Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael I. Webb"'
Autor:
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Publikováno v:
Dalton Transactions. 51:17609-17619
The evolution of high virulence bacterial strains has necessitated the development of novel therapeutic agents to treat resistant infections. Metal-based therapeutics represent a promising avenue for advancement, given their structural variability an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1546fc3ff34622aceacaf1d054334c4
https://doi.org/10.1039/d2dt02696a
https://doi.org/10.1039/d2dt02696a
Publikováno v:
Canadian Journal of Chemistry. 100:18-24
Recent recognition of the soluble form of the amyloid-beta (Aβ) peptide as a neurotoxic agent in Alzheimer’s disease (AD) has spurred the development of agents to target this species. Because Aβ is known to chelate metal ions in solution, metal-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2004fb4bb551b06168d1236a252bab4
https://doi.org/10.1139/cjc-2021-0180
https://doi.org/10.1139/cjc-2021-0180
Autor:
Marjorie A. Jones, David C. Platt, Samantha E. Huffman, Paige J. Bothwell, Samuel S. Fisher, Michael I. Webb, Gideon K. Yawson, Christopher G. Hamaker
Publikováno v:
Metallomics. 12:491-503
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ). These deposits contain a high concentration of metals and init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e25af24dfcf19e605c684f89164853
https://doi.org/10.1039/d0mt00054j
https://doi.org/10.1039/d0mt00054j
Autor:
Gideon K. Yawson, Mark F. Will, Samantha E. Huffman, Evan T. Strandquist, Paige J. Bothwell, Ethan B. Oliver, C. Fiore Apuzzo, David C. Platt, Christopher S. Weitzel, Marjorie A. Jones, Gregory M. Ferrence, Christopher G. Hamaker, Michael I. Webb
Publikováno v:
Inorganic chemistry. 61(6)
Alzheimer's disease (AD) is a devastating neurological disorder for which soluble oligomers of the peptide amyloid-β (Aβ) are now recognized as the neurotoxic species. Metal-based therapeutics are uniquely suited to target Aβ, with ruthenium-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1362f0c5c0ca11851c98002368aae43
https://pubmed.ncbi.nlm.nih.gov/35102739
https://pubmed.ncbi.nlm.nih.gov/35102739
Autor:
Mark F. Will, Marjorie A. Jones, Brendan J. Wall, Gideon K. Yawson, Paige J. Bothwell, David C. Platt, Michael I. Webb, Gregory M. Ferrence, C. Fiore Apuzzo
Publikováno v:
Journal of medicinal chemistry. 64(14)
Alzheimer's disease (AD) is the most common form of dementia, where one of the pathological hallmarks of AD is extracellular protein deposits, the primary component of which is the peptide amyloid-β (Aβ). Recently, the soluble form of Aβ has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5709715f2d5c888731c8f7803fc05e85
https://pubmed.ncbi.nlm.nih.gov/34197109
https://pubmed.ncbi.nlm.nih.gov/34197109
Autor:
Ryan M. Clarke, Tim Storr, S. Esmael Balaghi, Didier Savard, Edwin W. Y. Wong, Elham Safaei, Linus Chiang, Diego Martelino, Michael I. Webb, Charles J. Walsby
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 48(35)
A tridentate benzoxazole-containing aminophenol ligand NNOH2 was coordinated to Co and V metal centers and the electronic structure of the resultant complexes characterized by both experimental and theoretical methods. The solid state structure of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb228103fe75ec5285b32d3d56bda8d
https://pubmed.ncbi.nlm.nih.gov/31429839
https://pubmed.ncbi.nlm.nih.gov/31429839
Autor:
Samuel S. Fisher, Gideon K. Yawson, Paige J. Bothwell, Michael I. Webb, Christopher G. Hamaker, Samantha E. Huffman, David C. Platt, Gregory M. Ferrence, Marjorie A. Jones
Publikováno v:
Journal of Inorganic Biochemistry. 214:111303
Alzheimer's disease (AD) is the most common form of dementia, characterized by extracellular protein deposits, comprised primarily of the peptide amyloid-beta (Aβ), are a pathological indicator of the disease. Commonly known as Aβ plaques, these de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2645039c24d9bad6e406fb6df75cf2ab
https://doi.org/10.1016/j.jinorgbio.2020.111303
https://doi.org/10.1016/j.jinorgbio.2020.111303
Autor:
Charles J. Walsby, Michael I. Webb
Publikováno v:
Dalton Transactions. 44:17482-17493
The ruthenium anticancer compound NAMI-A, imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)], is currently undergoing advanced clinical evaluation. As with other Ru(iii) chemotherapeutic candidates, interactions with human serum albumin (HSA) have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee773e2752a998863613d28cce607f7
https://doi.org/10.1039/c5dt02021b
https://doi.org/10.1039/c5dt02021b
Increasing the Bioavailability of RuIIIAnticancer Complexes through Hydrophobic Albumin Interactions
Autor:
Edwin W. Y. Wong, Donald T. T. Yapp, Thalia Jang, Boris Wu, Charles J. Walsby, Ryan A. Chard, Michael I. Webb, May Q. Wong
Publikováno v:
Chemistry - A European Journal. 19:17031-17042
A series of pyridine-based derivatives of the clinically successful Ru(III)-based complexes indazolium [trans-RuCl4(1H-indazole)2] (KP1019) and sodium [trans-RuCl4(1H-indazole)2] (KP1339) have been synthesized to probe the effect of hydrophobic inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c0e8bb5dfbf37393be365419cfe8d0
https://doi.org/10.1002/chem.201302671
https://doi.org/10.1002/chem.201302671
Autor:
Nathan R. Halcovitch, Christopher M. Vogels, Michael J. Geier, Christopher A. Gray, Andreas Decken, Taryn O'Neill, Andrew J. Flewelling, Eric G. Bowes, Michael I. Webb, Graham M. Lee, Haoxin Li, Stephen A. Westcott
Publikováno v:
Journal of Heterocyclic Chemistry. 51:157-161
A family of arylspiroborates has been prepared by the addition of either 4-tert-butylcatechol or 3,5-di-tert-butylcatechol to boric acid and an alkali metal hydroxide. All compounds were characterized fully using multinuclear NMR spectroscopy and by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710aa4f0e81a45774d1a8a878494e47a
https://doi.org/10.1002/jhet.1997
https://doi.org/10.1002/jhet.1997