Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Michael I Love"'
Autor:
Min-Zhi Jiang, François Aguet, Kristin Ardlie, Jiawen Chen, Elaine Cornell, Dan Cruz, Peter Durda, Stacey B Gabriel, Robert E Gerszten, Xiuqing Guo, Craig W Johnson, Silva Kasela, Leslie A Lange, Tuuli Lappalainen, Yongmei Liu, Alex P Reiner, Josh Smith, Tamar Sofer, Kent D Taylor, Russell P Tracy, David J VanDenBerg, James G Wilson, Stephen S Rich, Jerome I Rotter, Michael I Love, Laura M Raffield, Yun Li, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010517 (2023)
Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological system of interest. Canonical correlation analysis (C
Externí odkaz:
https://doaj.org/article/98cb75bd5fb04c1883187221a94d546b
Autor:
Hannah J Perrin, Kevin W Currin, Swarooparani Vadlamudi, Gautam K Pandey, Kenneth K Ng, Martin Wabitsch, Markku Laakso, Michael I Love, Karen L Mohlke
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009865 (2021)
Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity acro
Externí odkaz:
https://doaj.org/article/92bcda09d29846e985b1f396bf252601
Autor:
Anqi Zhu, Nana Matoba, Emma P Wilson, Amanda L Tapia, Yun Li, Joseph G Ibrahim, Jason L Stein, Michael I Love
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009455 (2021)
Expression quantitative trait loci (eQTL) studies are used to understand the regulatory function of non-coding genome-wide association study (GWAS) risk loci, but colocalization alone does not demonstrate a causal relationship of gene expression affe
Externí odkaz:
https://doaj.org/article/80a5b34ef72a4f9885b9442237f0bd45
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009398 (2021)
Traditional predictive models for transcriptome-wide association studies (TWAS) consider only single nucleotide polymorphisms (SNPs) local to genes of interest and perform parameter shrinkage with a regularization process. These approaches ignore the
Externí odkaz:
https://doaj.org/article/94734598cb2d4bf2a8bd614f5b5b12a0
Autor:
Michael I Love, Charlotte Soneson, Peter F Hickey, Lisa K Johnson, N Tessa Pierce, Lori Shepherd, Martin Morgan, Rob Patro
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007664 (2020)
Correct annotation metadata is critical for reproducible and accurate RNA-seq analysis. When files are shared publicly or among collaborators with incorrect or missing annotation metadata, it becomes difficult or impossible to reproduce bioinformatic
Externí odkaz:
https://doaj.org/article/da9cc4aebd6e4be7bcb1f88ca81d32c9
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006372 (2018)
Cell-type specific gene expression is regulated by the combinatorial action of transcription factors (TFs). In this study, we predict transcription factor (TF) combinations that cooperatively bind in a cell-type specific manner. We first divide DNase
Externí odkaz:
https://doaj.org/article/33b59fba6a4243fb9093c8fc268a1551
Publikováno v:
HGG Advances, Vol 5, Iss 4, Pp 100348- (2024)
Summary: Identifying causal genes underlying genome-wide association studies (GWASs) is a fundamental problem in human genetics. Although colocalization with gene expression quantitative trait loci (eQTLs) is often used to prioritize GWAS target gene
Externí odkaz:
https://doaj.org/article/563ae9b155174a34a141d7ee3460a524
Autor:
Alina M. Hamilton, Sarah C. Van Alsten, Xiaohua Gao, Joseph Nsonwu-Farley, Benjamin C. Calhoun, Michael I. Love, Melissa A. Troester, Katherine A. Hoadley
Publikováno v:
Cancer Research Communications. 3:12-20
Markers of genomic instability, including TP53 status and homologous recombination deficiency (HRD), are candidate biomarkers of immunogenicity and immune-mediated survival, but little is known about the distribution of these markers in large, popula
Publikováno v:
Human Molecular Genetics. 32:402-416
Genomic imprinting results in gene expression bias caused by parental chromosome of origin and occurs in genes with important roles during human brain development. However, the cell-type and temporal specificity of imprinting during human neurogenesi
Autor:
Melissa A. Troester, Katherine A. Hoadley, Cyrus Vaziri, Charles M. Perou, Gaorav P. Gupta, Michael I. Love, Erin L. Kirk, Alina M. Hamilton, Xiaohua Gao, Alex Lockhart, Markia A. Smith, Linnea T. Olsson, Sarah C. Van Alsten, Andrea Walens
Background:Aberrant expression of DNA repair pathways such as homologous recombination (HR) can lead to DNA repair imbalance, genomic instability, and altered chemotherapy response. DNA repair imbalance may predict prognosis, but variation in DNA rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26082be2ddd4e39d8e04cca6b3b9f150
https://doi.org/10.1158/1055-9965.c.6660312.v1
https://doi.org/10.1158/1055-9965.c.6660312.v1