Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael Hinchcliffe"'
Autor:
Veronica Martini, Michael Hinchcliffe, Elaine Blackshaw, Mary Joyce, Adam McNee, Peter Beverley, Alain Townsend, Ronan MacLoughlin, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent evidence indicates that local immune responses and tissue resident memory T cells (TRM) are critical for protection against respiratory infections but there is little information on the contributions of upper and lower respiratory tract (URT a
Externí odkaz:
https://doaj.org/article/2fd22e5e833949c6b9a2e7ef125313ec
Autor:
Richard G. Pearson, Tahir Masud, Elaine Blackshaw, Andrew Naylor, Michael Hinchcliffe, Kirk Jeffery, Faron Jordan, Anjumn Shabir-Ahmed, Gareth King, Andrew L. Lewis, Lisbeth Illum, Alan C. Perkins
Publikováno v:
Pharmaceutics, Vol 11, Iss 6, p 265 (2019)
Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati
Externí odkaz:
https://doaj.org/article/835f2d5b3a3e42739c1270f537c2dac0
Autor:
Alex J Mann, Nicolas Noulin, Andrew Catchpole, Koert J Stittelaar, Leon de Waal, Edwin J B Veldhuis Kroeze, Michael Hinchcliffe, Alan Smith, Emanuele Montomoli, Simona Piccirella, Albert D M E Osterhaus, Alastair Knight, John S Oxford, Giulia Lapini, Rebecca Cox, Rob Lambkin-Williams
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e93761 (2014)
We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets
Externí odkaz:
https://doaj.org/article/36bbfb15eb674f50b47050f2bd12c9a0
Autor:
Elma Tchilian, Peter Beverley, Alain Townsend, Mary Joyce, Michael Hinchcliffe, Adam McNee, Ronan MacLoughlin, Elaine Blackshaw, Veronica Martini
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Recent evidence indicates that local immune responses and tissue resident memory T cells (TRM) are critical for protection against respiratory infections but there is little information on the contributions of upper and lower respiratory tract (URT a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228758365145f41edc74c5869da2f3d8
https://doi.org/10.1101/2020.06.04.134098
https://doi.org/10.1101/2020.06.04.134098
Autor:
Andrew Naylor, Tahir Masud, R.G. Pearson, Elaine Blackshaw, Andrew L. Lewis, Anjumn Shabir-Ahmed, Gareth King, Lisbeth Illum, Michael Hinchcliffe, Faron Jordan, Kirk Jeffery, Alan C. Perkins
Publikováno v:
Pharmaceutics, Vol 11, Iss 6, p 265 (2019)
Pharmaceutics
Volume 11
Issue 6
Pharmaceutics
Volume 11
Issue 6
Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati
Autor:
Alan Smith, Michael Hinchcliffe
Publikováno v:
Degenerative Neurological and Neuromuscular Disease
Amyotrophic lateral sclerosis (ALS) is the commonest form of motor neuron disease and is a fatal, degenerative, multisystem disorder affecting upper and/or lower motor neurons in the motor cortex, brain stem, and spinal cord. ALS is characterized by
Autor:
Simona Piccirella, Åsne Jul-Larsen, Jane Kristin Nøstbakken, Geir Bredholt, Carlos Guzmán, Inderjit Jabbal-Gill, Giulia Lapini, Michael Hinchcliffe, Emanuele Montomoli, Gabriel K. Pedersen, Rebecca Jane Cox, Signe Svindland, Rishi D. Pathirana
Publikováno v:
Influenza and Other Respiratory Viruses. 7:1181-1193
Please cite this paper as: Svindland et al. (2012) A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine. Influenza and Other Respiratory Viruses 10.1111/irv.12056000(000), 000–000. Background Highly pathogenic
Autor:
Alan M. Smith, Inderjit Jabbal-Gill, Richard Nankervis, A. Margaret Dyer, Yu-Hui Cheng, Michael Hinchcliffe, Peter Watts
Publikováno v:
European Journal of Pharmaceutical Sciences. 26:9-15
The effectiveness of chitosan in promoting the intranasal bioavailability of recombinant human growth hormone (hGH) has been evaluated. hGH was formulated with chitosan to produce a powder blend (Formulation A) and granules (Formulation B) for intran
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:681-687
The effects of a chitosan-based delivery system on the pharmacokinetics of intranasally administered salmon calcitonin (sCT) were investigated in a sheep model. In particular, the feasibility of producing a formulation with a comparable or improved b
Autor:
Abraham Rami, Tzafriri, Elyakum Itzhak, Lerner, Moshe, Flashner-Barak, Michael, Hinchcliffe, Eli, Ratner, Hanna, Parnas
Publikováno v:
Clinical Cancer Research. 11:826-834
Purpose: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at differen