Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Michael J, Chappell"'
Publikováno v:
Healthcare Technology Letters, Vol 11, Iss 1, Pp 1-15 (2024)
Abstract The goal of this paper is twofold: firstly, to provide a novel mathematical model that describes the kinematic chain of motion of the human fingers based on Lagrangian mechanics with four degrees of freedom and secondly, to estimate the mode
Externí odkaz:
https://doaj.org/article/d339d02cd5874003af5bc56995d132a3
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Tyrosine kinase inhibitors (TKIs) are routinely prescribed for the treatment of non‐small cell lung cancer (NSCLC). As with all medications, patients can experience adverse events due to TKIs. Unfortunately, the relationship between many T
Externí odkaz:
https://doaj.org/article/8e7bfcd84eb24fe892cbcd96e5964bdb
Publikováno v:
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, Vol 11, Iss 7 (2024)
Upper-limb prostheses are either too expensive for many consumers or have a greatly simplified choice of actions. This research aims to enable an improvement to the quality of life for recipients of these devices by providing an understanding of how
Externí odkaz:
https://doaj.org/article/08964e8d84224bc18c4b46057dc11020
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 4, Pp 211-221 (2020)
A structurally identifiable micro‐rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goodness‐of‐fit values through comeasurement of pitavastatin and eltrombopag. Transporter
Externí odkaz:
https://doaj.org/article/a5f53b308f794671b966c68b6dd7040b
Autor:
Lourdes Cucurull‐Sanchez, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik‐Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van derGraaf, Paolo Vicini, James W. T. Yates
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 259-272 (2019)
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermin
Externí odkaz:
https://doaj.org/article/293fdfa59097477883b9efaa13afb99e
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant rej
Externí odkaz:
https://doaj.org/article/f4419d9338704737b240e0fdd9eb98e5
Publikováno v:
International Journal of Antimicrobial Agents. 60:106641
Mathematical modelling has made significant contributions to the optimization of the use of antimicrobial treatments. This article discusses the key processes that such mathematical modelling should attempt to capture. In particular, this article hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358d4d60dfa4e01b75aae72c615d9d93
https://doi.org/10.1016/j.ijantimicag.2022.106641
https://doi.org/10.1016/j.ijantimicag.2022.106641
Autor:
Karelle Ménochet, Lloyd M. King, Alex S. Ferecskó, Michael J. Chappell, Ted Parton, Simon J. Carter
Publikováno v:
Xenobiotica. 50:415-426
Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method.Atorvastatin was incu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ac841fe46e409c23b09622555095e3
https://doi.org/10.1080/00498254.2019.1652781
https://doi.org/10.1080/00498254.2019.1652781
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
IEEE Control Systems Letters
instname
IEEE Control Systems Letters
6 pages, 2 figures.-- Open access
A dynamic model is structurally identifiable if it is possible to infer its unknown parameters by observing its output. Structural identifiability depends on the system dynamics, output, and input, as well as on
A dynamic model is structurally identifiable if it is possible to infer its unknown parameters by observing its output. Structural identifiability depends on the system dynamics, output, and input, as well as on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae6e18e9310363e340fa2a75ba37ba6
https://doi.org/10.1109/lcsys.2018.2868608
https://doi.org/10.1109/lcsys.2018.2868608
Publikováno v:
Computer Methods and Programs in Biomedicine. 171:141-152
Background and objective Structural identifiability is a concept that considers whether the structure of a model together with a set of input–output relations uniquely determines the model parameters. In the mathematical modelling of biological sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812338ce04da55d80f81a83b9402019f
https://doi.org/10.1016/j.cmpb.2016.04.024
https://doi.org/10.1016/j.cmpb.2016.04.024