Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael J, Banker"'
Autor:
Manthena V.S. Varma, Ravi Visswanathan, David A. Tess, Caitlin Jagla, George Chang, JianHua Liu, Rhys M. Jones, Christopher Keefer, Li Di, John P. Umland, Nathaniel Johnson, Heather Eng, Michael J. Banker, R. Scott Obach, Keith Riccardi, Jillian Racich, Samantha Jordan, Anthony Carlo, Jonathan J. Novak, Jackie Carey, Julie Cianfrogna, Sarah Lazzaro
Publikováno v:
European Journal of Pharmaceutical Sciences. 155:105541
Human liver microsomes (HLM) and human hepatocytes (HHEP) are two common in vitro systems used in metabolic stability and inhibition studies. The comparison between the assays using the two systems can provide mechanistic insights on the interplay of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c8e4dbb8b1e6762283954eceaec97c
https://doi.org/10.1016/j.ejps.2020.105541
https://doi.org/10.1016/j.ejps.2020.105541
Autor:
Rama Y. Chandrasekaran, Jiri Aubrecht, Frederick R. Nelson, Linda A. Chatman, Hans Rollema, Frank M. Nedza, John M. Marcek, Philip A. Iredale, Jennifer B. Munzner, Betty Pettersen, Raggon Jeffrey W, David M. Rubitski, Julie Cianfrogna, Larry C. James, Karen W. Cook, Michael J. Banker, Diane F. Wong, Anne W. Schmidt, Michael Homiski, Howard Harry R, Daniel J. Lettiere, Butler Todd W, Scot Richard Mente, Jody Freeman, Travis T. Wager, Douglas K. Spracklin
Publikováno v:
Journal of Medicinal Chemistry. 54:7602-7620
The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c253ef2a0b55c8bf1f6522eccc0c6ed
https://doi.org/10.1021/jm200939b
https://doi.org/10.1021/jm200939b
Publikováno v:
Journal of Law, Medicine & Ethics. 37:732-748
Societal evaluation of new technologies, specifically nanotechnology and genetically engineered organisms (GEOs), challenges current practices of governance and science. Employing environmental risk assessment (ERA) for governance and oversight assum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c1db753deb069752d3d11651f32bcf
https://doi.org/10.1111/j.1748-720x.2009.00444.x
https://doi.org/10.1111/j.1748-720x.2009.00444.x
Autor:
Travis T, Wager, Betty A, Pettersen, Anne W, Schmidt, Douglas K, Spracklin, Scot, Mente, Todd W, Butler, Harry, Howard, Daniel J, Lettiere, David M, Rubitski, Diane F, Wong, Frank M, Nedza, Frederick R, Nelson, Hans, Rollema, Jeffrey W, Raggon, Jiri, Aubrecht, Jody K, Freeman, John M, Marcek, Julie, Cianfrogna, Karen W, Cook, Larry C, James, Linda A, Chatman, Philip A, Iredale, Michael J, Banker, Michael L, Homiski, Jennifer B, Munzner, Rama Y, Chandrasekaran
Publikováno v:
Journal of medicinal chemistry. 54(21)
The discovery of two histamine H(3) antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success in id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2437f9ba9156d813302f64ee16a8582b
https://pubmed.ncbi.nlm.nih.gov/21928839
https://pubmed.ncbi.nlm.nih.gov/21928839
Autor:
Michael J. Banker, Tracey Clark
Publikováno v:
Current drug metabolism. 9(9)
The binding of a drug to serum or plasma proteins enables the transport of drugs via the blood to sites of action throughout the body. For expediency we will use serum proteins throughout this discussion with the understanding that one can substitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686a113b267e8979ceb137f55816de44
https://pubmed.ncbi.nlm.nih.gov/18991581
https://pubmed.ncbi.nlm.nih.gov/18991581
Publikováno v:
Nature Biotechnology. 7:1271-1274
Enhanced Expression of an Immunoglobulin-Based Vector in Myeloma Cells Mediated by Coamplification with a Mutant Dihydrofolate Reductase Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3626a59cf13c03796158d335f3729da6
https://doi.org/10.1038/nbt1289-1271
https://doi.org/10.1038/nbt1289-1271
Publikováno v:
Gene. 64:43-51
We have constructed a high-efficiency vector for expression of genes of interest in myeloma cells. This vector is comprised of regulatory sequences from immunoglobulin (Ig) genes, including the heavy-chain enhancer, a k light-chain promoter and splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d343595e6d79d7986af70aa62f62e9
https://doi.org/10.1016/0378-1119(88)90479-9
https://doi.org/10.1016/0378-1119(88)90479-9