Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Michael J, Bradley"'
Publikováno v:
World Leisure Journal. :1-10
Publikováno v:
Journal of Emerging Sport Studies.
Technology remains an important part of outdoor recreation, ranging from the introduction of lighter materials in gear to new gadgets that improve the outdoor experience. Recently, advances in cellular technology and mobile devices have presented new
Autor:
Ashraf Wilsily, Robert Zahler, Nan Ke, Claudio Chuaqui, Michael J. Bradley, Jason J. Marineau, Goran Malojčić, Stephane Ciblat, Anneli Savinainen, Darby Schmidt, Nigel J. Waters, Kristin B. Hamman, Sydney Alnemy, Stephanie Roy, Dana K. Winter, Anzhelika Kabro, Kenneth Matthew Whitmore, Shanhu Hu, Janessa Mihalich
Publikováno v:
Journal of medicinal chemistry. 65(2)
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and s
Autor:
Nan Ke, Yoon Jong Choi, David A. Orlando, Emmanuelle di Tomaso, Kevin Sprott, Christian Fritz, Shanhu Hu, Michael J. Bradley, John Carulli, Darby Schmidt, Eric R. Olson, Stephane Ciblat, Nisha Rajagopal, Jason J. Marineau, J. Graeme Hodgson, Dana K. Winter, Anzhelika Kabro, Yixuan Ren, Kristin B. Hamman, Sydney Alnemy, Liv Johannessen
Publikováno v:
Cancer Research. 79:3479-3491
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and survival. Cyclin-dependent kinase
Publikováno v:
Parks Stewardship Forum. 37
Author(s): Liu, Hung-Ling (Stella); Wu, I-Chun (Nicky); Bradley, Michael J. | Abstract: In the past decade, state government appropriation reductions have forced park agencies to seek other sources of revenue to support park operations. To overcome s
Autor:
Goran Malojčić, Martine Brault, Ines H. Kaltheuner, Lewis C. Cantley, Patrick Deroy, Heeyoun Bunch, Shanhu Hu, Janet Iwasa, Robin D. Dowell, Michael J. Bradley, Christian Clavette, Limei Tao, Peter W. White, Matthias Geyer, Zachary C. Poss, William M. Old, Zachary L. Maas, Shraddha Nayak, Tim-Michael Decker, Christopher C. Ebmeier, Benjamin Erickson, Leah J. Damon, David Bentley, Jenna K. Rimel, Tomer M. Yaron, Jason J. Marineau, Jared L. Johnson, Kristin B. Hamman, Dylan J. Taatjes
Publikováno v:
Genes Dev
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quanti
Publikováno v:
Natural Resources. 10:271-283
The growth and sprawl of the American black bear (Ursus americanus) population have been observed and monitored in the past two decades, especially in south-central Kentucky. To better manage human-black bear interaction and develop informed policy a
Publikováno v:
Natural Resources. 10:358-366
Sinkers are quicksand enthusiasts that crave the sensation of being trapped in deep mud while being sucked downward. Although humans have been interested in quicksand over the years (particularly through film), there remains a void of research into t
Publikováno v:
Journal of Gastronomy and Tourism. 2:153-161
Craft beer tourism, defined as purposeful travel to experience beer culture, taste beers, or tour facilities, is increasing in the US. Although various regions have seen increased craft beer tourism, there is limited information related to beer touri
Publikováno v:
Journal of Experiential Education. 40:187-201
Service learning is becoming a more utilized method of instruction in collegiate settings, and holds the potential to provide a deeper, more transferable meaning of course material for students. The purpose of this research was to examine if therapeu