A Tale of Three Species: Adaptation of Sodalis glossinidius to Tsetse Biology, Wigglesworthia Metabolism, and Host Diet

Autor: Rebecca J. Hall, Lindsey A. Flanagan, Michael J. Bottery, Vicki Springthorpe, Stephen Thorpe, Alistair C. Darby, A. Jamie Wood, Gavin H. Thomas

Publikováno v: mBio, Vol 10, Iss 1 (2019)

ABSTRACT The tsetse fly is the insect vector for the Trypanosoma brucei parasite, the causative agent of human African trypanosomiasis. The colonization and spread of the trypanosome correlate positively with the presence of a secondary symbiotic bac

Externí odkaz: https://doaj.org/article/c0668f1dd80e47818646dc391404b3f5

Resistance evolution can disrupt antibiotic exposure protection through competitive exclusion of the protective species

Autor: Angus M, Quinn, Michael J, Bottery, Harry, Thompson, Ville-Petri, Friman

Publikováno v: The ISME journal. 16(10)

Antibiotic degrading bacteria can reduce the efficacy of drug treatments by providing antibiotic exposure protection to pathogens. While this has been demonstrated at the ecological timescale, it is unclear how exposure protection might alter and be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0818bb14029b98fd67fc5a65f6a4f825
https://pubmed.ncbi.nlm.nih.gov/35859161

Inter-species interactions alter antibiotic efficacy in bacterial communities

Autor: Michael J Bottery, A. Jamie Wood, Helle Krogh Johansen, Jessica L Matthews, Jon W. Pitchford, Ville-Petri Friman

Publikováno v: Bottery, M J, Matthews, J L, Wood, A J, Johansen, H K, Pitchford, J W & Friman, V P 2022, ' Inter-species interactions alter antibiotic efficacy in bacterial communities ', ISME Journal, vol. 16, pp. 812–821 . https://doi.org/10.1038/s41396-021-01130-6
Bottery, M J, Matthews, J L, Wood, A J, Johansen, H K, Pitchford, J W & Friman, V-P 2022, ' Inter-species interactions alter antibiotic efficacy in bacterial communities ', ISME Journal, vol. 16, pp. 812–821 . https://doi.org/10.1038/s41396-021-01130-6

The efficacy of antibiotic treatments targeting polymicrobial communities is not well predicted by conventional in vitro susceptibility testing based on determining minimum inhibitory concentration (MIC) in monocultures. One reason for this is that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f9e0644d5cb74a3f482de7f5f2356c
https://pubmed.ncbi.nlm.nih.gov/34697495

The Sodalis system and flux balance analysis as a tool for investigating insect-microbe interactions and the evolution of symbioses

Autor: Vicki Springthorpe, Jamie Wood, Alistair C. Darby, Lindsey A. Flanagan, Rebecca J Hall, Gavin H. Thomas, Michael J. Bottery, Stephen Thorpe

Publikováno v: Access Microbiology. 1

The development of new microbial growth and analytical techniques is becoming increasingly relevant in relation to ‘unculturable’ organisms. This may involve the modification of existing methods or the development of new, custom procedures. One i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36de4e089b6fed4409c70e4e2302fd45
https://doi.org/10.1099/acmi.ac2019.po0057

Temporal dynamics of bacteria-plasmid coevolution under antibiotic selection

Autor: Michael J, Bottery, A Jamie, Wood, Michael A, Brockhurst

Publikováno v: The ISME Journal

Horizontally acquired genes can be costly to express even if they encode useful traits, such as antibiotic resistance. We previously showed that when selected with tetracycline, Escherichia coli carrying the tetracycline-resistance plasmid RK2 evolve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b42ce60e715540a27a031f4c55e83dc3
https://pubmed.ncbi.nlm.nih.gov/30209344