https://doaj.org/article/12e6f68f56114505aedddcafff9f7287
Autor:
Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J. Joshi, Jake P. N. Hattwell, Paul R. Ebert, Michel van Weeghel, Arwen W. Gao, Michael J. O. Wakelam, Riekelt H. Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E. Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena. Despite having been in the focus of research for c
Externí odkaz:
https://doaj.org/article/ba4e5b226b894e14acb1ce2a596c70c2
Autor:
null Bebiana C. Sousa, null Zulema Gonzalez Klein, null Diane Taylor, null Greg West, null Aveline Neo Huipeng, null Michael J. O. Wakelam, null Andrea F. Lopez‐Clavijo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57dbb052e5a5fc7e396d010679015df6
https://doi.org/10.1002/rcm.9472/v2/response1
https://doi.org/10.1002/rcm.9472/v2/response1
Autor:
Matthieu M Vermeren, Qifeng Zhang, Elizabeth Smethurst, Anne Segonds-Pichon, Heinrich Schrewe, Michael J O Wakelam
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162814 (2016)
Phospholipase D2 (PLD2) is an enzyme that produces phosphatidic acid (PA), a lipid messenger molecule involved in a number of cellular events including, through its membrane curvature properties, endocytosis. The PLD2 knock out (PLD2KO) mouse has bee
Externí odkaz:
https://doaj.org/article/08c6d72cd8164d30b2a4638761b5cd4a
Publikováno v:
Open Biology, Vol 5, Iss 9 (2015)
We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) hom
Externí odkaz:
https://doaj.org/article/bed6b15199054c1995463a69147f90c6
Autor:
Edgar Morales-Rios, Ian N. Watt, Qifeng Zhang, Shujing Ding, Ian M. Fearnley, Martin G. Montgomery, Michael J. O. Wakelam, John E. Walker
Publikováno v:
Open Biology, Vol 5, Iss 9 (2015)
The structures of F-ATPases have been determined predominantly with mitochondrial enzymes, but hitherto no F-ATPase has been crystallized intact. A high-resolution model of the bovine enzyme built up from separate sub-structures determined by X-ray c
Externí odkaz:
https://doaj.org/article/8d07d2071bff4f70952556789d5b0398