Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Michael J, Holliday"'
Autor:
Mark Ultsch, Michael J. Holliday, Stefan Gerhardy, Paul Moran, Suzie J. Scales, Nidhi Gupta, Francesca Oltrabella, Cecilia Chiu, Wayne Fairbrother, Charles Eigenbrot, Daniel Kirchhofer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Mark Ultsch et al. report X-ray and NMR structures of the N-terminal domain of two closely related innate immunity proteins, ApoL1 and ApoL2. Their findings contribute to a better understanding of the ApoL immune protein family.
Externí odkaz:
https://doaj.org/article/55aec271b9224cfebb44d9647b2ae582
Autor:
Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber, Wayne J. Fairbrother
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the struct
Externí odkaz:
https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
Autor:
Micah Steffek, Elizabeth Helgason, Nataliya Popovych, Lionel Rougé, John M. Bruning, Ke Sherry Li, Daniel J. Burdick, Jianping Cai, Terry Crawford, Jing Xue, Willy Decurtins, Chunlin Fang, Felix Grubers, Michael J. Holliday, Allyson Langley, Ann Petersen, Alexander Lee Satz, Aimin Song, Daniel Stoffler, Quentin Strebel, Jeffrey Y. K. Tom, Nicholas Skelton, Steven T. Staben, Moreno Wichert, Melinda M. Mulvihill, Erin C. Dueber
Publikováno v:
Biochemistry. 62:633-644
Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) famil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c00ab7c9a5fb6957dbd609eeeeb525
https://doi.org/10.1021/acs.biochem.1c00682
https://doi.org/10.1021/acs.biochem.1c00682
Autor:
Charles Eigenbrot, Paul Moran, Stefan Gerhardy, Cecilia Chiu, Suzie J. Scales, Michael J. Holliday, Nidhi Gupta, Francesca Oltrabella, Wayne J. Fairbrother, Mark Ultsch, Daniel Kirchhofer
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly increased risk of chronic kidney disease. Here we present X-ray and NMR struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caf4f7a8e9144eb00a3df9a4b830e89
https://doi.org/10.1038/s42003-021-02387-5
https://doi.org/10.1038/s42003-021-02387-5
Publikováno v:
The Journal of Physical Chemistry B. 122:2368-2378
One-dimensional heteronuclear relaxation dispersion NMR spectroscopy at 13C natural abundance successfully characterized the dynamics of the hydrogen–deuterium exchange reaction occurring at the Ne position in l-arginine by monitoring Cδ in varyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afdb08d303e7d5f5c9c6f7989db3ac0
https://doi.org/10.1021/acs.jpcb.7b10849
https://doi.org/10.1021/acs.jpcb.7b10849
Streptococcus pneumoniaeIgA1 protease: A metalloprotease that can catalyze in a split mannerin vitro
Autor:
Jeremy T Rahkola, Thomas S. Roberts, Agnieszka A. Kendrick, Michael J. Holliday, Elan Z. Eisenmesser, Ying-Chih Chi, Edward N. Janoff, Natasia Paukovich
Publikováno v:
Protein Science. 26:600-610
IgA1 proteases (IgA1P) from diverse pathogenic bacteria specifically cleave human immunoglobulin A1 (IgA1) at the hinge region, thereby thwarting protective host immune responses. Streptococcus pneumoniae (S. pneumoniae) IgA1P shares no sequence cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6764d338262a218c75bb262c0748f36c
https://doi.org/10.1002/pro.3110
https://doi.org/10.1002/pro.3110
Autor:
Michele Vendruscolo, Elan Z. Eisenmesser, Geoffrey S. Armstrong, Carlo Camilloni, Michael J. Holliday
Publikováno v:
Structure. 25:276-286
Many protein systems rely on coupled dynamic networks to allosterically regulate function. However, the broad conformational space sampled by non-coherently dynamic systems has precluded detailed analysis of their communication mechanisms. Here, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f38f52d069c1351fb79bcd631cc10b
https://doi.org/10.1016/j.str.2016.12.003
https://doi.org/10.1016/j.str.2016.12.003
Autor:
Gladys de Leon Boenig, Alexis Rohou, Ryan Ferrao, Erin C. Dueber, Wayne J. Fairbrother, Elizabeth Helgason, Alberto Estevez, Michael J. Holliday
Publikováno v:
The Journal of biological chemistry. 293(43)
The caspase recruitment domain–containing protein 9 (CARD9)–B-cell lymphoma/leukemia 10 (Bcl10) signaling axis is activated in myeloid cells during the innate immune response to a variety of diverse pathogens. This signaling pathway requires a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee2181f756d887f83e79be962ad65dd
https://pubmed.ncbi.nlm.nih.gov/30206119
https://pubmed.ncbi.nlm.nih.gov/30206119
Autor:
Nancy G. Isern, Glenn C. Capodagli, Scott D. Pegan, Fengli Zhang, Michael J. Holliday, Elan Z. Eisenmesser, Geoffrey S. Armstrong
Publikováno v:
Protein Science. 24:651-660
Crimean-Congo Hemorrhagic fever virus (CCHFV) is one of several lethal viruses that encodes for a viral ovarian tumor domain (vOTU), which serves to cleave and remove ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) from numerous prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c28bfe4524b45dfc416de3f014b7732
https://doi.org/10.1002/pro.2637
https://doi.org/10.1002/pro.2637
Autor:
Agnieszka A. Kendrick, Carlo Camilloni, Michele Vendruscolo, Chi Huynh, Elan Z. Eisenmesser, Michael J. Holliday, Nancy G. Isern, Geoffrey S. Armstrong, Fengli Zhang
Publikováno v:
Protein Science. 23:464-480
Interleukin-8 (CXCL8, IL-8) is a proinflammatory chemokine important for the regulation of inflammatory and immune responses via its interaction with G-protein coupled receptors, including CXC receptor 1 (CXCR1). CXCL8 exists as both a monomer and as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adaea70f9b6479710703af5c53e8c318
https://doi.org/10.1002/pro.2430
https://doi.org/10.1002/pro.2430