Výsledky vyhledávání - "Michael Humbert"

Akademický článek

Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions.

Autor: Liesbeth Van Nieuwenhove, Philippe Büscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1682 (2012)

BACKGROUND: At present, screening of the population at risk for gambiense human African trypanosomiasis (HAT) is based on detection of antibodies against native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. Drawbacks of

Externí odkaz: https://doaj.org/article/9f32787d3284478c955496a9739a74db

Zobrazit plný text záznamu

Akademický článek

Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

Autor: Anton M Sholukh, Muhammad M Mukhtar, Michael Humbert, Sosthène S Essono, Jennifer D Watkins, Hemant K Vyas, Vivekanandan Shanmuganathan, Girish Hemashettar, Maria Kahn, Shiu-Lok Hu, David C Montefiori, Victoria R Polonis, Peter H Schur, Ruth M Ruprecht

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38943 (2012)

Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics (mimotopes) that reflect the

Externí odkaz: https://doaj.org/article/a1ec615739fa408abdc9fe5924127437

Zobrazit plný text záznamu

Akademický článek

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18207 (2011)

Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in viv

Externí odkaz: https://doaj.org/article/18a1fa172f0a46cfb860a5bf3ee5b5cf

Zobrazit plný text záznamu

Akademický článek

Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing.

Autor: Michael Humbert, Robert A Rasmussen, Helena Ong, Fabian M P Kaiser, Shiu-Lok Hu, Ruth M Ruprecht

Publikováno v: PLoS ONE, Vol 3, Iss 12, p e3937 (2008)

Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics m

Externí odkaz: https://doaj.org/article/64b889ddfcf948f2bbba16b20a7db961

Zobrazit plný text záznamu

Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants

Autor: Gregor Maurer, Anthony Griffiths, Joshua Owuor, Michael Humbert, David C. Montefiori, Hemant K. Vyas, Swati Thorat, Francois Villinger, Sanjeev Gumber, Hanna B. Scinto, Ruth M. Ruprecht, Siddappa N. Byrareddy, Muhammad Mukhtar, Yi Chen, Zhao Lai, Agnès Laurence Chenine, Mingkui Zhou, Samir K. Lakhashe

Publikováno v: Journal of Virology. 93

Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. HIV-1 clade A (HIV-A) predominates in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfc1705ee1311067009be8d2cf4e0c4
https://doi.org/10.1128/jvi.02267-18

Zobrazit plný text záznamu

Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection

Autor: Samir K. Lakhashe, Robert A. Rasmussen, Nagadenahalli B. Siddappa, Michael Humbert, Barbara C. Bachler, Brisa Palikuqi, Ruth M. Ruprecht

Publikováno v: Journal of Virology. 87:4403-4416

Identifying immune correlates of protection is important to develop vaccines against infectious diseases. We designed a novel, universally applicable strategy to profile the antibody (Ab) repertoire of protected vaccine recipients, using recombinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be30204b82794f811fcbf8cb837b6a2e
https://doi.org/10.1128/jvi.02888-12

Zobrazit plný text záznamu

Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication

Autor: Michael Humbert, Rik Gijsbers, Belete Ayele Desimmie, Zeger Debyser, Eveline Lescrinier, Ursula Dietrich, Sofie Vets, Ruth M. Ruprecht, Jelle Hendrix, Frauke Christ

Publikováno v: Molecular Therapy; Vol 20
Mol Ther

The interaction between the human immunodeficiency virus (HIV) integrase (IN) and its cellular cofactor lens epithelium-derived growth factor (LEDGF/p75) is crucial for HIV replication. While recently discovered LEDGINs inhibit HIV-1 replication by o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084057acbde7d17342bd61cf906a2825

Zobrazit plný text záznamu

Unravelling the antigenic landscape of the HIV-1 subtype A envelope of an individual with broad cross-neutralizing antibodies using phage display peptide libraries

Autor: Ursula Dietrich, Wouter Janssens, Tessa Dieltjens, Guido Vanham, Sandra Coppens, Leo Heyndrickx, Lies L. Van Nieuwenhove, Michael Humbert, B. Willems

Publikováno v: Journal of Virological Methods; Vol 169
Journal of Virological Methods
Journal of virological methods

Broad cross-neutralizing antibodies from persons infected with HIV-1 target a variety of epitopes. Identification of these HIV-1 epitopes may result in an optimal panel of antigenic peptides to be included in a prophylactic vaccine. Phage display pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76deeb51b7b89f93f428f2f358e02d5d

Zobrazit plný text záznamu

Genetic and Biological Characterization of Recombinant HIV Type 1 with Env Derived from Long-Term Nonprogressor (LTNP) Viruses

Autor: Margot Landersz, Christian Seidl, Michael Humbert, Sascha Antoni, Matthias T. Dittmar, Nicole Walz, Ursula Dietrich

Publikováno v: AIDS Research and Human Retroviruses. 23:1377-1386

Multiple factors are known to contribute to nonprogressive disease in long-term nonprogressors (LTNP). We previously selected LTNPs, in which broadly neutralizing antibodies against HIV-1 very likely contribute to disease prevention. Here, we charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66474d0d9340c853aa5cd09e27af1515
https://doi.org/10.1089/aid.2007.0113

Zobrazit plný text záznamu

A peptide inhibitor of HIV-1 assembly in vitro

Autor: Hans-Georg Kräusslich, Jörn M. Werner, Michael Humbert, Stuart C. Findlow, Barbara Müller, Ursula Dietrich, Jana Sticht, Jochen Bodem

Publikováno v: Nature Structural & Molecular Biology. 12:671-677

Formation of infectious HIV-1 involves assembly of Gag polyproteins into immature particles and subsequent assembly of mature capsids after proteolytic disassembly of the Gag shell. We report a 12-mer peptide, capsid assembly inhibitor (CAI), that bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6a99467bb2e4b8f7c687a91721ae0e
https://doi.org/10.1038/nsmb964

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání