Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Michael I, Walton"'
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Autor:
Michelle D. Garrett, Ian Collins, John C. Reader, David H. Williams, Florence I. Raynaud, Suzanne A. Eccles, G. Wynne Aherne, Kathy J. Boxall, Gary Box, Alexis De Haven Brandon, Melanie Valenti, Angela Hayes, Paul D. Eve, Michael I. Walton
PDF file, 63KB, Kinase inhibitory profile of SAR-020106 at 10 μMa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32afb33095afaa0235fcca7f9841e0bf
https://doi.org/10.1158/1535-7163.22485369
https://doi.org/10.1158/1535-7163.22485369
Autor:
Michelle D. Garrett, Ian Collins, John C. Reader, David H. Williams, Florence I. Raynaud, Suzanne A. Eccles, G. Wynne Aherne, Kathy J. Boxall, Gary Box, Alexis De Haven Brandon, Melanie Valenti, Angela Hayes, Paul D. Eve, Michael I. Walton
Genotoxic antitumor agents continue to be the mainstay of current cancer chemotherapy. These drugs cause DNA damage and activate numerous cell cycle checkpoints facilitating DNA repair and the maintenance of genomic integrity. Most human tumors lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a843bca3859feddd43f508c891e9104
https://doi.org/10.1158/1535-7163.c.6531909
https://doi.org/10.1158/1535-7163.c.6531909
Autor:
Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers
Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dcea0f52b51238a6de6ffd30f91afbf
https://doi.org/10.1158/0008-5472.c.6511765.v1
https://doi.org/10.1158/0008-5472.c.6511765.v1
Autor:
Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers
Supplementary Figures - SF1: GI50 determinations for CHK1 inhibitor SRA737 in A549 and SW620 cells. SF2: Knockdown of POLA1, POLE or POLE2 sensitises A549 and SW620 cells to the CHK1 inhibitor MK-8776. SF3: Knockdown of CHK1 sensitises A549 cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d79c50e198ed327844b70f5cfb38389
https://doi.org/10.1158/0008-5472.22424413.v1
https://doi.org/10.1158/0008-5472.22424413.v1
Autor:
Paul Workman, Michelle D. Garrett, Paul A. Clarke, Ian Collins, Daniel L. Cherry, Michael I. Walton, Rebecca F. Rogers
Supplementary Tables - ST1: Significant siRNA hits identified from the large-scale synthetic lethal siRNA screen combined with SRA737 in A549 cells. ST2: Significant siRNA hits identified from the large-scale synthetic lethal siRNA screen combined wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a04c1b488ade94296676f4e30acfbc1
https://doi.org/10.1158/0008-5472.22424410.v1
https://doi.org/10.1158/0008-5472.22424410.v1
Autor:
Michelle D. Garrett, Ian Collins, Antony W. Oliver, Laurence H. Pearl, Wynne Aherne, John J. Caldwell, Laurent Antoni, Katherine J. Boxall, Paul D. Eve, Michael I. Walton, Victoria E. Anderson
Supplementary Tables 1-3 from CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f566c44bebb68ef09bf329ee36115f3
https://doi.org/10.1158/0008-5472.22386057
https://doi.org/10.1158/0008-5472.22386057
Autor:
Michelle D. Garrett, Ian Collins, Antony W. Oliver, Laurence H. Pearl, Wynne Aherne, John J. Caldwell, Laurent Antoni, Katherine J. Boxall, Paul D. Eve, Michael I. Walton, Victoria E. Anderson
Supplementary Figures 1-4 from CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8fc51a578f1ecc82bfac2fce125efd
https://doi.org/10.1158/0008-5472.22386063.v1
https://doi.org/10.1158/0008-5472.22386063.v1
Autor:
Michelle D. Garrett, Ian Collins, Antony W. Oliver, Laurence H. Pearl, Wynne Aherne, John J. Caldwell, Laurent Antoni, Katherine J. Boxall, Paul D. Eve, Michael I. Walton, Victoria E. Anderson
Supplementary Materials from CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3e0b2b93aa040fd4125f4f2fba8d9e
https://doi.org/10.1158/0008-5472.22386060
https://doi.org/10.1158/0008-5472.22386060
Autor:
Paul Workman, Ian Collins, Rebecca Rogers, Daniel L. Cherry, Michelle D. Garrett, Paul A. Clarke, Michael I. Walton
Publikováno v:
Cancer Res
Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01742821eafbec244354ea0af46d7959