Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael I Bukrinsky"'
Publikováno v:
Vaccines, Vol 8, Iss 3, p 421 (2020)
The term “Exosomes” defines small extracellular vesicles, ranging from 30 to 150 nm in diameter, secreted by most eukaryotic cells into surrounding body fluids including blood, saliva, urine, bile and breast milk [...]
Externí odkaz:
https://doaj.org/article/421fc9be1f714c69b033fbcb833e8fd9
Autor:
Sutas Suttiprapa, Gabriel Rinaldi, Isheng J Tsai, Victoria H Mann, Larisa Dubrovsky, Hong-Bin Yan, Nancy Holroyd, Thomas Huckvale, Caroline Durrant, Anna V Protasio, Tatiana Pushkarsky, Sergey Iordanskiy, Matthew Berriman, Michael I Bukrinsky, Paul J Brindley
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005931 (2016)
Schistosomiasis is the most important helminthic disease of humanity in terms of morbidity and mortality. Facile manipulation of schistosomes using lentiviruses would enable advances in functional genomics in these and related neglected tropical dise
Externí odkaz:
https://doaj.org/article/1f00e14133d744a8928a8c41a4c3c2a2
Autor:
Jessica K. Schenck, Molly T. Karl, Cheryl Clarkson-Paredes, Ashley Bastin, Tatiana Pushkarsky, Beda Brichacek, Robert H. Miller, Michael I. Bukrinsky
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract HIV-associated neurocognitive disorders (HAND) are a spectrum of cognitive impairments that continue to affect approximately half of all HIV-positive individuals despite effective viral suppression through antiretroviral therapy (ART). White
Externí odkaz:
https://doaj.org/article/a29aa98ca3b74c7cb0b605d575593cfb
Publikováno v:
Viruses, Vol 16, Iss 5, p 784 (2024)
Epidemiologic studies have established that mpox (formerly known as monkeypox) outbreaks worldwide in 2022–2023, due to Clade IIb mpox virus (MPXV), disproportionately affected gay, bisexual, and other men who have sex with men. More than 35% and 4
Externí odkaz:
https://doaj.org/article/d9a777005ceb414db04fe88fabf91a48
Autor:
Alexei A. Adzhubei, Amol Kulkarni, Anna P. Tolstova, Anastasia A. Anashkina, Dmitri Sviridov, Alexander A. Makarov, Michael I. Bukrinsky
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3876-3884 (2021)
HIV-1 infection impairs cellular cholesterol efflux by downmodulating the cholesterol transporter ABCA1, leading to metabolic co-morbidities like cardio-vascular disease. The main mechanism of this effect is impairment by the HIV-1 protein Nef of the
Externí odkaz:
https://doaj.org/article/def5ff86429a43d9ae3f541d0c1c16c4
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 5, Pp 601-610 (2020)
Lipid rafts, solid regions of the plasma membrane enriched in cholesterol and glycosphingolipids, are essential parts of a cell. Functionally, lipid rafts present a platform that facilitates interaction of cells with the outside world. However, the u
Externí odkaz:
https://doaj.org/article/de55acac9bed4b19a6929c50372319a0
Autor:
Larisa Dubrovsky, Beda Brichacek, N.M. Prashant, Tatiana Pushkarsky, Nigora Mukhamedova, Dragana Dragoljevic, Michael Fitzgerald, Anelia Horvath, Andrew J. Murphy, Dmitri Sviridov, Michael I Bukrinsky
SummaryPersistent inflammation is a hallmark of HIV infection and is not reversed after suppression of viral replication by anti-retroviral therapy (ART). One explanation for chronic inflammation in ART-treated HIV-infected individuals is hyperreacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b62716c931ef05c6ecfc1ae0e2e596
https://doi.org/10.1101/2022.06.24.497538
https://doi.org/10.1101/2022.06.24.497538
Autor:
Larisa Dubrovsky, Beda Brichacek, N.M. Prashant, Tatiana Pushkarsky, Nigora Mukhamedova, Andrew J. Fleetwood, Yangsong Xu, Dragana Dragoljevic, Michael Fitzgerald, Anelia Horvath, Andrew J. Murphy, Dmitri Sviridov, Michael I. Bukrinsky
Publikováno v:
Cell Reports. 41:111674
A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a phenomenon called "trained immunity." Here, we demonstrate that human monocyte-derived macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0cd7070027eaf4b10ff282f59ab651
https://doi.org/10.1016/j.celrep.2022.111674
https://doi.org/10.1016/j.celrep.2022.111674
Publikováno v:
mBio, Vol 5, Iss 3 (2014)
ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individ
Externí odkaz:
https://doaj.org/article/8034bd37e091475db8918b2804eddb9a
Autor:
Michael I Bukrinsky
Publikováno v:
Frontiers in Bioscience. 4:d772-781
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b9c32d82d1fb9dad9b7f4f4c9a364d5
https://doi.org/10.2741/a393
https://doi.org/10.2741/a393