Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael J, Bromley"'
Autor:
Norman van Rhijn, Can Zhao, Narjes Al-Furaiji, Isabelle S. R. Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael-Fortune Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo H. Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel A. Brakhage, Hubertus Haas, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these infections but resistance is rising, therefore the identificat
Externí odkaz:
https://doaj.org/article/b48ee6e7b3ac4ef8ac88712d8df32311
Autor:
Norman van Rhijn, Can Zhao, Narjes Al-Furaiji, Isabelle S. R. Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael-Fortune Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo H. Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel A. Brakhage, Hubertus Haas, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e844ea14cdc94abd9b868de3f1484f0e
Autor:
Kayleigh Earle, Clara Valero, Daniel P. Conn, George Vere, Peter C. Cook, Michael J. Bromley, Paul Bowyer, Sara Gago
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTPulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences arising from immunosuppression, chronic respiratory conditions or more recently, concomit
Externí odkaz:
https://doaj.org/article/28fba6ca9c5c47768dacfe06c61cb53f
Publikováno v:
Journal of Fungi, Vol 10, Iss 5, p 327 (2024)
The mold Aspergillus fumigatus employs two high-affinity uptake systems, reductive iron assimilation (RIA) and siderophore-mediated iron acquisition (SIA), for the acquisition of the essential trace element iron. SIA has previously been shown to be c
Externí odkaz:
https://doaj.org/article/30c18c33390640d7aac466ada5bdb074
Autor:
Jane T. Jones, Kaesi A. Morelli, Elisa M. Vesely, Charles T. S. Puerner, Chetan K. Pavuluri, Brandon S. Ross, Norman van Rhijn, Michael J. Bromley, Robert A. Cramer
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT People with cystic fibrosis (pwCF) commonly test positive for the pathogenic fungus Aspergillus fumigatus, which is associated with a decline in lung function. Trikafta is a recently approved therapy for pwCF that improves quantity and funct
Externí odkaz:
https://doaj.org/article/098d58ffb46747e4a7339172e4604e5e
Autor:
Tim J.H. Baltussen, Norman van Rhijn, Jordy P.M. Coolen, Jan Dijksterhuis, Paul E. Verweij, Michael J. Bromley, Willem J.G. Melchers
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Germination of inhaled Aspergillus fumigatus conidia is a necessary sequitur for infection. Germination of conidia starts with the breaking of dormancy, which is initiated by an increase of the cellular perimeter in a process termed isotropi
Externí odkaz:
https://doaj.org/article/4e71b6df36a0471289d1345915d6d14d
Autor:
Norman van Rhijn, Sam Hemmings, Isabelle S. R. Storer, Clara Valero, Hajer Bin Shuraym, Gustavo H. Goldman, Fabio Gsaller, Jorge Amich, Michael J. Bromley
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, t
Externí odkaz:
https://doaj.org/article/c043a17d4d58460cb403d9350c5e2b8a
Autor:
Clara Valero, Ana Cristina Colabardini, Patrícia Alves de Castro, Jorge Amich, Michael J. Bromley, Gustavo H. Goldman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Cell responses against antifungals other than resistance have rarely been studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasingly examined in yeast-like organisms. Aspergil
Externí odkaz:
https://doaj.org/article/546c975ccb58452ab4b40af4f36fecc6
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
Autor:
Alexander Kühbacher, Mandy Peiffer, Peter Hortschansky, Petra Merschak, Michael J. Bromley, Hubertus Haas, Axel A. Brakhage, Fabio Gsaller
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and t
Externí odkaz:
https://doaj.org/article/b64b3732f24548c5bbb8c2445cb492cc
Autor:
Takanori Furukawa, Norman van Rhijn, Marcin Fraczek, Fabio Gsaller, Emma Davies, Paul Carr, Sara Gago, Rachael Fortune-Grant, Sayema Rahman, Jane Mabey Gilsenan, Emma Houlder, Caitlin H. Kowalski, Shriya Raj, Sanjoy Paul, Peter Cook, Josie E. Parker, Steve Kelly, Robert A. Cramer, Jean-Paul Latgé, Scott Moye-Rowley, Elaine Bignell, Paul Bowyer, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primar
Externí odkaz:
https://doaj.org/article/5e2ad52f5b324f87841175e72f74a7dd