Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Michael J, Guertin"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011159 (2024)
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout. We introduced an inducible degron t
Externí odkaz:
https://doaj.org/article/1ea7745be3074667b30911fbb237b595
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Ankyrin repeat and LEM-domain containing protein 1 (ANKLE1) cleaves the mitochondrial genome during erythropoiesis and ectopic expression of ANKLE1 promotes genome instability and apoptotic resistance, which contributes to breast cancer risk.
Externí odkaz:
https://doaj.org/article/10380796a8d34cd785888d5904222065
Autor:
Shengen Shawn Hu, Lin Liu, Qi Li, Wenjing Ma, Michael J. Guertin, Clifford A. Meyer, Ke Deng, Tingting Zhang, Chongzhi Zang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been widely used to identify regulatory DNA elements and transcription factor binding sites. Here the authors develop a computational model, SELMA, to estimate and correct
Externí odkaz:
https://doaj.org/article/4928d7b0b5bf4fbcbbd9bf89f5fb0a0e
Autor:
Jason P. Smith, Arun B. Dutta, Kizhakke Mattada Sathyan, Michael J. Guertin, Nathan C. Sheffield
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Nascent RNA profiling is growing in popularity; however, there is no standard analysis pipeline to uniformly process the data and assess quality. Here, we introduce PEPPRO, a comprehensive, scalable workflow for GRO-seq, PRO-seq, and ChRO-se
Externí odkaz:
https://doaj.org/article/4f2f6e582db742b0b55f5d0e1c0ead17
Autor:
Katherine Pfister, Justyna L. Pipka, Colby Chiang, Yunxian Liu, Royden A. Clark, Ray Keller, Paul Skoglund, Michael J. Guertin, Ira M. Hall, P. Todd Stukenberg
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2758-2769 (2018)
Although aneuploidy is found in the majority of tumors, the degree of aneuploidy varies widely. It is unclear how cancer cells become aneuploid or how highly aneuploid tumors are different from those of more normal ploidy. We developed a simple compu
Externí odkaz:
https://doaj.org/article/0f495ebe7d2f49058195f23bde14cdf0
Autor:
Anniina Vihervaara, Dig Bijay Mahat, Michael J. Guertin, Tinyi Chu, Charles G. Danko, John T. Lis, Lea Sistonen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancer
Externí odkaz:
https://doaj.org/article/8396af8fe6874b93839c2a87662af811
Autor:
Sylwia Hasterok, Thomas G. Scott, Devin G. Roller, Adam Spencer, Arun B. Dutta, Kizhakke M Sathyan, Daniel E. Frigo, Michael J. Guertin, Daniel Gioeli
The clinical success of combined androgen deprivation therapy (ADT) and radiation therapy (RT) in prostate cancer (PCa) created interest in understanding the mechanistic links between androgen receptor (AR) signaling and the DNA damage response (DDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c389664a3c8cb66537286b0269663bc4
https://doi.org/10.1101/2023.05.13.540653
https://doi.org/10.1101/2023.05.13.540653
Precision genomic run-on assays (PRO-seq) quantify nascent RNA at single nucleotide resolution with strand specificity. Here we deconstruct a recently published genomic nascent RNA processing pipeline (PEPPRO) into its components and link the analyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af106fa48f2c71d0657ee1bf3ac2ba0
https://doi.org/10.1101/2022.12.14.520463
https://doi.org/10.1101/2022.12.14.520463
Chromatin accessibility assays have revolutionized the field of transcription regulation by providing single-nucleotide resolution measurements of regulatory features such as promoters and transcription factor binding sites. ATAC-seq directly measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86677dbbb082148eecd3dbe2eb7a0c29
https://doi.org/10.1101/2022.12.08.519600
https://doi.org/10.1101/2022.12.08.519600
Autor:
Yunxian Liu, Ninad M Walavalkar, Mikhail G Dozmorov, Stephen S Rich, Mete Civelek, Michael J Guertin
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006761 (2017)
Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants responsible for risk remain uncharacterized. The majority of GWAS-identified loci are enriched for no
Externí odkaz:
https://doaj.org/article/eaa2d3ee0d064570bfd5fb317f55a212