Výsledky vyhledávání - "Michael J, O'Dwyer"

Akademický článek

Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery.

Autor: Hew D T Torrance, E Rebecca Longbottom, Mark E Vivian, Bagrat Lalabekyan, Tom E F Abbott, Gareth L Ackland, Charles J Hinds, Rupert M Pearse, Michael J O'Dwyer

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203795 (2018)

INTRODUCTION:Post-operative infections occur frequently following major surgery. The magnitude of the post-operative immune response is associated with an increased risk of post-operative infections, although the mechanisms driving post-operative imm

Externí odkaz: https://doaj.org/article/cf5ed9c9670446318adc66deae2e70c9

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MicroRNAs in Acute Kidney Injury

Autor: Timothy F. Jones, Soliana Bekele, John R. Prowle, Michael J. O’Dwyer

Publikováno v: Nephron. 140:124-128

Background: It is increasingly recognised that improved diagnosis, prognosis and treatment of acute kidney injury (AKI) requires an understanding of distinct underling cellular and molecular mechanisms (endotypes) that may distinguish overtly similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a37f2af32241f7b5a39a2705882e5d3
https://doi.org/10.1159/000490204

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Does major surgery induce immune suppression and increase the risk of postoperative infection?

Autor: Rupert M Pearse, Hew D.T. Torrance, Michael J. O’Dwyer

Publikováno v: Current Opinion in Anaesthesiology. 29:376-383

Infection is the commonest cause of a postoperative complication. Following major surgery alterations in immune function are commonplace and these may contribute to an enhanced susceptibility to acquire nosocomial infections. This review will discuss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c60b5400ef8783772b4d8b86ff1e05
https://doi.org/10.1097/aco.0000000000000331

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Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5

Autor: Andrew J. Stagg, R. Lahiri, Michael J. O’Dwyer, Edward M. Giles, Hew D.T. Torrance, Alastair O’Brien, Satyajit Bhattacharya, Zora Bashir, William Alazawi, Graham R. Foster, Yannick Derwa, Helen C. Owen

Publikováno v: Annals of Surgery. 263:1028-1037

OBJECTIVES\ud \ud To study innate immune pathways in patients undergoing hepatopancreaticobiliary surgery to understand mechanisms leading to enhanced inflammatory responses and identifying biomarkers of adverse clinical consequences.\ud \ud BACKGROU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6586db4450ac9bed45c98e3c75fc74d1
https://doi.org/10.1097/sla.0000000000001248

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Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model

Autor: Hew D.T. Torrance, Russell Hewson, Shih Pin Lin, Christopher J. Kirwan, John R. Prowle, Rupert M Pearse, Parjam Zolfaghari, Karim Brohi, Michael J. O’Dwyer, Ryan W Haines, Anita West

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports

Acute Kidney Injury (AKI) complicating major trauma is associated with increased mortality and morbidity. Traumatic AKI has specific risk factors and predictable time-course facilitating diagnostic modelling. In a single centre, retrospective observa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688ebf64cae54b3bde86225da2af4b4a
https://doi.org/10.1038/s41598-018-21929-2

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Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma

Autor: Karim Brohi, Timothy F. Jones, Michael J. O’Dwyer, Charles J. Hinds, Rupert M Pearse, Hew D.T. Torrance, Helen C. Owen

Publikováno v: Journal of Trauma and Acute Care Surgery. 79:766-772

BACKGROUND\ud \ud Posttraumatic nosocomial pneumonia is a common complication resulting in significant morbidity. Trauma-induced immunocompromise is associated with an enhanced susceptibility to pneumonia. In this study, we explore the hypothesis tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715b55cb1a6cdc909eb7c562828f969b
https://doi.org/10.1097/ta.0000000000000850

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The research agenda for trauma critical care

Publikováno v: Intensive care medicine, 43(9), 1340-1351. Springer Verlag

In this research agenda on the acute and critical care management of trauma patients, we concentrate on the major factors leading to death, namely haemorrhage and traumatic brain injury (TBI). In haemostasis biology, the results of randomised control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4b381c1c2498db3d30294b816e8fb0
http://hdl.handle.net/11567/945137

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The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study

Autor: J-L Vincent, Martin Wilks, N Libert, David J. Ecker, Kai Zacharowski, Mervyn Singer, David Brealey, M H Starczewska, Jacques Schrenzel, Michael J. O’Dwyer, Ranga Sampath

Publikováno v: Clinical Microbiology and Infection, Vol. 23, No 3 (2017) pp. 208.e1-208.e6

Objectives Blood culture results inadequately stratify the mortality risk in critically ill patients with sepsis. We sought to establish the prognostic significance of the presence of microbial DNA in the bloodstream of patients hospitalized with sus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c13204480ddf6701a3f224069f400da
https://pubmed.ncbi.nlm.nih.gov/27890455

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