Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael I Lethem"'
Autor:
Yunxiang Zhu, Lubna H Abdullah, Sean P Doyle, Kristine Nguyen, Carla M P Ribeiro, Paula A Vasquez, M Gregory Forest, Michael I Lethem, Burton F Dickey, C William Davis
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127267 (2015)
Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds
Externí odkaz:
https://doaj.org/article/23c76bc6f5944e9f97db43bcc1a2d973
Publikováno v:
International journal of pharmaceutics. 608
Hypersecretion of mucus is associated with impaired mucociliary clearance that can influence the retention of active pharmaceutical ingredients in the airway but is also linked with recurrent airway disease. Therefore, the effect on mucin secretion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d8757fbce85c71641d764f7cbf0d0f
https://pubmed.ncbi.nlm.nih.gov/34461170
https://pubmed.ncbi.nlm.nih.gov/34461170
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 24:602-609
Ovine airway epithelial explants, cultured at an air-liquid interface, were used to determine whether endothelin (ET-1) acts via ET(A)- or ET(B)-receptors to increase ciliary beat frequency (CBF). Further, the role of prostanoids and nitric oxide (NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afde77fffc79273ab42f73d3fc194aca
https://doi.org/10.1016/j.pupt.2011.05.008
https://doi.org/10.1016/j.pupt.2011.05.008
Autor:
Michael I. Lethem, Lubna H. Abdullah, Yunxiang Zhu, Sean P. Doyle, M. Gregory Forest, Paula A. Vasquez, Burton F. Dickey, C. William Davis, Carla Ribeiro, Kristine Nguyen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 5, p e0127267 (2015)
PLoS ONE, Vol 10, Iss 5, p e0127267 (2015)
Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef151befd3b1a1a98fd4fc95e5d0b389
Expression of nucleotide-regulated Cl−currents in CF and normal mouse tracheal epithelial cell lines
Publikováno v:
American Journal of Physiology-Cell Physiology. 279:C1578-C1586
The dominant route for Cl−secretion in mouse tracheal epithelium is via Cl−channels different from the cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the channel that is defective in CF. It has been proposed that the use of puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ab63384b724dc4dd7f526baa7bfdd7
https://doi.org/10.1152/ajpcell.2000.279.5.c1578
https://doi.org/10.1152/ajpcell.2000.279.5.c1578
Autor:
Michael I. Lethem
Publikováno v:
Advanced Drug Delivery Reviews. 11:271-298
For drug delivery to the airways to be effective the protective mechanisms of the lung must be overcome so that the drug can reach its site of action. Airway mucus is an integral part of these mechanisms and as such can have profound effects on drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e1cf373fc57992bc49473f5976618a
https://doi.org/10.1016/0169-409x(93)90013-t
https://doi.org/10.1016/0169-409x(93)90013-t
Autor:
Robert Combes, JeanClare Seagrave, Jean-Paul Morin, Michael Kelly, Marianna Gaça, Manfred Liebsch, Alison C Gray, Leona Merolla, Rodger Duffin, Melody A. Swartz, Kelly Ann Berube, Ian P. Hall, Michael I. Lethem, Teresa D. Tetley, Ben Forbes, Richard H. Clothier, Michaela Aufderheide, Damien Breheny, Meera Umachandran
Publikováno v:
Scopus-Elsevier
The aim of research in the FRAME Alternatives Laboratory at the University of Nottingham Medical School is summarised, i.e. to use human cell culture-based projects and in vivo studies in human volunteers as alternatives to the use of rodent models i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976dc25a8ec3d9801abab979ae864976
https://pubmed.ncbi.nlm.nih.gov/20105019
https://pubmed.ncbi.nlm.nih.gov/20105019
Autor:
Scott H. Donaldson, Andrew J. Hirsh, Ray D. Coakley, Mark T. Clunes, Mellisa Burn, Michael I. Lethem, Brett M. Rollins, Robert Tarran, Lucy A. Chambers
Publikováno v:
American journal of respiratory cell and molecular biology. 39(2)
Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary disease, and the A(2B) adenosine receptor (A(2B)-R) may drive pulmonary inflammation. Accordingly, it has been proposed that specific inhibition of the A(2B)-R coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928f67ee37c90ba57ff82f0a514e6a50
https://pubmed.ncbi.nlm.nih.gov/18367727
https://pubmed.ncbi.nlm.nih.gov/18367727
Publikováno v:
Biosensorsbioelectronics. 23(8)
Recent applications of quartz crystal resonant sensor technology to monitor cell adhesion and specific ligand interaction processes has triggered the development of a new category of quartz crystal microbalance (QCM) based biosensors. In this study h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12580b161f9790a345816d15c1e194d1
https://pubmed.ncbi.nlm.nih.gov/18207383
https://pubmed.ncbi.nlm.nih.gov/18207383
Autor:
Udo Schumacher, Michael I. Lethem, Michael Yeadon, Elizabeth Adam, Mark Yeoman, Sinead M. Clancy, John Parry
Publikováno v:
American journal of respiratory cell and molecular biology. 31(6)
Mucus hypersecretion is a feature of several respiratory diseases and frequently leads to obstruction of small airways where the principal source of mucous glycoproteins (mucins), the major macromolecular constituents of mucus, are goblet cells. Henc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43dca98b0dfe434bdbe612839ee944d
https://pubmed.ncbi.nlm.nih.gov/15347558
https://pubmed.ncbi.nlm.nih.gov/15347558