Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Michael J, Frank"'
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/744b20333bf649908247c2e42e85813b
Autor:
Alana Jaskir, Michael J Frank
Publikováno v:
eLife, Vol 12 (2023)
The basal ganglia (BG) contribute to reinforcement learning (RL) and decision-making, but unlike artificial RL agents, it relies on complex circuitry and dynamic dopamine modulation of opponent striatal pathways to do so. We develop the OpAL* model t
Externí odkaz:
https://doaj.org/article/8f14f377c3f34141a0ec1a5a69598e23
Autor:
Daniel Umbricht, Markus Abt, Paul Tamburri, Christopher Chatham, Štefan Holiga, Michael J. Frank, Anne G.E. Collins, David P. Walling, Rick Mofsen, Daniel Gruener, Lev Gertsik, Jeff Sevigny, Sanjay Keswani, Juergen Dukart
Publikováno v:
Biological Psychiatry Global Open Science, Vol 1, Iss 1, Pp 70-77 (2021)
Background: Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum,
Externí odkaz:
https://doaj.org/article/4e96e9575d7248e086f19bdc0d374f88
Publikováno v:
Computational Psychiatry, Vol 4, Pp 18-39 (2020)
Schizophrenia is associated with a number of deficits in decision-making, but the scope, nature, and cause of these deficits are not completely understood. Here we focus on a particular type of decision, known as the explore/exploit dilemma, in which
Externí odkaz:
https://doaj.org/article/dde8da1092c04ae8a3e57a97beabd2aa
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009854 (2022)
Adaptive sequential behavior is a hallmark of human cognition. In particular, humans can learn to produce precise spatiotemporal sequences given a certain context. For instance, musicians can not only reproduce learned action sequences in a context-d
Externí odkaz:
https://doaj.org/article/95df48191aa14812ad46f53a29668244
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The sex hormone estradiol has recently gained attention in human decision-making research. Animal studies have already shown that estradiol promotes dopaminergic transmission and thus supports reward-seeking behavior and aspects of addiction. In huma
Externí odkaz:
https://doaj.org/article/8e96950d55bf44ee8d9d51ff82a39475
Autor:
Nicole R. Provenza, Luiz Fernando Fracassi Gelin, Wasita Mahaphanit, Mary C. McGrath, Evan M. Dastin-van Rijn, Yunshu Fan, Rashi Dhar, Michael J. Frank, Maria I. Restrepo, Wayne K. Goodman, David A. Borton
Publikováno v:
Brazilian Journal of Psychiatry (2021)
Objective: To improve the ability of psychiatry researchers to build, deploy, maintain, reproduce, and share their own psychophysiological tasks. Psychophysiological tasks are a useful tool for studying human behavior driven by mental processes such
Externí odkaz:
https://doaj.org/article/8c214c7a113940d18799ea6c731d2931
Publikováno v:
Computational Psychiatry, Vol 3, Pp 1-17 (2019)
In this report, we provide the first evidence that mood and anxiety dimensions are associated with unique aspects of EEG responses to reward and punishment, respectively. We reanalyzed data from our prior publication of a categorical depiction of dep
Externí odkaz:
https://doaj.org/article/3de9ed550d3a4a6a8fe06f56f6f2e4f7
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1008971 (2021)
Adaptive cognitive-control involves a hierarchical cortico-striatal gating system that supports selective updating, maintenance, and retrieval of useful cognitive and motor information. Here, we developed a task that independently manipulates selecti
Externí odkaz:
https://doaj.org/article/d0722276fb5a417b83342b9ab5bd40eb
Autor:
Mads L Pedersen, Maria Ironside, Ken-Ichi Amemori, Callie L McGrath, Min S Kang, Ann M Graybiel, Diego A Pizzagalli, Michael J Frank
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008955 (2021)
Adaptive behavior requires balancing approach and avoidance based on the rewarding and aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a no
Externí odkaz:
https://doaj.org/article/55484652180941709b407961d8e3f9fb