Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael I. Robson"'
Autor:
Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas
Externí odkaz:
https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
Autor:
Nicholas C Lister, Ashley M Milton, Hardip R Patel, Shafagh A Waters, Benjamin J Hanrahan, Kim L McIntyre, Alexandra M Livernois, Lee Kian Wee, Alessa R. Ringel, Stefan Mundlos, Michael I. Robson, Linda Shearwin-Whyatt, Frank Grützner, Jennifer A. Marshall Graves, Aurora Ruiz-Herrera, Paul D Waters
Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between the sexes, and with the autosomes. Mammalian X chromosome inactivation was long thought to imply a critical need for dosage compensation in vertebrates. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d2dc554b73283a391d6e7c4fcf82bbf
https://doi.org/10.1101/2023.02.23.529605
https://doi.org/10.1101/2023.02.23.529605
Autor:
Alessa R. Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Juliane Glaser, Mai H.Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, Christina Paliou, Andrea Esposito, Cesar A. Prada-Medina, Stefan A. Haas, Peter Giere, Martin Vingron, Lars Wittler, Alexander Meissner, Mario Nicodemi, Giacomo Cavalli, Frédéric Bantignies, Stefan Mundlos, Michael I. Robson
Publikováno v:
Cell
Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, Zfp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e9142d1b2b33cf90aa22817b71f0ee
https://hdl.handle.net/11588/902575
https://hdl.handle.net/11588/902575
Autor:
Quentin Szabo, M. Phan, Giacomo Cavalli, Cesar Augusto Prada-Medina, Christina Paliou, Sara Hetzel, Michael I. Robson, K. Chudzik, Andrea M. Chiariello, Stephan Haas, Tobias Zehnder, Daniel M. Ibrahim, Alexander Meissner, Andrea Esposito, R. Schoepflin, P. Giere, P. Rothe, Simona Bianco, Martin Vingron, V. Laupert, Dermot Harnett, Stefan Mundlos, Frédéric Bantignies, Alessa R. Ringel, Lars Wittler, Alexandra L. Mattei, Mario Nicodemi, Magdalena Schindler
Publikováno v:
bioRxiv
SUMMARYCohesin loop extrusion facilitates precise gene expression by continuously driving promoters to sample all enhancers located within the same topologically-associated domain (TAD). However, many TADs contain multiple genes with divergent expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4599ee2b7ed6fc682687ac1ce79055ae
https://doi.org/10.1101/2021.10.08.463672
https://doi.org/10.1101/2021.10.08.463672
Autor:
Malte Spielmann, Michael I. Robson, Diederik R.H. de Bruijn, Bjørn Ivar Haukanes, Gunnar Houge, Siren Berland, Aaron Jeffries, Stefan Mundlos, Nicole de Leeuw, Jayne Y. Hehir-Kwa, Helle Lybæk
BackgroundLRFN5 is a brain-specific gene needed for synaptic development and plasticity. It is the only gene in a large 5.4 Mb topologically associating domain (TAD) on chromosome 14, which we term the LRFN5 locus. This locus is highly conserved, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50730dbd07e8b8145e6d4f6cb2156df5
https://doi.org/10.21203/rs.3.rs-895724/v1
https://doi.org/10.21203/rs.3.rs-895724/v1
Autor:
Edda G. Schulz, Robert Schöpflin, Michael I. Robson, Schmiedel, Evgenia Ntini, Brandenburg L, Lustig Lr, Mutzel, Stefan Mundlos, Ilona Dunkel, Kautz P, Annalisa Marsico, Vechiatto C, Rutger A. F. Gjaltema, Schwämmle T
Developmental genes such asXist, the master regulator of X-chromosome inactivation (XCI), are controlled by complexcis-regulatory landscapes, which decode multiple signals to establish specific spatio-temporal expression patterns.Xistintegrates infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0beb678a8a4c0a9edabe5b8d7d3c5c9f
https://doi.org/10.1101/2021.03.29.437476
https://doi.org/10.1101/2021.03.29.437476
Autor:
