Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers

Autor: Miles Berger, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W. Michael Bullock, Brian J. Colin, Michael J. Devinney, Eugene W. Moretti, Judd W. Moul, Brian Ohlendorf, Daniel T. Laskowitz, Teresa Waligorska, Leslie M. Shaw, Heather E. Whitson, Harvey J. Cohen, Joseph P. Mathew, the MADCO‐PC Investigators

Publikováno v: Annals of Clinical and Translational Neurology, Vol 9, Iss 2, Pp 155-170 (2022)

Abstract Objective Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cogni

Externí odkaz: https://doaj.org/article/1c089ccb83b44b2ca60d535fdc84454a

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study

Autor: Marty G. Woldorff, Grant E. Garrigues, Ayesha Syed, Jeffrey N. Browndyke, Heather E. Whitson, X. Wang, A. Peterson, J. Lemm, W. Lee, S. Grant, F. Sbahi, C. Young, J. Thacker, Y. Toulgoat-Dubois, A. Khan, Quintin J Quinones, Jeff Gadsden, Kenneth C. Roberts, J. Chapman, Dhanesh K. Gupta, Michael J. Devinney, H. Levinson, A. Ray, L. Talbot, Michael N. Ferrandino, A. Perez, Leslie M. Shaw, Brian J. Colin, J. DeOrio, Ashley Hall, S. Roman, Randall P. Scheri, J. Guercio, S. Lagoo-Deenadayalan, B. Inman, Teresa Waligorska, Katherine T. Martucci, Rosa Yang, T. D'Amico, R. Brassard, C. Mantyh, K. Smith, J. Gardner, Aaron J. Sandler, John Park, B. Tong, N. Waldron, S. Bengali, Harvey J. Cohen, S. Vaslef, Judd W. Moul, D. Harpole, Ashraf S. Habib, Ellen Bennett, J. Carter, Charles M. Giattino, J. Migaly, S. Runyon, B. Brigman, M. Bullock, G. Preminger, E. Iboaya, Brian Ohlendorf, Eugene W. Moretti, Joseph P. Mathew, P. Lee, Miles Berger, A. Tu, C. Robertson, Jake Thomas, J. Hu, Mary Cooter Wright, Daniel T. Laskowitz, David L. McDonagh, M. Hartwig, S. Mithani, R. Esclamado, Mark F. Newman

Publikováno v: British Journal of Anaesthesia. 127:917-928

Background Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. Methods We enrolled 140 English-speaking patients ≥60 yr old schedu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6605d42ec8e6674e903ffe769593f4
https://doi.org/10.1016/j.bja.2021.08.012

3111 Heart Rate Variability as a Predictor of Post-Operative Cognitive Dysfunction in Older Adults

Autor: Deborah Oyeyemi, Miles Berger, Kenneth C. Roberts, Charles M. Giattino, Marty G. Woldorff, Cathleen Colon-Emeric, Michael J. Devinney, Thomas Bunning, Junhong Zhou, Lewis A. Lipsitz, Heather E. Whitson

Publikováno v: Journal of Clinical and Translational Science, Vol 3, Pp 46-46 (2019)

OBJECTIVES/SPECIFIC AIMS: The objective of this project is to determine whether HRV, collected peri-operatively, is predictive of cognitive decline among older adults who undergo elective surgery/anesthesia. METHODS/STUDY POPULATION: This project is

Externí odkaz: https://doaj.org/article/b0714f0efef542049fe75cdb433f77c2

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults

Autor: Aaron J. Sandler, Ashraf S. Habib, Miles Berger, Mary Cooter, Brian J. Colin, Michael N. Ferrandino, Jeff Gadsden, Madco-Pc, Intuit Investigators Teams, Randall P. Scheri, Judd W. Moul, Christopher C. Young, Brian Ohlendorf, Jake Thomas, Grant E. Garrigues, Eugene W. Moretti, Joseph P. Mathew, W. Michael Bullock, Michael J. Devinney, Bharat Sharma, Chloe Nobuhara, Thomas Bunning

Publikováno v: J Neurol

OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two coh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5fe8ded53e7c32c5e4b215688d1c6b
https://doi.org/10.1007/s00415-020-09797-1

A New Severity Scoring Scale for the 3‐Minute Confusion Assessment Method ( 3D‐CAM )

Autor: Michael J. Devinney, Richard Huang, Sarinnapha M. Vasunilashorn, Miles Berger, Yoojin Jung, Mary Cooter, Leah Acker, Edward R. Marcantonio, Long Ngo

Publikováno v: J Am Geriatr Soc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa757e42e97687792ac184e6b776d5b
https://doi.org/10.1111/jgs.16538