Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Michael Humora"'
1
Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068
Autor: Chaomin Li, Yiqing Lin, John Guzowski, Lloyd Franklin, Brian T. Hopkins, Michael MacPhee, Daniel Patience, Bin Ma, Zheng Fengmei, Michael Humora, Robbie Chen, Erin M. O’Brien, George A. Moniz, William F. Kiesman, Steven Ferguson, Tamera Mack
Publikováno v: Organic Process Research & Development. 24:1199-1206
Chemical process development efforts leading to multikilogram production of BIIB068 hemiadipate are discussed. Process optimization resulted in (1) removal of transition metal from the process, (2)...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7697bd2139a22f282f464a8ae16c611
https://doi.org/10.1021/acs.oprd.0c00087
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2
Understanding and Control of Dimethyl Sulfate in a Manufacturing Process: Kinetic Modeling of a Fischer Esterification Catalyzed by H2SO4
Autor: William F. Kiesman, John Guzowski, Michael Humora, Albert Kwok, Edward J. Delaney, Erwin Irdam, Amy D. Moran
Publikováno v: Organic Process Research & Development. 16:232-239
The formation and fate of monomethyl sulfate (MMS) and dimethyl sulfate (DMS) were studied by proton NMR for a sulfuric acid catalyzed esterification reaction in methanol. The kinetic rate constants for DMS and MMS were determined at 65 °C by fittin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdff3b6d30675c2b48aa5c6bce465cf4
https://doi.org/10.1021/op200323j
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3
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator
Autor: Tina Talreja, Arthur G. Taveras, Michael Humora, Lawrence Gan, J. Hernan Cuervo, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Anthone W. Dunah, Gnanasambandam Kumaravel, Pamela A. Snodgrass-Belt, Mi-young Jung, Zhili Xin, Sowmya Chollate, Melanie N. Shackett, Ellen Rohde, H. Moore Arnold, Robert H. Scannevin
Publikováno v: ACS Medicinal Chemistry Letters. 2:786-791
We have investigated a novel series of acid-derived γ-secretase modulators as a potential treatment of Alzheimer's disease. Optimization based on cellular potency and brain pharmacodynamics after oral dosing led to the discovery of 10a (BIIB042). Co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f8cd4a82fc2be0e7dceb3dc620003c
https://doi.org/10.1021/ml200175q
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4
ChemInform Abstract: Acceleration of Petasis Reactions of Salicylaldehyde Derivatives with Molecular Sieves
Autor: Dominique Hebrault, Hairuo Peng, Xianglin Shi, Michael Humora, Zhili Xin, William F. Kiesman, Tina Talreja, Zezhou Wang
Publikováno v: ChemInform. 43
Mild reaction conditions for Petasis reactions of substituted salicylaldehydes with various amines and arylboronic acids in the presence of molecular sieves were developed. Molecular sieves (MS) significantly accelerated the reaction rates and drove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b6874b1e554c5c89346f140472ed5b8
https://doi.org/10.1002/chin.201219074
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5
Acceleration of Petasis reactions of salicylaldehyde derivatives with molecular sieves
Autor: William F. Kiesman, Tina Talreja, Michael Humora, Hairuo Peng, Xianglin Shi, Dominique Hebrault, Zhili Xin, Zezhou Wang
Publikováno v: The Journal of organic chemistry. 77(2)
Mild reaction conditions for Petasis reactions of substituted salicylaldehydes with various amines and arylboronic acids in the presence of molecular sieves were developed. Molecular sieves (MS) significantly accelerated the reaction rates and drove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262cebb3b9063518549acb7ad0a4d001
https://pubmed.ncbi.nlm.nih.gov/22171661
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