Rosanna Pescini-Gobert, Luciano Farage, Mathieu Quinodoz, Stefan Mundlos, Srilakshmi Rajagopal, Andreas Magg, Sara Balzano, Phillip Grote, Wing Lee Chan, Alessa R. Ringel, Daniel R. Carvalho, Malte Spielmann, Sheila Unger, Belinda Campos-Xavier, Giulia Cova, Regina Albuquerque, Beryl Royer-Bertrand, Florence Niel-Bütschi, Sheela Nampoothiri, Michael I. Robson, Charles Marques Lourenço, Bernd Timmermann, Guillaume Andrey, Carlo Rivolta, Carlos E. Speck-Martins, Lars Wittler, Verena Heinrich, Cesar Augusto Prada-Medina, Luisa Bonafé, Andrea Superti-Furga, Lila Allou, Robert Schöpflin, Carole Chiesa
Publikováno v:
Nature (2021)
Nature
Nature
Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory networks1, but the exact nature and extent of their involvement in human Mendelian disease is largely unknown. Here we show that genetic ablation of a lncRNA locus on human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97517091f766d74245c65c68bee42eaa
https://archive-ouverte.unige.ch/unige:149472
https://archive-ouverte.unige.ch/unige:149472
Autor:
Andrea Jurisicova, Yonit Tsatskis, Rod Bremner, John R. B. Perry, Kyunga Kim, Brian Ciruna, Daniel Potter, Dorothea Godt, Wade H. Dunham, Yu Sun, Michael I. Robson, Shu Wu, Robyn Rosenfeld, Julie A. Brill, Karen Krchma, Tim Schedl, Anne-Claude Gingras, Joel Pearson, Curtis W. Boswell, Helen McNeill, Kyunghee Choi, Laurence Pelletier, Didier Hodzic, Jin Meng, Lacramioara Fabian, Yi Qu, Ariz Mohammad, Eric C. Schirmer, João Gonçalves, Jun Wu, Xian Wang
Publikováno v:
Science Advances
Tsatskis, Y, Rosenfeld, R, Pearson, J D, Boswell, C, Qu, Y, Kim, K, Fabian, L, Mohammed, A, Wang, X, Robson, M, Krchma, K, Wu, J, Gonçalves, J, Hodzic, D, Wu, S, Potter, D, Pelletier, L, Dunham, W H, Gingras, A-C, Sun, Y, Meng, J, Godt, D, Schedl, T, Ciruna, B, Choi, K, Perry, J R B, Bremner, R, Schirmer, E C, Brill, J A, Jurisicova, A & McNeill, H 2020, ' The NEMP family supports metazoan fertility and nuclear envelope stiffness ', Science Advances, vol. 6, eabb4591 . https://doi.org/10.1126/sciadv.abb4591
Tsatskis, Y, Rosenfeld, R, Pearson, J D, Boswell, C, Qu, Y, Kim, K, Fabian, L, Mohammed, A, Wang, X, Robson, M, Krchma, K, Wu, J, Gonçalves, J, Hodzic, D, Wu, S, Potter, D, Pelletier, L, Dunham, W H, Gingras, A-C, Sun, Y, Meng, J, Godt, D, Schedl, T, Ciruna, B, Choi, K, Perry, J R B, Bremner, R, Schirmer, E C, Brill, J A, Jurisicova, A & McNeill, H 2020, ' The NEMP family supports metazoan fertility and nuclear envelope stiffness ', Science Advances, vol. 6, eabb4591 . https://doi.org/10.1126/sciadv.abb4591
Loss of Nemp leads to softening of the germline nuclear envelope and loss of fertility.
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause;
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526b5f096f3c9b8dfa6e5d0b8a6b78dd
Autor:
Konstantin Helmsauer, Matthias Fischer, David Torrents, M. E. Valieva, Philipp Euskirchen, F Hertwig, Katharina Kasack, Claudia Röefzaad, Heathcliff Dorado Garcia, Rocío Chamorro González, Luis P. Kuschel, Robert Schöpflin, Kerstin Haase, Stefan Mundlos, Angelika Eggert, Anton G. Henssen, Verena Heinrich, Yi Bei, Johannes Schulte, Richard Koche, Michael I. Robson, Elias Rodriguez-Fos, Montserrat Puiggròs, Carolina Rosswog, Annabell Szymansky, Salaheddine Ali, Jörn Tödling
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA. The exact amplicon structure has not been described thus far and the functional relevan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9711a48d996498abf07dbc3f6d695
Publikováno v:
Molecular cell. 74(6)
During embryogenesis, precise gene transcription in space and time requires that distal enhancers and promoters communicate by physical proximity within gene regulatory landscapes. To achieve this, regulatory landscapes fold in nuclear space, creatin