Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael I. Nerenberg"'
Publikováno v:
Journal of Neuroimmunology
Astrocytes provide crucial support for neurons and their impairment by viruses or their interactions with anti-viral or autoimmune responses could contribute to neurological disease. We have developed a transgenic mouse model to assess lymphocyte-ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c025c333a56e7f273dd0a8329749f3
http://europepmc.org/articles/PMC7119529
http://europepmc.org/articles/PMC7119529
Publikováno v:
Inflammation. 23:583-590
Oligonucleotide N3′ → P5′ Phosphoramidates (PN) may confer advantages over unmodified phosphodiester compounds for therapeutic applications (1). Previous in vitro data demonstrated that PN Oligodeoxynucleotides (ODNs) possess several advantageo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5f7937ba477c49a179450d5dd8f570
https://doi.org/10.1023/a:1020298608675
https://doi.org/10.1023/a:1020298608675
Publikováno v:
AIDS Research and Human Retroviruses. 12:829-832
Genomic footprinting of integrated HTLV-I and HIV-1 confirmed many aspects of retroviral transcriptional regulation deduced from previous studies. However, many notable differences were seen. HTLV-I genomic protein-binding patterns corresponded more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fff634ac3bd5caaaa91154da56896a
https://doi.org/10.1089/aid.1996.12.829
https://doi.org/10.1089/aid.1996.12.829
Publikováno v:
Human Gene Therapy. 7:471-477
Human T cell leukemia virus type 1 (HTLV-1) causes adult T cell leukemia (ATL), and the virus-encoded trans-activator, Tax, plays an important role in T cell transformation. In the HTLV-1 long terminal repeat (LTR)-Tax transgenic mouse model, Tax exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd1e28c327cba81675f957e4a843865
https://doi.org/10.1089/hum.1996.7.4-471
https://doi.org/10.1089/hum.1996.7.4-471
Autor:
Xiao Xu, David Brown, Shin-Heh Kang, Olaf Heidenreich, Sergei M. Gryaznov, Isao Kitajima, Michael I. Nerenberg
Publikováno v:
Journal of Biological Chemistry. 271:7330-7335
The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be4464cc392d94a0cc236e4d718e239
https://doi.org/10.1074/jbc.271.13.7330
https://doi.org/10.1074/jbc.271.13.7330
Publikováno v:
Scopus-Elsevier
A chemically modified hammerhead ribozyme was designed to cleave the tax RNA of human T cell leukemia virus type I. This ribozyme was exogenously delivered to tax-transformed fibroblasts by DOTAP-mediated transfection. The analysis of RNA from ribozy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadc69146e0e558a8e197ffe2775f97a
https://doi.org/10.1089/oli.1.1996.6.141
https://doi.org/10.1089/oli.1.1996.6.141
Publikováno v:
Journal of Neurovirology. 2:60-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904050715579d1fec87449d07efeeee1
https://doi.org/10.3109/13550289609146539
https://doi.org/10.3109/13550289609146539
Publikováno v:
Journal of Clinical Investigation. 96:1548-1555
HTLV-1 infection causes an adult T cell leukemia in humans. The viral encoded protein tax, is thought to play an important role in oncogenesis. Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec03d7e2eda7508df5e45264b93a8c90
https://doi.org/10.1172/jci118193
https://doi.org/10.1172/jci118193
Publikováno v:
Scopus-Elsevier
Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd731bb07fe30b20c0848d1e2163f222
https://doi.org/10.1016/s1357-4310(95)80090-5
https://doi.org/10.1016/s1357-4310(95)80090-5
Autor:
Fritz Eckstein, Olaf Heidenreich, Michael I. Nerenberg, John J. Rossi, Shin-Heh Kang, Piotr Swiderski, Xiao Xu, David A. Brown
Publikováno v:
Scopus-Elsevier
Ribozymes containing 2'-fluoro- and 2'-amino-modified pyrimidine nucleosides in combination with terminal phosphorothioate linkages were targeted against HTLV-I tax RNA. In order to examine the activity of such chemically modified ribozymes in the nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feb11492b8a081692bc6f87c9148b49
https://doi.org/10.1093/nar/23.12.2223
https://doi.org/10.1093/nar/23.12.2223