Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Michael I Dorrell"'
Autor:
Michael I Dorrell, Heidi R Kast-Woelbern, Ryan T Botts, Stephen A Bravo, Jacob R Tremblay, Sarah Giles, Jessica F Wada, MaryAnn Alexander, Eric Garcia, Gabriel Villegas, Caylor B Booth, Kaitlyn J Purington, Haylie M Everett, Erik N Siles, Michael Wheelock, Jordan A Silva, Bridget M Fortin, Connor A Lowey, Allison L Hale, Troy L Kurz, Jack C Rusing, Dawn M Goral, Paul Thompson, Alec M Johnson, Daniel J Elson, Roujih Tadros, Charisa E Gillette, Carley Coopwood, Amy L Rausch, Jeffrey M Snowbarger
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252233 (2021)
Tumor angiogenesis is critical for the growth and progression of cancer. As such, angiostasis is a treatment modality for cancer with potential utility for multiple types of cancer and fewer side effects. However, clinical success of angiostatic mono
Externí odkaz:
https://doaj.org/article/2bcc474f3f2743d2ae3bcf6edb8e2f29
Publikováno v:
The American Biology Teacher. 81:202-209
The central dogma of molecular biology is key to understanding the relationship between genotype and phenotype, although it remains a challenging concept to teach and learn. We describe an activity sequence that engages high school students directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0bb41307eaa71cf5b1c339a55c65c74
https://doi.org/10.1525/abt.2019.81.3.202
https://doi.org/10.1525/abt.2019.81.3.202
Autor:
Michael I. Dorrell
Publikováno v:
The American Biology Teacher. 81:120-125
Evolution is a central principle of biology. However, key aspects of evolution can be very difficult to model in a classroom setting. Two such key principles are (1) how the accumulation of small, relatively minor modifications can lead to the divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9239ee63455076546920e02f2390e03
https://doi.org/10.1525/abt.2019.81.2.120
https://doi.org/10.1525/abt.2019.81.2.120
Autor:
Esther W. Lim, Kevin Eade, Michael I. Dorrell, Rebecca B. Berlow, Rando Allikmets, Sarah Giles, Regis Fallon, Joseph A. Hostyk, Sarah Harkins-Perry, Michelle Baldini, Martina Wallace, Lea Scheppke, Marin L. Gantner, Christian M. Metallo, Martin Friedlander, Carolyn Cai, Evan H. Baugh, David Goldstein, Charles J. Wolock, Takayuki Nagasaki
Publikováno v:
Nat Metab
Macular telangiectasia type 2 (MacTel) is a progressive, late-onset retinal degenerative disease linked to decreased serum levels of serine that elevate circulating levels of a toxic ceramide species, deoxysphingolipids (deoxySLs); however, causal ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af9674620f3aad2e77545c8fc241f3a
https://pubmed.ncbi.nlm.nih.gov/33758422
https://pubmed.ncbi.nlm.nih.gov/33758422
Autor:
Yoshihiko Usui, Michael I. Dorrell, Toshihide Kurihara, Martin Friedlander, Ayumi Usui-Ouchi, Stephen Bravo, Yoichiro Ideguchi, Susumu Sakimoto, Edith Aguilar
Publikováno v:
JCI Insight
Abnormal subretinal neovascularization is a characteristic of vision-threatening retinal diseases, including macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP). Subretinal neovascular tufts and photoreceptor dysfunction are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0056f6c2eb7dd78f40f3a3b73c915b
https://pubmed.ncbi.nlm.nih.gov/32437334
https://pubmed.ncbi.nlm.nih.gov/32437334
Autor:
Michael I. Dorrell, Carli M Wittgrove, Yoshihiko Usui, Maki Kitano, Edith Aguilar, Martin Friedlander, Amelia Schricker, Susumu Sakimoto, Peter D. Westenskow, Salome Murinello, H. Maura Friedlander, Yoshihiro Wakabayashi
Publikováno v:
Glia. 67:332-344
Ischemia-induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti-VEGF agents but are not successful in all cases. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8642f710edc4cee1a1443aa31684aee
https://doi.org/10.1002/glia.23543
https://doi.org/10.1002/glia.23543
Autor:
Tjebo F. C. Heeren, Roberto Bonelli, Maki Kitano, Yoichiro Ideguchi, Regis Fallon, Rando Allikmets, Michael I. Dorrell, Jennifer K Trombley, Lydia Sauer, Mali Okada, Sarah Giles, Robyn H. Guymer, Marin L. Gantner, Barbara Hart, Marcus Fruttiger, Florian Eichler, Kevin Eade, Michal K. Handzlik, Sarah Harkins-Perry, Lea Scheppke, Mehmet G. Badur, Takayuki Nagasaki, Melanie Bahlo, Michelle Baldini, Sasha Woods, Mark C Gillies, Martina Wallace, Carolyn Cai, Paul S. Bernstein, Christian M. Metallo, Martin Friedlander, Catherine A Egan
Publikováno v:
The New England journal of medicine. 381(15)
Identifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia type 2, is challenging. A link between macular telangiectasia type 2 and altered serine metabolism has been established previously.Through exome sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51180c3bfb1667877c55183392dc77a3
https://pubmed.ncbi.nlm.nih.gov/31509668
https://pubmed.ncbi.nlm.nih.gov/31509668
Autor:
Salome, Murinello, Yoshihiko, Usui, Susumu, Sakimoto, Maki, Kitano, Edith, Aguilar, H Maura, Friedlander, Amelia, Schricker, Carli, Wittgrove, Yoshihiro, Wakabayashi, Michael I, Dorrell, Peter D, Westenskow, Martin, Friedlander
Publikováno v:
Glia. 67(2)
Ischemia-induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti-VEGF agents but are not successful in all cases. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3235d51430bbfab5eda9af3efaa62ee8
https://pubmed.ncbi.nlm.nih.gov/30484883
https://pubmed.ncbi.nlm.nih.gov/30484883
Autor:
Felicitas Bucher, Michael I. Dorrell, Lea Scheppke, Edith Aguilar, Peter D. Westenskow, Martin Friedlander, Liliana P Paris, Salome Murinello, Susumu Sakimoto, Yoshihiko Usui
Publikováno v:
Annual review of vision science. 1
The retina consists of organized layers of photoreceptors, interneurons, glia, epithelial cells, and endothelial cells. The economic model of supply and demand used to appropriately determine cost is highly applicable to the retina, in which the extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d2165ed427664f5981392f74a3d205
https://pubmed.ncbi.nlm.nih.gov/28532369
https://pubmed.ncbi.nlm.nih.gov/28532369