Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Michael J, Kelso"'
Autor:
Kiel Hards, Chen-Yi Cheung, Natalie Waller, Cara Adolph, Laura Keighley, Zhi Shean Tee, Liam K. Harold, Ayana Menorca, Richard S. Bujaroski, Benjamin J. Buckley, Joel D. A. Tyndall, Matthew B. McNeil, Kyu Y. Rhee, Helen K. Opel-Reading, Kurt Krause, Laura Preiss, Julian D. Langer, Thomas Meier, Erik J. Hasenoehrl, Michael Berney, Michael J. Kelso, Gregory M. Cook
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.
Externí odkaz:
https://doaj.org/article/dae3bf53428948ca8c7fbb2eb80c8d45
Autor:
Kiem Vu, Benjamin J. Buckley, Richard S. Bujaroski, Eduardo Blumwald, Michael J. Kelso, Angie Gelli
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Fungal infections have become an increasing threat as a result of growing numbers of susceptible hosts and diminishing effectiveness of antifungal drugs due to multi-drug resistance. This reality underscores the need to develop novel drugs with uniqu
Externí odkaz:
https://doaj.org/article/9f2a367dfa99493b98e4fd848a7e2a1a
Autor:
Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1309 (2022)
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules. Human P2X7 can be partially inhib
Externí odkaz:
https://doaj.org/article/ec5409f7111249ca998740badc225245
Autor:
Sarah E. Hancock, Ramesh Ailuri, David L. Marshall, SimonH.J. Brown, Jennifer T. Saville, Venkateswara R. Narreddula, Nathan R. Boase, BerwyckL.J. Poad, Adam J. Trevitt, MarkD.P. Willcox, Michael J. Kelso, Todd W. Mitchell, Stephen J. Blanksby
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1510-1518 (2018)
The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are structurally related to the general class of FA esters of hydroxy FAs (FAHFAs), the ultra-l
Externí odkaz:
https://doaj.org/article/75e7c317588d447f82e39acf63c176b5
Autor:
Tatiana Johnston, Daria Van Tyne, Roy F. Chen, Nicolas L. Fawzi, Bumsup Kwon, Michael J. Kelso, Michael S. Gilmore, Eleftherios Mylonakis
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract The emergence of Staphylococcus aureus strains resistant to ‘last resort’ antibiotics compels the development of new antimicrobials against this important human pathogen. We found that propyl 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-car
Externí odkaz:
https://doaj.org/article/7742937839174b2885ea370d1062d0f8
Autor:
Mingdong Huang, Haibo Yu, Longguang Jiang, Nehad El Salamouni, Benjamin J. Buckley, Michael J. Kelso, Marie Ranson
Publikováno v:
Journal of Medicinal Chemistry. 65:1933-1945
The urokinase plasminogen activator (uPA) plays a critical role in tumor cell invasion and migration and is a promising anti-metastasis target. 6-Substituted analogs of 5-N,N-(hexamethylene)amiloride (HMA) are potent and selective uPA inhibitors that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28578fa6df87bf80a576f693c3b6d1b3
https://doi.org/10.1021/acs.jmedchem.1c01423
https://doi.org/10.1021/acs.jmedchem.1c01423
Autor:
Rajamohammed Khader, Nagendran Tharmalingam, Biswajit Mishra, LewisOscar Felix, Frederick M. Ausubel, Michael J. Kelso, Eleftherios Mylonakis
Publikováno v:
Antibiotics, Vol 9, Iss 8, p 449 (2020)
There is a significant need to combat the growing challenge of antibacterial drug resistance. We have previously developed a whole-animal dual-screening platform that first used the nematode Caenorhabditis elegans, to identify low-toxicity antibacter
Externí odkaz:
https://doaj.org/article/221f0128c81d4ef1ab38bea2d3818438
Autor:
Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Ashraf Aboelela, Richard S. Bujaroski, Hiwa Majed, Alejandra Rangel, David J. Adams, Marie Ranson, Michael J. Kelso, Benjamin J. Buckley
Acid-sensing ion channels (ASICs) are transmembrane sensors of extracellular acidosis and potential drug targets in several disease indications, including neuropathic pain and cancer metastasis. The K+-sparing diuretic amiloride is a moderate non-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba14ffe5766c44ccd30f35396253dd5
https://doi.org/10.1101/2022.03.12.484055
https://doi.org/10.1101/2022.03.12.484055
Autor:
Mark A. T. Blaskovich, Vikashini Ravikumar, Mark E. Cooper, Michael J. Kelso, Johannes Zuegg, M. Reza Naimi-Jamal, Scott A. Rice, Gregory M. Cook, Ardeshir Rineh, Saul N. Faust, Wee Han Poh, Myron Christodoulides, Chen-Yi Cheung, Alysha G. Elliott, Timothy McEwan, Odel Soren, Fereshteh Azamifar, Jeremy S. Webb, Victoria Dolange
Publikováno v:
ACS Infectious Diseases. 6:1460-1479
The formation of biofilms provides a formidable defense for many bacteria against antibiotics and host immune responses. As a consequence, biofilms are thought to be the root cause of most chronic infections, including those occurring on medical indw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929661a65e3cf2197d528f14a17f4408
https://doi.org/10.1021/acsinfecdis.0c00070
https://doi.org/10.1021/acsinfecdis.0c00070
Publikováno v:
Biophys Rev
The urokinase plasminogen activator (uPA) is a widely studied anticancer drug target with multiple classes of inhibitors reported to date. Many of these inhibitors contain amidine or guanidine groups, while others lacking these groups show improved o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51637536842508fa7e9310e77faa6928
https://doi.org/10.31219/osf.io/3z5m4
https://doi.org/10.31219/osf.io/3z5m4