Výsledky vyhledávání - "Michael I. Anazodo"

Characterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication

Autor: Albert D. Friesen, Elena Duta, Michael I. Anazodo, Jim A. Wright, Mark A. Wainberg, Horacio Salomon

Publikováno v: Nucleosides and Nucleotides. 16:1241-1249

Fully thioated antisense molecules are often cytotoxic and non-specitic in action. GPI2A is thioated at 7 base positions. GPI2A posses sequence-specific activity against HIV-1 gene expression and viral replication without sigdcant cytotoxicity. Parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2be7961dbb3f77d2bc545cca6d7c212
https://doi.org/10.1080/07328319708006166

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Relative levels of inhibition of p24 gene expression by different 20-mer antisense oligonucleotide sequences targeting nucleotides + 1129 to + 1268 of the HIV-1 gag genome: an analysis of mechanism

Autor: Elena Duta, Jim A. Wright, Michael I. Anazodo, Albert D. Friesen

Publikováno v: Biochemical and biophysical research communications. 229(1)

GPI2A is a 20-mer antisense oligonucleotide sequence that is complementary to a region of the HIV-1gaggene. An analysis of viral core antigen p24 protein synthesis inhibition was performed with cells expressing HIV-1 proteins, following treatment wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3881f52a6172e1207c153fc6009a4b23
https://pubmed.ncbi.nlm.nih.gov/8954123

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Sequence-specific inhibition of gene expression by a novel antisense oligodeoxynucleotide phosphorothioate directed against a nonregulatory region of the human immunodeficiency virus type 1 genome

Autor: Michael I. Anazodo, Jim A. Wright, A D Friesen, M A Wainberg

Previous studies have demonstrated that oligodeoxynucleotide phosphorothioates complementary to human immunodeficiency virus type 1 (HIV-1) RNA are more nuclease resistant and are effective inhibitors of HIV-1 replication than their unmodified counte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cb3c8b7a596f233ee1c65601950eba
https://europepmc.org/articles/PMC188787/

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Calmodulin- and Ca2(+)-insensitive fatty acid methyltransferase from RINm5F cells. Inhibition by trifluoperazine and W7

Autor: Michael I. Anazodo, Hasan Safayhi, Hermann P. T. Ammon

Publikováno v: The International journal of biochemistry. 23(7-8)

1. 1. Methylation of endogenous lipids by homogenates of rat insulinoma cells was studied. 2. 2. 3 H-methyl groups (38pmol/mg protein per 10min) from [ 3 H-methyl ]S- adenosyl - l - methionine were incorporated into endogenous lipids, mainly (> 80%)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470a22b5adc1d9b1e22230967c3d962e
https://pubmed.ncbi.nlm.nih.gov/1907579

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Pharmacokinetic properties and toxicological studies of GPI2A, a gene expression modulator and a potent antiviral agent against HIV-1 virus

Autor: Michael I. Anazodo, Elena Duta, M. Wamberg, Albert D. Friesen, Caiqiong Liu, C. Power, Jim A. Wright

Publikováno v: Antiviral Research. 34:A63

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1d0cc58adf76dda4d9bc7e8512d860f
https://doi.org/10.1016/s0166-3542(97)83215-9

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