Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael J, Munson"'
Autor:
Alena Ivanova, Lukas Badertscher, Gwen O'Driscoll, Joakim Bergman, Euan Gordon, Anders Gunnarsson, Camilla Johansson, Michael J. Munson, Cristiana Spinelli, Sara Torstensson, Liisa Vilén, Andrei Voirel, John Wiseman, Janusz Rak, Niek Dekker, Elisa Lázaro‐Ibáñez
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the repurposing of extracellular vesicles (EVs) as drug delivery vehicles are explored. Target
Externí odkaz:
https://doaj.org/article/e1d689279e454812aab0d9be5d04dcd4
Autor:
Matthew Yoke Wui Ng, Chara Charsou, Ana Lapao, Sakshi Singh, Laura Trachsel-Moncho, Sebastian W. Schultz, Sigve Nakken, Michael J. Munson, Anne Simonsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeo
Externí odkaz:
https://doaj.org/article/e7fede4d4b1c4ef589afdf61c6e3f288
Autor:
Jeremy P. Bost, Miina Ojansivu, Michael J. Munson, Emelie Wesén, Audrey Gallud, Dhanu Gupta, Oskar Gustafsson, Osama Saher, Julia Rädler, Stuart G. Higgins, Taavi Lehto, Margaret N. Holme, Anders Dahlén, Ola Engkvist, Per-Erik Strömstedt, Shalini Andersson, C. I. Edvard Smith, Molly M. Stevens, Elin K. Esbjörner, Anna Collén, Samir El Andaloussi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Two new endosomolytic small compounds increase delivery of splice-switching oligonucleotides by interfering with their trafficking to the LAMP1-positive endosomal compartments, inducing endosomal membrane rupture and concurrent oligonucleotide escape
Externí odkaz:
https://doaj.org/article/bc4472827f7c41fd906f49a090bf9ac9
Autor:
Michael J. Munson, Benan J. Mathai, Matthew Yoke Wui Ng, Laura Trachsel-Moncho, Laura R. de la Ballina, Sebastian W. Schultz, Yahyah Aman, Alf H. Lystad, Sakshi Singh, Sachin Singh, Jørgen Wesche, Evandro F. Fang, Anne Simonsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
The mechanisms involved in programmed or damage-induced removal of mitochondria by mitophagy remain elusive. Here the authors use an siRNA library to screen lipid-binding proteins, and identify the kinases GAK and PRKCD as positive regulators of PRKN
Externí odkaz:
https://doaj.org/article/b12ee5952fc74880a26b3fbe78bc34b0
Autor:
Michael J. Munson, Gwen O’Driscoll, Andreia M. Silva, Elisa Lázaro-Ibáñez, Audrey Gallud, John T. Wilson, Anna Collén, Elin K. Esbjörner, Alan Sabirsh
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Munson et al. develop a high-throughput Galectin-9 reporter based endosomal escape imaging assay to probe correlations between nanoparticle-mediated uptake, endosomal escape frequency, and mRNA translation. By screening various delivery systems, modu
Externí odkaz:
https://doaj.org/article/6d71f1a55da4454e8e456d8390871e01
Autor:
Fanny Joubert, Michael J. Munson, Alan Sabirsh, Richard M. England, Martin Hemmerling, Cameron Alexander, Marianne B. Ashford
Publikováno v:
Journal of Controlled Release. 356:580-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b8d8dadc5c5b44bdfca8abac2ea44b1
https://doi.org/10.1016/j.jconrel.2023.03.011
https://doi.org/10.1016/j.jconrel.2023.03.011
Autor:
Christian R. Palmer, Venkata R. Krishnamurthy, David Ulkoski, Alan Sabirsh, John T. Wilson, Max E. Jacobson, Michael J. Munson, Carcia S. Carson
Publikováno v:
ACS Applied Bio Materials. 4:1640-1654
In recent years, there has been an increasing interest in designing delivery systems to enhance the efficacy of RNA-based therapeutics. Here, we have synthesized copolymers comprised of dimethylaminoethyl methacrylate (DMAEMA) or diethylaminoethyl me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547604e4c2332e6fcbd162480c854490
https://doi.org/10.1021/acsabm.0c01463
https://doi.org/10.1021/acsabm.0c01463
Autor:
Michael J. Munson, Benan J. Mathai, Matthew Yoke Wui Ng, Laura Trachsel-Moncho, Laura R. de la Ballina, Anne Simonsen
Publikováno v:
Autophagy. 18(2)
The removal of mitochondria in a programmed or stress-induced manner is essential for maintaining cellular homeostasis. To date, much research has focused upon stress-induced mitophagy that is largely regulated by the E3 ligase PRKN, with limited ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343fdd706daf04190dd098ebe7e933a8
https://pubmed.ncbi.nlm.nih.gov/35001811
https://pubmed.ncbi.nlm.nih.gov/35001811
Autor:
James Doutch, Elin K. Esbjörner, L. Evenäs, Michael J. Munson, Alan Sabirsh, Margaret N. Holme, Fredrik Höök, K. Liu, Molly M. Stevens, S. R. Tabaei, A. Collén, Audrey Gallud, Lennart Lindfors, A. Idström, Quentin Lubart, N. Aliakbarinodehi, M. Ojansivu, Hanna M. G. Barriga
Development of efficient lipid nanoparticle (LNP) vectors remains a major challenge towards broad clinical translation of RNA therapeutics. New lipids will be required, but also better understanding LNP interactions with the biological environment. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92a143bde3ce498f1098e5e9d228b7d5
https://doi.org/10.1101/2021.08.20.457104
https://doi.org/10.1101/2021.08.20.457104
Autor:
Sakshi Singh, Laura Trachsel-Moncho, Matthew Yoke Wui Ng, Michael J. Munson, Anne Simonsen, C. Charsou, Ana Lapao, Sigve Nakken
During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called autophagosomes. The origin and identity of the membranes that form the autophagosome remain to be fully characterized. Here, we investigated the role of cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d89959ed80d7431dc16074014fcb2c9a
https://doi.org/10.1101/2021.08.04.455032
https://doi.org/10.1101/2021.08.04.455032