Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Michael J, Hawkins"'
Autor:
William A. Mitchell, Michael J. Hawkins, Michael J. Lannoo, Rochelle M. Stiles, Chris H. La Rue
Publikováno v:
Journal of North American Herpetology. :70-79
Over the next half-century, scientists anticipate that nearly one third of the currently recognized 7,450 amphibian species will become extinct. Many organizations have responded to the challenge of conserving amphibian biodiversity, some indirectly.
Publikováno v:
North American Journal of Fisheries Management. 33:26-31
We evaluated the effects of fish length, fish sex, and number of days posttagging on retention of large-format, soft visible implant (VI) alphanumeric tags that were injected underneath the clear tissue on the lower mandible of Walleyes Sander vitreu
Autor:
Anita Reddy, Susan O'Brien, Paul M. Barr, Julie A. Di Paolo, Jing Hu, Daniel Reif Greenwald, Stephen E. Spurgeon, Hank Lee, Michael J. Hawkins, Lyndah Dreiling, Bruce D. Cheson, Andre K. D. Liem, Rosemary E. Mclntyre, Esteban Abella-Dominicis, Gene Brian Saylors, Joyce He, Jonathan W. Friedberg, Adarsh Joshi
Publikováno v:
Blood. 127(20)
Although agents targeting B-cell receptor signaling have provided practice-changing results in relapsed chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), they require prolonged administration and provide incomplete responses. Given s
Autor:
Douglas H. Thamm, Michael J. Hawkins, Darius Babusis, Christie Anderson, David M. Vail, William J. Watkins, Hans Reiser, Grushenka H.I. Wolfgang, Jessica Lawrence, Robert Jeraj, M Vanderhoek, Mackenzie A. Wessel, Ilana N. Henne, Ilene D. Kurzman, Adrian S. Ray, Daniel B. Tumas, Cecilia S. Robat, Susan Plaza
Publikováno v:
Clinical Cancer Research. 15:3503-3510
Purpose: To assess, in dogs with naturally occurring non-Hodgkin's lymphoma, pharmacokinetics, safety, and activity of GS-9219, a prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG), which delivers PMEG and its phosphorylat
Autor:
Alex Sparreboom, William D. Figg, Charity D. Scripture, Jacquin Jones, Neil Desai, Erin R. Gardner, Jeanny B. Aragon-Ching, William L. Dahut, Michael J. Hawkins
Publikováno v:
Clinical Cancer Research. 14:4200-4205
Purpose: Abraxane (ABI-007) is a 130-nm albumin-bound (nab) particle formulation of paclitaxel, devoid of any additional excipients. We hypothesized that this change in formulation alters the systemic disposition of paclitaxel compared with conventio
Publikováno v:
Journal of Freshwater Ecology. 22:231-239
We examined precision in age estimates from common carp (Cyprinus carpio) scales and dorsal spines sampled from 28 Iowa lakes (N = 501 individual fish). Exact agreement between two readers was 28.5% for scales and 90.6% for dorsal spines. Agreement o
Autor:
Lisa Minor, Yuanping Wang, Michael J. Hawkins, Enrico Di Cera, Jeffrey Hall, Thomas W. Corcoran, Angelene M. Cantwell, Bruce E. Maryanoff, Savvas N. Savvides, Michael N. Greco, Powell Eugene, Lawrence de Garavilla, Harold R. Almond, Bruce P. Damiano
Publikováno v:
Journal of Medicinal Chemistry. 50:1727-1730
A series of beta-carboxamido-phosphon(in)ic acids (2) was identified as a new structural motif for obtaining potent inhibitors of human mast cell chymase. For example, 1-naphthyl derivative 5f had an IC50 value of 29 nM and (E)-styryl derivative 6g h
Autor:
Jeff P. Sharman, Michael Boxer, Michael J. Hawkins, Jing Hu, Steve Abella, Leonard M. Klein, Kathryn S. Kolibaba, Chris A. Yasenchak, Meihua Wu
Small-molecule inhibitors of kinases involved in B-cell receptor signaling are an important advance in managing lymphoid malignancies. Entospletinib (GS-9973) is an oral, selective inhibitor of spleen tyrosine kinase. This multicenter, phase 2 study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185fc1aec697bc2af87845a46c38f1a7
https://europepmc.org/articles/PMC4401348/
https://europepmc.org/articles/PMC4401348/
Autor:
Kelly Richardson, Daniel D. Von Hoff, Evan M. Hersh, Neil Desai, David W. Nyman, Vuong Trieu, Kimberley J. Campbell, Michael J. Hawkins, Kristen Long
Publikováno v:
Journal of Clinical Oncology. 23:7785-7793
Purpose ABI-007 is a novel solvent-free, albumin-bound, 130-nm particle formulation of paclitaxel designed to avoid solvent-related toxicities and to deliver paclitaxel to tumors via molecular pathways involving an endothelial cell-surface albumin re
Autor:
H. Xin, Michael N. Greco, Margery A. Connelly, M.W. Olson, G.C. Leo, B.P. Damiano, D.J. Hlasta, A.L. Darrow, Celine Schalk-Hihi, C. Smith, Wensheng Lang, Z. Huang, Eugene Powell, Michael J. Hawkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2595-2597
By screening directed libraries of serine hydrolase inhibitors using the cell surface form of endothelial lipase (EL), we identified a series of carbamate-derived (EL) inhibitors. Compound 3 raised plasma HDL-C levels in the mouse, and a correlation