Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Michael I. Sherman"'
Autor:
Alexandra Zablotny, Gregory Glass, Andre Hackman, Yun Sang Cheah, Joel Gittelsohn, Hannah Lee Coakley, Michael I Sherman, Yeeli Mui, Elizabeth Anderson Steeves
Publikováno v:
The FASEB Journal. 27
Publikováno v:
Medicinal Research Reviews. 15:277-298
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:469-475
Oligonucleotides are ideal compounds to use for high-throughput screening. This article describes techniques by which oligonucleotides with potential therapeutic activity can be identified and chemically modified to serve as drugs.
Publikováno v:
ChemInform. 26
Autor:
Ming-Chu Hsu, Douglas D. Richman, Mary Jane Potash, Lee W. Slice, David J. Volsky, Andrew D. Schutt, Maureen Holly, Michael I. Sherman
Publikováno v:
Science. 254:1799-1802
The human immunodeficiency virus-1 (HIV-1) trans-activator Tat is an attractive target for the development of antiviral drugs because inhibition of Tat would arrest the virus at an early stage. The drug Ro 5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodi
Autor:
Mary I. Harper, Patricio Abarzua, Shencao Tan, Michael I. Sherman, Simonetta Astigiano, Uriel Barkai
Publikováno v:
Differentiation. 46:61-67
cDNA libraries have been generated from Nulli-SCCl murine embryonal carcinoma (EC) cells untreated or treated for 24 h with all-trans retinoic acid (RA) or hexamethylenebisacetamide (HMBA), two chemically unrelated inducers of differentiation of EC c
Autor:
Mary Lou Gubler, Uriel Barkai, Jeffrey Yuan, Mary I. Harper, George R. Coppola, Michael I. Sherman
Publikováno v:
Ciba Foundation Symposium 113-Retinoids, Differentiation and Disease
To study how retinoids promote differentiation and inhibit proliferation of embryonal carcinoma (EC) cells, we have followed their intracellular fate. Retinoic acid (RA) is effectively metabolized to more polar compounds by many EC lines. Unlike RA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c652db84944dc0ac384290fb4abcb7
https://doi.org/10.1002/9780470720943.ch4
https://doi.org/10.1002/9780470720943.ch4
Publikováno v:
Ciba Foundation Symposium 64-Maternal Recognition of Pregnancy
Implantation is a critical event, and perhaps the earliest one, in the maternal recognition of pregnancy. Information transfer from conceptus to mother might occur during, and subsequent to, implantation at the level of cell surface interaction. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9490f88efdf4aed1485b48b183e52ea
https://doi.org/10.1002/9780470720479.ch3
https://doi.org/10.1002/9780470720479.ch3
Publikováno v:
Current opinion in biotechnology. 7(6)
The p53 tumor suppressor gene is a logical target for cancer therapy. Several therapeutic strategies can be envisioned based upon recent advances concerning structure and function of the p53 protein, its interaction with cellular and viral proteins a
Publikováno v:
Bio/technology (Nature Publishing Company). 13(2)
Should therapy be aimed at restoring normal phenotype to cancer cells or at eliminating the cells altogether?