Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Michael J, James"'
Autor:
Koichi Sudo, Amber Delmas-Eliason, Shannon Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney L. Hegner, Henry D. Dionne, Alex Rodriguez-Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, Daniel Schultz, Mark S. Sundrud
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101392- (2024)
Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e., ileum), yet the dynamics through which complex BA
Externí odkaz:
https://doaj.org/article/4c920e38c9f24de48d0c7062be6a9281
Autor:
David Lubkowicz, Nicholas G Horvath, Michael J James, Pasquale Cantarella, Lauren Renaud, Christopher G Bergeron, Ron B Shmueli, Cami Anderson, Jian‐Rong Gao, Caroline B Kurtz, Mylene Perreault, Mark R Charbonneau, Vincent M Isabella, David L Hava
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 3, Pp 1-17 (2022)
Abstract Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH. SYNB8802 is an
Externí odkaz:
https://doaj.org/article/b6d895d2871d4ce49bd1ee066df28241
Autor:
Aida Kalantari, Michael J James, Lauren A Renaud, Mylene Perreault, Catherine E Monahan, Mary N McDonald, David L Hava, Vincent M Isabella
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0280499 (2023)
E. coli Nissle (EcN) is a non-pathogenic probiotic bacterium of the Enterobacteriaceae family that has been used for over a century to promote general gut health. Despite the history of safe usage of EcN, concerns have been raised regarding the prese
Externí odkaz:
https://doaj.org/article/8e875cfb2bbe4ee59d9f23a67d648b46
Autor:
Daniel S. Leventhal, Anna Sokolovska, Ning Li, Christopher Plescia, Starsha A. Kolodziej, Carey W. Gallant, Rudy Christmas, Jian-Rong Gao, Michael J. James, Andres Abin-Fuentes, Munira Momin, Christopher Bergeron, Adam Fisher, Paul F. Miller, Kip A. West, Jose M. Lora
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in
Externí odkaz:
https://doaj.org/article/c274837c940442a5b5b9051d086275aa
Autor:
Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104712- (2020)
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is
Externí odkaz:
https://doaj.org/article/2065928935b24bed8f41f6623a293ece
Autor:
Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-15 (2018)
Abstract Background Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associa
Externí odkaz:
https://doaj.org/article/7b269cf690304cafbdd47c2d8a1a0c7a
Autor:
Nantachai Inprung, Hon Eong Ho, James A. Rossi-Ashton, Ryan G. Epton, Adrian C. Whitwood, Jason M. Lynam, Richard J. K. Taylor, Michael J. James, William P. Unsworth
Publikováno v:
Organic Letters. 24:668-674
Indole-ynones have been established as general substrates for radical dearomatizing spirocyclization cascade reactions. Five distinct and varied synthetic protocols have been developed─cyanomethylation, sulfonylation, trifluoromethylation, stannyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3217e7dca5f5085e4e5f9eddc1fd622e
https://doi.org/10.1021/acs.orglett.1c04098
https://doi.org/10.1021/acs.orglett.1c04098
Autor:
Andrew J. Greener, Ivan Ocaña, Victor Chechik, Will Owens-Ward, Michael J. James, Patrycja Ubysz, George Smith, Adrian C. Whitwood
Publikováno v:
Chemical Science
The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e46c05448ccb01c4748694d2a03407
http://europepmc.org/articles/PMC8580057
http://europepmc.org/articles/PMC8580057
Autor:
Todd C. Ream, Michael J. James
Publikováno v:
Hesburgh of Notre Dame ISBN: 9783031124778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f54cab99336bd082c01581ac60c3180f
https://doi.org/10.1007/978-3-031-12478-5_1
https://doi.org/10.1007/978-3-031-12478-5_1
Autor:
Todd C. Ream, Michael J. James
Publikováno v:
Hesburgh of Notre Dame ISBN: 9783031124778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8722eaff24c351f5f4de0f4a6e1d260
https://doi.org/10.1007/978-3-031-12478-5_10
https://doi.org/10.1007/978-3-031-12478-5_10