Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael I Barton"'
Autor:
Stuart A MacGowan, Michael I Barton, Mikhail Kutuzov, Omer Dushek, P Anton van der Merwe, Geoffrey J Barton
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009922 (2022)
SARS-CoV-2 Spike (Spike) binds to human angiotensin-converting enzyme 2 (ACE2) and the strength of this interaction could influence parameters relating to virulence. To explore whether population variants in ACE2 influence Spike binding and hence inf
Externí odkaz:
https://doaj.org/article/dd7dfc2e89aa4c76b68bb960691ddf21
Autor:
Michael I Barton, Stuart A MacGowan, Mikhail A Kutuzov, Omer Dushek, Geoffrey John Barton, P Anton van der Merwe
Publikováno v:
eLife, Vol 10 (2021)
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD are present in SARS-CoV-2 variants of concern that have emerged
Externí odkaz:
https://doaj.org/article/6de5dd278c3443c5b73c853e319f1f0e
Autor:
Eleanor M Denham, Michael I Barton, Susannah M Black, Marcus J Bridge, Ben de Wet, Rachel L Paterson, P Anton van der Merwe, Jesse Goyette
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000549 (2019)
Dose-response experiments are a mainstay of receptor biology studies and can reveal valuable insights into receptor function. Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating the surface
Externí odkaz:
https://doaj.org/article/d01654a54b90421eae3ac160b60d9269
Autor:
Michael I. Barton, Rachel L. Paterson, Eleanor M. Denham, Jesse Goyette, Philip Anton van der Merwe
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Leukocytes interact with other cells using cell surface receptors. The largest group of such receptors are non-catalytic tyrosine phosphorylated receptors (NTRs), also called immunoreceptors. NTR signalling requires phosphorylation of cytopl
Externí odkaz:
https://doaj.org/article/02ad8dfdca4e4ebbb2990557a28fc1c0
Autor:
Stuart A. MacGowan, Michael I. Barton, Mikhail Kutuzov, Omer Dushek, P. Anton van der Merwe, Geoffrey J. Barton
Publikováno v:
PLoS computational biology. 18(3)
SARS-CoV-2 Spike (Spike) binds to human angiotensin-converting enzyme 2 (ACE2) and the strength of this interaction could influence parameters relating to virulence. To explore whether population variants in ACE2 influence Spike binding and hence inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e29d7e5880f81be6b48d4bac437629
https://pubmed.ncbi.nlm.nih.gov/35235558
https://pubmed.ncbi.nlm.nih.gov/35235558
Autor:
Mikhail A Kutuzov, Geoffrey J. Barton, P. Anton van der Merwe, Stuart A. MacGowan, Omer Dushek, Michael I Barton
SARS-CoV-2 infection begins with the interaction of the SARS-CoV-2 Spike (Spike) and human angiotensin-converting enzyme 2 (ACE2). To explore whether population variants in ACE2 might influence Spike binding and hence infection, we selected 10 ACE2 v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6246a291efd50f0ab527ec2a393660
https://doi.org/10.1101/2021.05.21.445118
https://doi.org/10.1101/2021.05.21.445118
Autor:
Omer Dushek, Michael I Barton, Stuart A. MacGowan, Geoffrey J. Barton, Mikhail A Kutuzov, P. Anton van der Merwe
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in the RBD domain are present in SARS-CoV-2 variants of concern that have e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8857533b19f2c41d78856bcafe13b82e
https://doi.org/10.1101/2021.05.18.444646
https://doi.org/10.1101/2021.05.18.444646